DrugAge entry for Caffeine
- Name
- Caffeine
- Synonyms
- 1,3,7-Trimethylxanthine • 58-08-2 • 7-Methyltheophylline • Alert-pep • Cafamil • Cafecon • Cafeina • Caffedrine • Caffein • caffeine • Caffine • Cafipel • Coffeine • Dexitac • Eldiatric C • Guaranine • Koffein • Mateina • Methyltheobromine • No-Doz • Nodaca • Refresh'n • Stim • Thein • Theine
- CAS Number
- 58-08-2
- IUPAC Name
- 1,3,7-trimethylpurine-2,6-dione
- PubChem CID
- 2519
- SEP-L1000 side effects
- Acidosis, Agitation, Blood creatinine increased, Cerebral haemorrhage, Cerebrovascular accident, Disseminated intravascular coagulation, Dry skin, Dyspnoea, Enterocolitis, Feeling jittery, Gastritis, Gastrointestinal haemorrhage, Haemorrhage, Hyperglycaemia, Hypoglycaemia, Impaired healing, Irritability, Necrotising colitis, Oedema, Pulmonary oedema, Rash, Renal failure, Retinal disorder, Sepsis, Skin disorder, Tachycardia
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Caffeine
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Massie, HR et al. (1993) Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67(3)227-237 PubMedWanke, V et al. (2008) Caffeine extends yeast lifespan by targeting TORC1. Mol. Microbiol. 69(1)277-285 PubMed
Sutphin, GL et al. (2012) Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan 1()9 PubMed
Bridi, JC et al. (2015) Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. Front Aging Neurosci 7()220 PubMed
Hyung Joo Suh, et al. (2017) Behavioral Changes and Survival in Drosophila melanogaster: Effects of Ascorbic Acid, Taurine, and Caffeine Biological and Pharmaceutical Bulletin () PubMed
Du X, et al. (2018) Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway Frontiers in ageing neuroscience () PubMed
Li, H et al. (2019) Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in Food Chem X 1()100005 PubMed
Teresia M. Njoroge (2021) Specific phytochemicals in floral nectar up-regulate genes involved in longevity regulation and xenobiotic metabolism, extending mosquito life span Ecology and Evolution 11(12)8363-8380 PubMed
DGIdb Human Drug-Gene Interactions for Caffeine
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Caffeine
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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