DrugAge entry for Acarbose

Name: Acarbose
Synonyms: 56180-94-0 • AC1L26GM • Acarbosa [INN-Spanish] • acarbose • Acarbose [USAN:BAN:INN:JAN] • Acarbosum • Acarbosum [INN-Latin] • Ascarbose • Bay g 5421 • BAY-g 5421 • BB_NC-1311 • C25H43NO18 • CHEBI:2376 • CHEMBL3734896 • Glucobay • HMS2051F03 • HMS2093I22 • MFCD00869592 • MLS000759506 • MLS001424056 • MolPort-002-507-369 • Prandase • Precose • Precose (TN) • SPECTRUM1505172
CAS Number: 56180-94-0
IUPAC Name: (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol
PubChem CID: 41774
SEP-L1000 side effects: Abdominal pain, Diarrhoea, Dyspepsia, Erythema, Flatulence, Gastrointestinal disorder, Hepatic enzyme increased, Hepatic function abnormal, Hepatitis, Hepatitis fulminant, Hepatocellular injury, Ileus, Jaundice, Liver function test abnormal, Nausea, Oedema, Pain, Rash, Shock, Thrombocytopenia, Urticaria, Vomiting

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for Acarbose

Average/Median Lifespan
Max Lifespan
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References

Harrison, DE et al. (2014) Acarbose, 17-\u03b1-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13(2)273-282 PubMed
Strong R, et al. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer Aging Cell () PubMed
Harrison, DE et al. (2019) Acarbose improves health and lifespan in aging HET3 mice. Aging Cell 18(2)e12898 PubMed

DGIdb Human Drug-Gene Interactions for Acarbose

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for Acarbose

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id