DrugAge entry for Amoxapine

Name: Amoxapine
Synonyms: 14028-44-5 • 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine • Amoxan • Amoxapina • Amoxapina [INN-Spanish] • amoxapine • Amoxapine [USAN:BAN:INN:JAN] • Amoxapinum • Amoxapinum [INN-Latin] • Amoxepine • Ascendin • Asendin • Asendin (TN) • Asendis • CL 67772 • CL-67772 • Defanyl • Demolox • Desmethylloxapin • Desmethylloxapine • Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)- • EINECS 237-867-1 • KS-1197 • Moxadil • UNII-R63VQ857OT
CAS Number: 14028-44-5
IUPAC Name: 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
PubChem CID: 2170
SEP-L1000 side effects: Abdominal pain, Agitation, Agranulocytosis, Alopecia, Arrhythmia, Arrhythmia supraventricular, Asthenia, Ataxia, Atrial fibrillation, Atrioventricular block, Body temperature increased, Breast enlargement, Cardiac fibrillation, Cerebrovascular accident, Confusional state, Constipation, Convulsion, Coordination abnormal, Decreased appetite, Diarrhoea, Disorientation, Dizziness, Dry mouth, Dysgeusia, Dyskinesia, Dyspepsia, Eosinophilia, Erectile dysfunction, Extrapyramidal disorder, Fatigue, Flatulence, Galactorrhoea, Hallucination, Headache, Hepatitis, Hyperhidrosis, Hypertension, Hyperthermia, Hypertrophy, Hypoaesthesia, Hypomania, Hypotension, Ileus, Ileus paralytic, Inappropriate antidiuretic hormone secretion, Increased appetite, Infarction, Insomnia, Jaundice, Lacrimation increased, Leukopenia, Libido decreased, Menstruation irregular, Mydriasis, Myocardial infarction, Nasal congestion, Nausea, Nervousness, Neuroleptic malignant syndrome, Nightmare, Oedema, Pain, Palpitations, Pancreatitis, Paraesthesia,

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Amoxapine

Average/Median Lifespan
Max Lifespan
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References

Ye, X et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13(2)206-215 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for Amoxapine

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Amoxapine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id