DrugAge entry for Diosgenin

Name: Diosgenin
Synonyms: (20R,25R)-Spirost-5-en-3beta-ol • (25R)-5-Spirosten-3beta-ol • (25R)-spirost-5-en-3beta-diol • (25R)-Spirost-5-en-3beta-ol • (3beta,25R)-spirost-5-en-3-ol • (7S,8S,10S,13S,15S,18S,22S,3R,12R,14R,19R)-3,13,15,19-tetramethyl-11-oxaspiro[ 2H-3,4,5,6-tetrahydropyran-6,6'-pentacyclo[10.8.0.0<2,9>.0<4,8>.0<13,18>]icosa ne]-24-en-22-ol • 22alpha-Spirost-5-en-3beta-ol • 3beta-Hydroxy-5-spirostene • 512-04-9 • BRN 0094582 • CCRIS 6803 • CHEBI:4629 • DIOSGENIN • Diosgenin,(S) • EINECS 208-134-3 • K49P2K8WLX • Nitogenin • nitrogen in • NSC 33396 • SP 37 • Spirost-5-en-3-beta-ol, (25R)- • Spirost-5-en-3-ol, (3-beta,25R)- • Spirost-5-en-3-ol, (3b,25R)- • Spirost-5-en-3-ol,(3b,25R)- • UNII-K49P2K8WLX
CAS Number: 512-04-9
IUPAC Name
PubChem CID

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Diosgenin

Average/Median Lifespan
Max Lifespan
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References

Shanmugam G, et al. (2017) Diosgenin a phytosterol substitute for cholesterol, prolongs the lifespan and mitigates glucose toxicity via DAF-16/FOXO and GST-4 in Caenorhabditis elegans Biomedicine and pharmacotherapy () PubMed

DGIdb Human Drug-Gene Interactions for Diosgenin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Diosgenin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id