DrugAge entry for D-xylitol

Name: D-xylitol
Synonyms: 1,2,3,4,5-pentanepentol • 488-81-3 • 87-99-0 • Adonit • Adonite • adonitol • D-ribitol • D-Xylitol • Eutrit • Kannit • Klinit • L-ribitol • L-xylitol • meso-ribitol • meso-xylitol • Newtol • ribitol • UNII-353ZQ9TVDA • UNII-VCQ006KQ1E • Xylisorb • Xylit • Xylite • Xylite (sugar) • xylitol • Xyliton
CAS Number: 87-99-0
IUPAC Name: (2S,4R)-pentane-1,2,3,4,5-pentol
PubChem CID: 6912

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for D-xylitol

Average/Median Lifespan
Max Lifespan
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References

Kaeberlein, M et al. (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell. Biol. 22(22)8056-8066 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for D-xylitol

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for D-xylitol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id