DrugAge entry for 5-Hydroxy-L-tryptophan

Name: 5-Hydroxy-L-tryptophan
Synonyms: (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid • (S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid • 4350-09-8 • 5-HTP • 5-hydroxy-L-tryptophane • 5-Hydroxyl-L-tryptophan • 5-Hydroxytryptophan L-form • Cincofarm • L-5-Htp • L-5-Hydroxytryptophan • Levothym • oxitriptan • Oxitriptan [INN] • Oxyfan • Pretonine • Quietim • Serotonyl • Telesol • Tript-OH • Tryptophan, 5-hydroxy-
CAS Number: 4350-09-8
IUPAC Name: (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
PubChem CID: 439280

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for 5-Hydroxy-L-tryptophan

Average/Median Lifespan
Max Lifespan
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References

Lombard, DB et al. (2020) High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance. Sci Adv 6(40) PubMed

DGIdb Human Drug-Gene Interactions for 5-Hydroxy-L-tryptophan

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for 5-Hydroxy-L-tryptophan

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id