LongevityMap Gene

Gene details

HGNC symbol: GATA4
Aliases: TOF; ASD2; VSD1; TACHD
Common name: GATA binding protein 4
Description: This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Cytogenetic Location: 8p23.1
UCSC Genome Browser: View 8p23.1 on the UCSC genome browser
OMIM: 600576
Ensembl: ENSG00000136574
UniProt/Swiss-Prot: B3KUF4_HUMAN
Entrez Gene: 2626
UniGene: 243987
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: gata4
Drosophila melanogaster: pnr
Mus musculus: Gata4
Rattus norvegicus: Gata4
Saccharomyces cerevisiae: GLN3
Saccharomyces cerevisiae: DAL80
Saccharomyces cerevisiae: GZF3
Saccharomyces cerevisiae: GAT1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as GLN3

CellAge

This gene is present as GATA4

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference