A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.
Adiponectin levels and variants in the adiponectin gene (ADIPOQ) were studied in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78)
Conclusions
Frequencies were not significantly different between probands and controls, though there was a suggestive difference in rs17300539 and APM1+2019 between male probands versus controls
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
