DrugAge entry for Acetaminophen

Name: Acetaminophen
Synonyms: 103-90-2 • 4'-Hydroxyacetanilide • 4-Acetamidophenol • Abensanil • Acamol • Acenol • Acetagesic • Acetalgin • Acetaminofen • acetaminophen • Algotropyl • Anelix • APAP • Datril • Lonarid • Multin • N-(4-Hydroxyphenyl)acetamide • N-Acetyl-p-aminophenol • Naprinol • p-Acetamidophenol • p-Acetaminophenol • p-Hydroxyacetanilide • Panadol • Paracetamol • Tylenol
CAS Number: 103-90-2
IUPAC Name: N-(4-hydroxyphenyl)acetamide
PubChem CID: 1983
SEP-L1000 side effects: Abdominal pain, Agitation, Anaemia, Angiopathy, Anxiety, Aspartate aminotransferase increased, Atelectasis, Breath sounds abnormal, Cardiac disorder, Connective tissue disorder, Constipation, Diarrhoea, Dyspnoea, Effusion, Fatigue, Fluid overload, Gastrointestinal disorder, Hypersensitivity, Hypertension, Hypoalbuminaemia, Hypokalaemia, Hypomagnesaemia, Hypophosphataemia, Hypotension, Hypoxia, Injection site pain, Insomnia, Mediastinal disorder, Mental disorder, Muscle spasms, Nausea, Nervous system disorder, Oedema, Oedema peripheral, Oliguria, Pain in extremity, Periorbital oedema, Pleural disorder, Pleural effusion, Pruritus, Pulmonary oedema, Rash, Stridor, Tachycardia, Trismus, Urinary tract disorder, Vomiting, Wheezing

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Acetaminophen

Average/Median Lifespan
Max Lifespan
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References

Lublin, A et al. (2011) FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS ONE 6(11)e27762 PubMed
Hochschild, R. (1971) Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster. Exp Gerontol 6(2)133-151 PubMed
Hochschild R. (1973) Effects of various drugs on longevity in female C57BL-6J mice Gerontologia () PubMed

DGIdb Human Drug-Gene Interactions for Acetaminophen

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Acetaminophen

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id