LongevityMap variant
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish, Czechs (Bohemian)
- Study Design
- 525 Ashkenazi Jews composed of 216 probands (age ≥95 years) and 309 unrelated individuals (ages 51 to 94) were genotyped for the functional variant of KLOTHO, termed KL-VS. 435 elderly individuals (≥75 years) were genotyped.
- Conclusions
- A common variant of KLOTHO, the KL-VS allele, was associated with human longevity. A heterozygous advantage for longevity was observed for individuals ≥79 years of age (P<0.004).
- HGNC symbol
- KL
- Aliases
-
- Common name
- klotho
- Description
- This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 604824
- Ensembl
- ENSG00000133116
- UniProt/Swiss-Prot
- KLOT_HUMAN
- Entrez Gene
- 9365
- UniGene
- 524953
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- klo-2
- Caenorhabditis elegans
- klo-1
- Danio rerio
- kl
- Mus musculus
- Kl
- Rattus norvegicus
- Kl
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Kl
- A homolog of this gene for Caenorhabditis elegans is present as klo-1
- A homolog of this gene for Caenorhabditis elegans is present as klo-2
- GenAge human genes
- This gene is present as KL
- CellAge
- This gene is present as KL
Arking et al. (2005)
Other variants which are also part of this study
