DrugAge entry for Caffeic acid

Name: Caffeic acid
Synonyms: (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid • (E)-3,4-dihydroxycinnamic acid • (E)-3-(3,4-dihydroxyphenyl)acrylic acid • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)- • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, (E)- • 3,4-Dihydroxy-trans-cinnamate • 3,4-Dihydroxybenzeneacrylic acid • 3,4-Dihydroxycinnamic acid • 3-(3,4-Dihydroxy phenyl)-2-propenoic acid • 3-(3,4-Dihydroxyphenyl)-2-propenoic acid • 3-(3,4-dihydroxyphenyl)acrylic acid • 3-(3,4-Dihydroxyphenyl)propenoic acid • 331-39-5 • 4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene • 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene • 501-16-6 • AI3-63211 • caffeic acid • CCRIS 847 • CHEMBL145 • Cinnamic acid, 3,4-dihydroxy- • EINECS 206-361-2 • HSDB 7088 • MFCD00004392 • NSC 57197 • trans-Caffeate • trans-caffeic acid • U2S3A33KVM • UNII-U2S3A33KVM
CAS Number: 331-39-5
IUPAC Name: (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
PubChem CID: 689043
SEP-L1000 side effects: Abdominal pain, Dermatitis, Diarrhoea, Dizziness, Dyspepsia, Dyspnoea, Erythema, Flushing, Headache, Hypersensitivity, Hypotension, Insomnia, Malaise, Nausea, Oedema, Pain, Pruritus, Rash, Tachycardia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Caffeic acid

Average/Median Lifespan
Max Lifespan
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References

Pietsch, K et al. (2011) Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. Biogerontology 12(4)329-347 PubMed
Gutierrez-Zetina, SM et al. (2021) Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance in Molecules 26(6) PubMed
Li, H et al. (2021) Caffeic acid protects against Aβ toxicity and prolongs lifespan in Food Funct 12(3)1219-1231 PubMed

DGIdb Human Drug-Gene Interactions for Caffeic acid

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Caffeic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id