DrugAge entry for Epicatechin

Name
Epicatechin 
Synonyms
(-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol • (-)-Epicatechin • (-)-Epicatechol • (-)epicatechin • (2R,3R)-(-)-Epicatechin • (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol • (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol • 2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromene • 490-46-0 • AK105372 • C15H14O6 • CCRIS 7097 • CHEBI:90 • EINECS 207-710-1 • epi-Catechin • epi-Catechol • Epicatechin • Epicatechol • Epicatechol, (-)- • l-Acacatechin • L-Epicatechin • l-Epicatechol • NSC 81161 • PFTAWBLQPZVEMU-UKRRQHHQSA-N • UNII-34PHS7TU43 
CAS Number
490-46-0 
IUPAC Name
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol 
PubChem CID
72276 
SEP-L1000 side effects
Anaemia, Asthenia, Body temperature increased, Chest pain, Convulsion, Diarrhoea, Dizziness, Dyspepsia, Erythema, Headache, Infection, Nausea, Oedema, Pain, Pruritus, Rash, Urticaria, Vomiting 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Epicatechin


References

Massie, HR et al. (1993) Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67(3)227-237 PubMed
Bartholome, A et al. (2010) Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch. Biochem. Biophys. 501(1)58-64 PubMed
Si, H et al. (2011) Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J. Nutr. 141(6)1095-1100 PubMed
Proshkina E, et al. (2016) Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster Front Pharmacol () PubMed

DGIdb Human Drug-Gene Interactions for Epicatechin

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Epicatechin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id