DrugAge entry for Epicatechin

Name: Epicatechin
Synonyms: (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol • (-)-Epicatechin • (-)-Epicatechol • (-)epicatechin • (2R,3R)-(-)-Epicatechin • (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol • (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol • 2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromene • 490-46-0 • AK105372 • C15H14O6 • CCRIS 7097 • CHEBI:90 • EINECS 207-710-1 • epi-Catechin • epi-Catechol • Epicatechin • Epicatechol • Epicatechol, (-)- • l-Acacatechin • L-Epicatechin • l-Epicatechol • NSC 81161 • PFTAWBLQPZVEMU-UKRRQHHQSA-N • UNII-34PHS7TU43
CAS Number: 490-46-0
IUPAC Name: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
PubChem CID: 72276
SEP-L1000 side effects: Anaemia, Asthenia, Body temperature increased, Chest pain, Convulsion, Diarrhoea, Dizziness, Dyspepsia, Erythema, Headache, Infection, Nausea, Oedema, Pain, Pruritus, Rash, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Epicatechin

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Massie, HR et al. (1993) Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67(3)227-237 PubMed
Bartholome, A et al. (2010) Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch. Biochem. Biophys. 501(1)58-64 PubMed
Si, H et al. (2011) Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J. Nutr. 141(6)1095-1100 PubMed
Proshkina E, et al. (2016) Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster Front Pharmacol () PubMed

DGIdb Human Drug-Gene Interactions for Epicatechin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Epicatechin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id