DrugAge entry for Chicoric acid

Name: Chicoric acid
Synonyms: (-)-Chicoric acid • (-)-L-Chicoric acid • (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid • (R-(R*,R*-(E,E)))-2,3-Bis((3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)butanedioic acid • 1-chicoricacid • 2,3-Bis((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)butanedioic acid • 6537-80-0 • 70831-56-0 • Butanedioic acid, 2,3-bis(((2E)-3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)-, (2R,3R)- • Butanedioic acid, 2,3-bis((3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)-, (R-(R*,R*-(E,E)))- • Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-, (2R,3R)- • CHEBI:3594 • CHEMBL282731 • Chicoric acid • Cichoric Acid • Cichoric-Acid • Dicaffeoyl-L-tartaric acid • L-Chicoric acid • l-Chicoric-acid • L-Cichoric acid • L-DCTA • NSC 699173 • NSC699173 • S4YY3V8YHD • UNII-S4YY3V8YHD
CAS Number: 6537-80-0
IUPAC Name: (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid
PubChem CID: 5281764

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Chicoric acid

Average/Median Lifespan
Max Lifespan
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References

Schlernitzauer, A et al. (2013) Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans. PLoS ONE 8(11)e78788 PubMed
Liu, YJ et al. (2019) Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet 15(3)e1007633 PubMed

DGIdb Human Drug-Gene Interactions for Chicoric acid

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Chicoric acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id