DrugAge entry for 2,5-Di-tert-butylhydroquinone

Name: 2,5-Di-tert-butylhydroquinone
Synonyms: 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)- • 1,4-Dihydroxy-2,5-di-tert-butylbenzene • 2,5-Di-t-butylhydroquinone • 2,5-Di-tert-butyl-1,4-benzenediol • 2,5-Di-tert-butyl-1,4-benzohydroquinone • 2,5-Di-tert-butyl-1,4-hydroquinone • 2,5-Di-tert-butylbenzene-1,4-diol • 2,5-Di-tert-butylhydroquinone • 2,5-Di-tert-butylquinol • 2,5-DITERT-BUTYLBENZENE-1,4-DIOL • 88-58-4 • Antage DBH • bhq • Di-t-butylhydroquinone • di-tert-butylhydroquinone • Dibug • DTBHQ • Dybug • MFCD00008825 • Naugard 451 • Nocrac NS 7 • Nonflex Alba • NSC 11 • Santovar O • t-BuBHQ • UNII-26XK13B61B
CAS Number: 88-58-4
IUPAC Name: 2,5-ditert-butylbenzene-1,4-diol
PubChem CID

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for 2,5-Di-tert-butylhydroquinone

Average/Median Lifespan
Max Lifespan
Hide Charts

References

García-Casas, et al. (2018) Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms Frontiers in pharmacology () PubMed
García-Casas, P et al. (2021) Mechanism of the lifespan extension induced by submaximal SERCA inhibition in C. elegans. Mech Ageing Dev 196()111474 PubMed

DGIdb Human Drug-Gene Interactions for 2,5-Di-tert-butylhydroquinone

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for 2,5-Di-tert-butylhydroquinone

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id