DrugAge entry for Cortisone

Name
Cortisone 
Synonyms
11-Dehydro-17-hydroxycorticosterone • 17-Hydroxy-11-dehydrocorticosterone • 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione • 17alpha-Hydroxy-11-dehydrocorticosterone • 4-Pregnene-17alpha,21-diol-3,11,20-trione • 53-06-5 • Adrenalex • Andreson • Cortandren • Cortisal • Cortisate • Cortison • Cortisona • Cortisona [INN-Spanish] • cortisone • Cortisone [INN:BAN] • Cortisonum [INN-Latin] • Cortistal • Cortivite • Cortogen • Cortone • Kendall's compound E • Reichstein Fa • Reichstein's substance FA • Wintersteiner's compound F 
CAS Number
53-06-5 
IUPAC Name
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione 
PubChem CID
222786 
SEP-L1000 side effects
Abdominal distension, Alkalosis, Alkalosis hypokalaemic, Angioedema, Asthenia, Benign intracranial hypertension, Carbohydrate tolerance decreased, Cardiac failure, Cardiac failure congestive, Cataract, Cataract subcapsular, Compression fracture, Convulsion, Cushingoid, Diabetes mellitus, Ecchymosis, Electrolyte imbalance, Embolism, Erythema, Exophthalmos, Fluid retention, Gastrointestinal disorder, Glaucoma, Glucose tolerance impaired, Haemorrhage, Headache, Hirsutism, Hyperhidrosis, Hypernatraemia, Hypertension, Impaired healing, Increased appetite, Infarction, Inflammatory bowel disease, Intracranial pressure increased, Intraocular pressure increased, Malaise, Mass, Menstruation irregular, Muscle mass, Muscular weakness, Myocardial infarction, Myocardial rupture, Myopathy, Nausea, Necrosis, Nitrogen balance negative, Oedema, Oesophagitis, Oesophagitis ulcerative, Osteonecrosis, Osteoporosis, Pancreatitis, Papilloedema, Pathological fracture, Peptic ulcer, Petechiae, Skin test positive, Urticaria, Vertigo, W 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Cortisone


References

Bozovic, V and Enesco, HE (1989) Cortisone extends life span in the rotifer Asplanchna brightwelli. Arch Gerontol Geriatr 9(1)45-51 PubMed

DGIdb Human Drug-Gene Interactions for Cortisone

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Cortisone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id