DrugAge entry for 17‐alpha‐estradiol

Name: 17‐alpha‐estradiol
Synonyms: 17-alpha-estradiol
CAS Number: 57-91-0
IUPAC Name: (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
PubChem CID: 68570

Summary

Species	No. Entries	MAX(Avg/Med Lifespan Change %)	MEAN(Avg/Med Lifespan Change %)	MAX(Max Lifespan Change %)	MEAN(Max Lifespan Change %)

Results

Compound/Formulation	Species	Sex	Strain	Dosage	Avg/Med Lifespan Change (%)	Avg/Med Lifespan Significance	Max Lifespan Change (%)	Reference

Lifespan Charts for 17‐alpha‐estradiol

Average/Median Lifespan
Max Lifespan
Hide Charts

References

Harrison, DE et al. (2014) Acarbose, 17-\u03b1-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13(2)273-282 PubMed
Strong R, et al. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer Aging Cell () PubMed
David E. Harrison (2021) 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex Aging Cell 20(5)e13328 PubMed

DGIdb Human Drug-Gene Interactions for 17‐alpha‐estradiol

Interaction Types	Gene Symbol	Common Name	HGNC Id	DGIdb Sources	References

Stitch DB Human Drug-Protein Interactions for 17‐alpha‐estradiol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id	StringDB Id