LongevityMap variant group
Atzmon et al. (2009)
- Longevity Association
- Ashkenazi Jewish
- Study Design
- TSH heritability, its distribution, and association with SNPs in the TSH-B and TSHR genes was determined in Ashkenazi Jewish centenarians (n = 232; median age, 97 yr), their offspring (n = 366; median age, 69 yr), and age-matched controls without familial longevity (n = 163; median age, 70 yr)
- A heritable phenotype characterized by raised serum TSH is associated with human longevity. Allele frequency of two SNPs in the promoter/enhancer region of TSHR gene (rs12050077 and rs10149689), associated with increased serum TSH, was higher in centenarians and their offspring compared to controls.
Other variants which are also part of this study