LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Italian
Study Design: C3 alleles were examined in healthy aged people (77 centenarians and 89 elderly subjects)
Conclusions: The frequencies of C3 alleles were similar in the studied cohorts

HGNC symbol: C3
Aliases: ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Common name: complement C3
Description: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
OMIM: 120700
Ensembl: ENSG00000125730
UniProt/Swiss-Prot: B4DR57_HUMAN
Entrez Gene: 718
UniGene: 529053
HapMap: View on HapMap

GenAge microarray genes

CellAge gene expression

Bellavia et al. (1999)