DrugAge entry for EUK-8

Name: EUK-8
Synonyms: 53177-12-1 • AC1L575B • AN-40880 • CE-850 • EUK 8 • euk-8 • FT-0686832 • MANGANESE(3+) ION 2-{[(2-{[(2-OXIDOPHENYL)METHYLIDENE]AMINO}ETHYL)IMINO]METHYL}BENZENOLATE CHLORIDE • manganese(3+); 2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate; chloride • Manganese, chloro((2,2'-(1,2-ethanediylbis(nitrilomethylidyne))bis(phenolato))(2-)-N,N',O,O')-, (SP-5-13)- • manganic 2-[2-[(2-oxidophenyl)methyleneamino]ethyliminomethyl]phenolate chloride • N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II) • N,N'-Bis(salicylideneamino)ethane-manganese(II) • OR069843 • Salen-manganese complex
CAS Number: 53177-12-1
IUPAC Name: manganese(3+);2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate;chloride
PubChem CID: 171249

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for EUK-8

Average/Median Lifespan
Max Lifespan
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References

Melov, S et al. (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289(5484)1567-1569 PubMed
Keaney, M and Gems, D (2003) No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radic. Biol. Med. 34(2)277-282 PubMed

DGIdb Human Drug-Gene Interactions for EUK-8

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for EUK-8

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id