DrugAge entry for Dofetilide

Name: Dofetilide
Synonyms: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane • 115256-11-6 • beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide • C19H27N3O5S2 • CHEBI:4681 • CHEMBL473 • Dofetilida • Dofetilida [INN-Spanish] • Dofetilide • Dofetilide (Tikosyn) • Dofetilidum • Dofetilidum [INN-Latin] • DSSTox_CID_26433 • DSSTox_GSID_46433 • DSSTox_RID_81610 • Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]- • N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide • N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide • N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide • NCGC00164549-01 • R4Z9X1N2ND • Tikosyn • UK 68798 • UK-68,798 • UK-68798 • UNII-R4Z9X1N2ND
CAS Number: 115256-11-6
IUPAC Name: N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
PubChem CID: 71329

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Dofetilide

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Dofetilide

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Dofetilide

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id