DrugAge entry for DTT

Name: DTT
Synonyms: (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol • (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL • (2S,3S)-1,4-disulfanylbutane-2,3-diol • 03/12/3483 • 1,4-Dithiothreithol • 1,4-Dithiothreitol • 27565-41-9 • 3483-12-3 • CHEBI:42170 • cis-2,3-Dihydroxy-1,4-butanedithiol • Cleland's reagent • D-1,4-Dithiothreitol • D-Dithiothreitol • D-Dtt • D-threo-1,4-Dimercapto-2,3-butanediol • dithio threitol • Dithiothreitol • DL-1,4-Dithiothreitol • DL-1,4-Dithiothreitol, 98%, pure • DL-1,4-Dithiothreitol, 99%, for biochemistry • dl-Dithiothreitol • DTT • DTV • MFCD00004877 • rac-Dithiothreitol • Sputolysin • threo-1,4-Dimercapto-2,3-butanediol
CAS Number: 3483-12-3
IUPAC Name: (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
PubChem CID: 446094

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for DTT

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for DTT

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for DTT

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id