DrugAge entry for Dihydroxyflavone

Name: Dihydroxyflavone
Synonyms: 3,5,-Dihydroxyflavone • 3,5-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one • 3,5-dihydroxy-2-phenyl-4H-chromen-4-one • 3,5-dihydroxy-2-phenyl-chromen-4-one • 3,5-dihydroxy-2-phenylchromen-4-one • 3,5-DIHYDROXYFLAVONE • 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-phenyl- • 6665-69-6 • AKOS024285110 • BDBM50222291 • CHEMBL239276 • DTXSID30419823 • MCULE-5859398695 • MFCD00143074 • NCGC00096043-01 • SCHEMBL290081 • SPECTRUM1505147 • SR-05000002503 • ST081626 • ZINC57647
CAS Number: 6665-69-6
IUPAC Name: 3,5-dihydroxy-2-phenylchromen-4-one
PubChem CID: 5393151

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Dihydroxyflavone

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Dihydroxyflavone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Dihydroxyflavone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id