Cell Senescence Entries for GATA4
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- BJ, IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Kang et al. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349(6255)aaa5612 (PubMed)
GATA4 Gene Information
- HGNC symbol
- GATA4
- Aliases
- Common name
- GATA binding protein 4
- Entrez Id
- 2626
- Description
- This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
GATA4 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:8584; male gonad development
GO:45766; positive regulation of angiogenesis
GO:3281; ventricular septum development
GO:1947; heart looping
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:45165; cell fate commitment
And 39 more GO terms Cellular component: GO:5634; nucleus
GO:16604; nuclear body
GO:785; chromatin
GO:5654; nucleoplasm
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
And 9 more GO terms
Homologs of GATA4 in Model Organisms
- Danio rerio
- gata4
- Drosophila melanogaster
- pnr
- Mus musculus
- Gata4
- Rattus norvegicus
- Gata4
- Saccharomyces cerevisiae
- GLN3
- Saccharomyces cerevisiae
- DAL80
- Saccharomyces cerevisiae
- GZF3
- Saccharomyces cerevisiae
- GAT1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as GLN3
- LongevityMap
- This gene is present as GATA4
External links
- OMIM
- 600576
- Ensembl
- ENSG00000136574
- Entrez Gene
- 2626
- UniGene
- 243987
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GATA4
- GeneCards
- GATA4