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DrugAge entry for Astaxanthin

Name
Astaxanthin 
Synonyms
(3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione • (3S,3'S)-all-trans-Astaxanthin • (3S,3'S)-Astaxanthin • (6S)-6-Hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexenyl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethyl-1-cyclohex-2-enone • (6S,6'S)-3,3'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(6-hydroxy-2,4,4-trimethylcyclohex-2-enone) • 3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione • 3,3'-Dihydroxy-beta-carotene-4,4'-dione • 3S,3'S-Astaxanthin • 472-61-7 • 8XPW32PR7I • Algae Haematococcus pluvialis • all-trans-Astaxanthin • AstaREAL • Astaxanthin • Astaxanthin (6CI) • Astaxanthin, (3S,3'S)- • Astaxanthin, all-trans- • Astaxanthine • BioAstin • BioAstin oleoresin • Carophyll Pink • CHEBI:40968 • Lucantin Pink • MQZIGYBFDRPAKN-UWFIBFSHSA-N • Natupink • Ovoester • trans-Astaxanthin • UNII-8XPW32PR7I 
CAS Number
472-61-7 
IUPAC Name
(6S)-6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxocyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethylcyclohex-2-en-1-one 
PubChem CID
5281224 

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Sex Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Astaxanthin


References

Yazaki, K et al. (2011) Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. Oxid Med Cell Longev 2011()596240 PubMed
Kashima, N et al. (2012) Development of a method for oral administration of hydrophobic substances to Caenorhabditis elegans: pro-longevity effects of oral supplementation with lipid-soluble antioxidants. Biogerontology 13(3)337-344 PubMed
Fu, M et al. (2020) Autophagy Plays a Role in the Prolongation of the Life Span of Rejuvenation Res () PubMed
Harrison, DE et al. (2024) Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. GeroScience 46(1)795-816 PubMed

DGIdb Human Drug-Gene Interactions for Astaxanthin

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Astaxanthin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id