DrugAge entry for Cortisone

Name: Cortisone
Synonyms: 11-Dehydro-17-hydroxycorticosterone • 17-Hydroxy-11-dehydrocorticosterone • 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione • 17alpha-Hydroxy-11-dehydrocorticosterone • 4-Pregnene-17alpha,21-diol-3,11,20-trione • 53-06-5 • Adrenalex • Andreson • Cortandren • Cortisal • Cortisate • Cortison • Cortisona • Cortisona [INN-Spanish] • cortisone • Cortisone [INN:BAN] • Cortisonum [INN-Latin] • Cortistal • Cortivite • Cortogen • Cortone • Kendall's compound E • Reichstein Fa • Reichstein's substance FA • Wintersteiner's compound F
CAS Number: 53-06-5
IUPAC Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
PubChem CID: 222786
SEP-L1000 side effects: Abdominal distension, Alkalosis, Alkalosis hypokalaemic, Angioedema, Asthenia, Benign intracranial hypertension, Carbohydrate tolerance decreased, Cardiac failure, Cardiac failure congestive, Cataract, Cataract subcapsular, Compression fracture, Convulsion, Cushingoid, Diabetes mellitus, Ecchymosis, Electrolyte imbalance, Embolism, Erythema, Exophthalmos, Fluid retention, Gastrointestinal disorder, Glaucoma, Glucose tolerance impaired, Haemorrhage, Headache, Hirsutism, Hyperhidrosis, Hypernatraemia, Hypertension, Impaired healing, Increased appetite, Infarction, Inflammatory bowel disease, Intracranial pressure increased, Intraocular pressure increased, Malaise, Mass, Menstruation irregular, Muscle mass, Muscular weakness, Myocardial infarction, Myocardial rupture, Myopathy, Nausea, Necrosis, Nitrogen balance negative, Oedema, Oesophagitis, Oesophagitis ulcerative, Osteonecrosis, Osteoporosis, Pancreatitis, Papilloedema, Pathological fracture, Peptic ulcer, Petechiae, Skin test positive, Urticaria, Vertigo, W

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Cortisone

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Bozovic, V and Enesco, HE (1989) Cortisone extends life span in the rotifer Asplanchna brightwelli. Arch Gerontol Geriatr 9(1)45-51 PubMed

DGIdb Human Drug-Gene Interactions for Cortisone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Cortisone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id