DrugAge entry for Carbidopa

Name: Carbidopa
Synonyms: (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid • (S)-(-)-carbidopa • (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid • (S)-carbidopa • 28860-95-9 • 28860-95-9 (anhydrous) • alpha-Methyldopahydrazine • carbidopa • Carbidopa (anhydrous) • Carbidopa anhydrous • Carbidopa hydrate • Carbidopum • Carbidopum [INN-Latin] • CHEBI:39585 • KR87B45RGH • L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid • L-alpha-Methyldopahydrazine • Lodosyn • MK 486 • MK-486 • N-Aminomethyldopa • S(-)-CARBIDOPA • S-(-)-Carbidopa • UNII-KR87B45RGH
CAS Number: 28860-95-9
IUPAC Name: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
PubChem CID: 34359

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Carbidopa

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Carbidopa

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Carbidopa

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id