DrugAge entry for Alpha-ketoglutarate
- Name
- Alpha-ketoglutarate
- Synonyms
- 2-ketoglutarate • 2-ketoglutaric acid • 2-Ketoglutaricacid • 2-Oxo-1,5-pentanedioic acid • 2-Oxo-Glutaric Acid • 2-oxoglutarate • 2-oxoglutaric acid • 2-Oxopentanedioic acid • 328-50-7 • AI3-26938 • alpha Ketoglutarate • alpha-ketoglutarate • alpha-ketoglutaric acid • alpha-Ketoglutaric acid alpha • alpha-Oxoglutaric acid • Alphaketoglutaric acid • Bis(L-arginin)-2-oxoglutarat • Glutaric acid, 2-oxo- • Glutaric acid, alpha keto • NSC 17391 • Oxoglutarate • Oxoglutaric acid • Pentanedioic acid, 2-oxo- • Pentanedioic acid, oxo- • UNII-8ID597Z82X
- CAS Number
- 328-50-7
- IUPAC Name
- 2-oxopentanedioic acid
- PubChem CID
- 51
Summary
| Species | No. Entries | MAX(Avg/Med Lifespan Change %) | MEAN(Avg/Med Lifespan Change %) | MAX(Max Lifespan Change %) | MEAN(Max Lifespan Change %) |
|---|
Results
| Compound/Formulation | Species | Sex | Strain | Dosage | Avg/Med Lifespan Change (%) | Avg/Med Lifespan Significance | Max Lifespan Change (%) | Reference |
|---|
Lifespan Charts for Alpha-ketoglutarate
- Average/Median Lifespan
- Max Lifespan
- Hide Charts
References
Chin, RM et al. (2014) The metabolite \u03b1-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510(7505)397-401 PubMedEdwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16()8 PubMed
Fu, X et al. (2015) 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 22(3)508-515 PubMed
Su, Y et al. (2019) Alpha-ketoglutarate extends Aging (Albany NY) 11(12)4183-4197 PubMed
Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed
Banse, SA et al. (2019) Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions. Geroscience 41(6)945-960 PubMed
Asadi Shahmirzadi, A et al. (2020) Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab 32(3)447-456.e6 PubMed
Miller, RA et al. (2024) Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. GeroScience 46(5)4657-4670 PubMed
DGIdb Human Drug-Gene Interactions for Alpha-ketoglutarate
| Interaction Types | Gene Symbol | Common Name | HGNC Id | DGIdb Sources | References |
|---|---|---|---|---|---|
Stitch DB Human Drug-Protein Interactions for Alpha-ketoglutarate
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.
| Ensembl Id | StringDB Id |
|---|