DrugAge entry for Chloroquine
- Name
- Chloroquine
- Synonyms
- 54-05-7 • Aralen • Arthrochin • Artrichin • Bemasulph • Benaquin • Bipiquin • Capquin • Chemochin • Chingamin • Chloraquine • Chlorochin • Chloroquina • chloroquine • Chloroquinium • Chlorquin • Cidanchin • Clorochina • Cocartrit • Dichinalex • Gontochin • Heliopar • Iroquine • Malaquin • Reumachlor
- CAS Number
- 54-05-7
- IUPAC Name
- 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
- PubChem CID
- 2719
- SEP-L1000 side effects
- Abdominal pain, Agitation, Agranulocytosis, Alopecia, Anaemia, Anaphylactoid reaction, Angioedema, Anxiety, Aplastic anaemia, Asthenia, Atrophy, Cardiomyopathy, Confusional state, Convulsion, Corneal opacity, Deafness, Decreased appetite, Delirium, Dermatitis, Dermatitis exfoliative, Diarrhoea, Electrocardiogram change, Erythema, Erythema multiforme, Gastrointestinal disorder, Hallucination, Headache, Hepatic enzyme increased, Hepatitis, Hypotension, Insomnia, Muscle spasms, Myopathy, Nausea, Neutropenia, Personality change, Photosensitivity reaction, Polyneuropathy, Pruritus, Psychotic disorder, Rash, Rash papular, Scotoma, Skin exfoliation, Thrombocytopenia, Tinnitus, Toxic epidermal necrolysis, Urticaria, Vision blurred, Visual impairment, Vomiting
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Chloroquine
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Hochschild, R. (1971) Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster. Exp Gerontol 6(2)133-151 PubMedLi, W et al. (2022) Low-dose chloroquine treatment extends the lifespan of aged rats. Protein & cell 13(6)454-461 PubMed
Hochschild R. (1973) Effects of various drugs on longevity in female C57BL-6J mice Gerontologia () PubMed
Doeppner, TR et al. (2022) Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism. Aging 14(10)4195-4210 PubMed
DGIdb Human Drug-Gene Interactions for Chloroquine
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Chloroquine
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|