DrugAge entry for 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone

Name: 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone
Synonyms: 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one • 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one • 2174-59-6 • 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy- • 5-demethyl nobiletin • 5-Demethylnobiletin • 5-Desmethoxynobiletin (incorr.) • 5-Hydroxy-3',4',6,7,8-pentamethoxyflavone • 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone • 5-O-Demethylnobiletin • 5-O-Desmethylnobiletin • CHEBI:175933 • CHEMBL75978 • Demethylnobiletin • DTXSID60176134 • HY-N1942 • OGE0V42MOT • SCHEMBL1764120 • SPECTRUM1505030 • UNII-OGE0V42MOT
CAS Number: 2174-59-6
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
PubChem CID: 358832

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone

Average/Median Lifespan
Max Lifespan
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References

Trivedi, S and Pandey, R (2021) 5'-Hydroxy-6, 7, 8, 3', 4'-pentamethoxyflavone extends longevity mediated by DR-induced autophagy and oxidative stress resistance in C. elegans. Geroscience 43(2)759-772 PubMed

DGIdb Human Drug-Gene Interactions for 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for 5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id