Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: PNC1

Gene Information (Entrez Gene ID: 852846)

Symbol
PNC1
Name
Pyrazinamidase/NiCotinamidase 1
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
852846

Potential relevance to dietary restriction and ageing

Observations

Cells with 5 copies of PNC1 have a 70% longer replicative lifespan which is cancelled out by SIR2 deletion. PNC1 is upregulated under glucose DR [2499]. Deletion of PNC1 shortens replicative lifespan approximately by 10% [2499] and largely prevents replicative lifespan extension of 0.5% glucose restriction. 0.5% glucose restriction slightly extends median replicative lifespan (by 10 - 15%) but not maximum replicative lifespan in pnc1Delta [2329]. Increased expression of PNC1 is both necessary and sufficient for replicative lifespan extension by DR and low-intensity stress. DR does not further increase the lifespan of the 5XPNC1 strain [2499].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as pnc-1
    • A homolog of this gene for Drosophila melanogaster is present as Naam
    • This gene is present as PNC1
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as pnc-1

    Homologs

    Caenorhabditis elegans
    pnc-2
    Caenorhabditis elegans
    pnc-1
    Drosophila melanogaster
    Naam
    Schizosaccharomyces pombe
    pnc1

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    ID 852846
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar