DrugAge entry for Eserine

Name: Eserine
Synonyms: (-)-physostigmine • (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate • 57-47-6 • 57-47-6 (free base) • 9U1VM840SP • Antilirium • Calabarine • CHEBI:27953 • CHEMBL94 • DSSTox_CID_3471 • DSSTox_GSID_23471 • DSSTox_RID_77040 • Erserine • Eserine • Eserine sulfate • Eserolein, methylcarbamate (ester) • Esromiotin • Ezerin • Fysostigmin • NCGC00093889-03 • NSC-30782 • NSC30782 • physostigmine • Physostol • UNII-9U1VM840SP • [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
CAS Number: 57-47-6
IUPAC Name: [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
PubChem CID: 5983

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Eserine

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Eserine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Eserine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id