DrugAge entry for Doxazosin mesylate

Name: Doxazosin mesylate
Synonyms: (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone methanesulfonate • 77883-43-3 • Alfadil • Benur • C24H29N5O8S • Cardenalin • Cardoral • Cardoxan • Cardular • Cardura • Cardura XL • Carduran • Dedralen • Diblocin • Doksura • Doxaben • Doxazomerck • Doxazosin (mesylate) • Doxazosin AZU • Doxazosin mesilate • Doxazosin mesylate • Doxolbran • Kaltensif • MFCD00216023 • MLS000028455 • Normathen • Progandol • Prostadilat • Supressin • Tensiobas • Tonocardin • UK 33274 mesylate
CAS Number: 77883-43-3
IUPAC Name: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid
PubChem CID: 62978

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Doxazosin mesylate

Average/Median Lifespan
Max Lifespan
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References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Doxazosin mesylate

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Doxazosin mesylate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id