DrugAge entry for Ellagic acid

Name: Ellagic acid
Synonyms: 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione • 476-66-4 • Acide ellagique • Acide ellagique [INN-French] • Acido elagico • Acido elagico [INN-Spanish] • Acidum ellagicum • Acidum ellagicum [INN-Latin] • Alizarine Yellow • Benzoaric acid • C.I. 55005 • C.I. 75270 • CCRIS 774 • Elagostasine • Eleagic acid • Ellagate • ellagic acid • Ellagic acid [INN:DCF] • Gallogen (astringent) • Gallogen (VAN) • Gallogen, astringent • Lagistase • Llagic acid • MLS000069632 • UNII-19YRN3ZS9P
CAS Number: 476-66-4
IUPAC Name: 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^4,16.0^11,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione
PubChem CID
SEP-L1000 side effects: Abdominal pain, Asthenia, Body temperature increased, Cough, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Erythema, Fatigue, Headache, Hypersensitivity, Hypertension, Insomnia, Nausea, Oedema, Pain, Pruritus, Rash, Somnolence, Tachycardia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Ellagic acid

Average/Median Lifespan
Max Lifespan
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References

Ryu D, et al. (2016) Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents Nature Medicine () PubMed
Kharat, P et al. (2020) Ellagic acid prolongs the lifespan of Drosophila melanogaster. Geroscience 42(1)271-285 PubMed
Saul, N et al. (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J. Nat. Prod. 74(8)1713-1720 PubMed

DGIdb Human Drug-Gene Interactions for Ellagic acid

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Ellagic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id