DrugAge entry for Auraptene

Name: Auraptene
Synonyms: (E)-7-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-2H-chromen-2-one • 2H-1-Benzopyran-2-one, 7-((3,7-dimethyl-2,6-octadienyl)oxy)-, (E)- • 2H-1-Benzopyran-2-one, 7-[(3,7-dimethyl-2,6-octadienyl)oxy]-, (E)- • 495-02-3 • 7-([(2E)-3,7-Dimethyl-2,6-octadienyl]oxy)-2H-chromen-2-one • 7-Geranyloxycoumarin • 7-O-geranylumbelliferone • 7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one • 7-{[(2E)-3,7-dimethyl-2,6-octadienyl]oxy}-2H-chromen-2-one • 7-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-2H-chromen-2-one • Aurapten • Auraptene • CCRIS 8835 • CHEMBL307341 • Coumarin, 7-(geranyloxy)- • F79I1ZEL2E • Feronialactone • MEGxp0_000091 • MLS001049098 • SCHEMBL2535029 • SCHEMBL2535034 • SPECTRUM1505176 • SR-01000758940 • UNII-F79I1ZEL2E • UPCMLD-DP061
CAS Number: 495-02-3
IUPAC Name: 7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one
PubChem CID: 1550607

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Auraptene

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Auraptene

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Auraptene

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id