DrugAge entry for Allantoin

Name: Allantoin
Synonyms: (2,5-Dioxo-4-imidazolidinyl)urea • (2,5-dioxoimidazolidin-4-yl)urea • 1-(2,5-dioxoimidazolidin-4-yl)urea • 5-Ureido-2,4-imidazolidindion • 5-Ureidohydantoin • 97-59-6 • Alantan • allantoin • Allantol • AVC/Dienestrolcream • Caswell No. 024 • Cordianine • Cutemol emollient • Glyoxyldiureid • Glyoxyldiureide • Glyoxylic diureide • Glyoxylic(acid) diureide • Hydantoin, 5-ureido- • NSC 7606 • Psoralon • Sebical • Septalan • Uniderm A • Urea, (2,5-dioxo-4-imidazolidinyl)- • Ureidohydantoin
CAS Number: 97-59-6
IUPAC Name: (2,5-dioxoimidazolidin-4-yl)urea
PubChem CID: 204
SEP-L1000 side effects: Abdominal pain, Anaemia, Asthenia, Body temperature increased, Confusional state, Constipation, Diarrhoea, Dizziness, Erythema, Haemorrhage, Headache, Leukopenia, Malaise, Nausea, Oedema, Pain, Pruritus, Rash, Somnolence, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Allantoin

Average/Median Lifespan
Max Lifespan
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References

Calvert, S et al. (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15(2)256-266 PubMed
Admasu, TD et al. (2018) Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. Dev Cell 47(1)67-79.e5 PubMed

DGIdb Human Drug-Gene Interactions for Allantoin

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Allantoin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id