DrugAge entry for Cyclosporin A

Name: Cyclosporin A
Synonyms: 59865-13-3 • 83HN0GTJ6D • Antibiotic S 7481F1 • Ciclosporin • Ciclosporina • Ciclosporine • Ciclosporinum • Consupren • Cyclosporin • cyclosporin A • cyclosporine • Cyclosporine A • Equoral • Gengraf • Neoplanta • Neoral • Ramihyphin A • Restasis • Sandimmun • Sandimmun Neoral • Sandimmune • Sang-35 • SangCyA • UNII-83HN0GTJ6D • Vekacia
CAS Number: 59865-13-3
IUPAC Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
PubChem CID: 5284373
SEP-L1000 side effects: Abdominal pain, Alopecia, Anaemia, Anxiety, Arthralgia, Asthenia, Body temperature increased, Chills, Constipation, Cough, Decreased appetite, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Erythema, Haemorrhage, Headache, Hyperhidrosis, Hypersensitivity, Hypotension, Infection, Influenza, Insomnia, Leukopenia, Malaise, Nausea, Neuropathy peripheral, Neutropenia, Oedema, Pain, Pancreatitis, Paraesthesia, Pruritus, Rash, Renal failure, Stomatitis, Thrombocytopenia, Urticaria, Vertigo, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Cyclosporin A

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Diana Brust (2010) Cyclophilin D links programmed cell death and organismal aging in Podospora anserina Aging Cell 9(5)761-75 PubMed

DGIdb Human Drug-Gene Interactions for Cyclosporin A

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Cyclosporin A

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id