DrugAge entry for Ascorbic acid
- Name
- Ascorbic acid
- Synonyms
- 50-81-7 • Allercorb • Ascoltin • Ascorbajen • ascorbate • ascorbic acid • Ascorbicap • Ascorbutina • Ascorteal • Cescorbat • Cetemican • Cevitamic acid • Cevitamin • Citriscorb • Hybrin • L(+)-Ascorbic acid • L-ascorbate • l-ascorbic acid • Laroscorbine • Lemascorb • Natrascorb • Proscorbin • Roscorbic • Secorbate • vitamin C
- CAS Number
- 50-81-7
- IUPAC Name
- (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
- PubChem CID
- 54670067
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Ascorbic acid
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Harrington, LA and Harley, CB (1988) Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech. Ageing Dev. 43(1)71-78 PubMedThomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed
Desjardins D, et al. (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell () PubMed
H. R. Massie (1976) Ascorbic acid and longevity in Drosophila Experimental Gerontology 11(1-2)37-41 PubMed
RS Sohal (1985) Effects of exogenous antioxidants on the levels of endogenous antioxidants, lipid-soluble fluorescent material and life span in the housefly, Musca domestica Mechanisms of Ageing and Development 31(3)329-336 PubMed
Harold R Massie (1991) Ascorbic acid in Drosophila and changes during aging Experimental Gerontology 26(5)487-494 PubMed
Harold R Massie (1984) Dietary vitamin C improves the survival of mice Gerontology 30(6)371-375 PubMed
DGIdb Human Drug-Gene Interactions for Ascorbic acid
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Ascorbic acid
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
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