DrugAge entry for Caffeine

Name
Caffeine 
Synonyms
1,3,7-Trimethylxanthine • 58-08-2 • 7-Methyltheophylline • Alert-pep • Cafamil • Cafecon • Cafeina • Caffedrine • Caffein • caffeine • Caffine • Cafipel • Coffeine • Dexitac • Eldiatric C • Guaranine • Koffein • Mateina • Methyltheobromine • No-Doz • Nodaca • Refresh'n • Stim • Thein • Theine 
CAS Number
58-08-2 
IUPAC Name
1,3,7-trimethylpurine-2,6-dione 
PubChem CID
2519 
SEP-L1000 side effects
Acidosis, Agitation, Blood creatinine increased, Cerebral haemorrhage, Cerebrovascular accident, Disseminated intravascular coagulation, Dry skin, Dyspnoea, Enterocolitis, Feeling jittery, Gastritis, Gastrointestinal haemorrhage, Haemorrhage, Hyperglycaemia, Hypoglycaemia, Impaired healing, Irritability, Necrotising colitis, Oedema, Pulmonary oedema, Rash, Renal failure, Retinal disorder, Sepsis, Skin disorder, Tachycardia 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Caffeine


References

Massie, HR et al. (1993) Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67(3)227-237 PubMed
Wanke, V et al. (2008) Caffeine extends yeast lifespan by targeting TORC1. Mol. Microbiol. 69(1)277-285 PubMed
Sutphin, GL et al. (2012) Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan 1()9 PubMed
Bridi, JC et al. (2015) Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. Front Aging Neurosci 7()220 PubMed
Hyung Joo Suh, et al. (2017) Behavioral Changes and Survival in Drosophila melanogaster: Effects of Ascorbic Acid, Taurine, and Caffeine Biological and Pharmaceutical Bulletin () PubMed
Du X, et al. (2018) Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway Frontiers in ageing neuroscience () PubMed

DGIdb Human Drug-Gene Interactions for Caffeine

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Caffeine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id