LongevityMap variant
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- 291 SNPs in 30 genes in the insulin/IGF1 signaling pathway were evaluated in 293 long-lived cases and 603 average-lifespan controls (all female), then replicated the candidate genes in two independent cohorts: 279 cases (47% male vs 797 controls(52.6% male) and 383 cases (25.2% male) vs 363 controls (42.7 % male)
- Conclusions
- rs3803304 in AKT1 was significantly associated with longevity from a meta-analysis result (odds ratio (OR)=0.78 (95% confidence interval (CI)=0.68-0.89), adjusted p=0.043)
- HGNC symbol
- AKT1
- Aliases
- AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
- Common name
- AKT serine/threonine kinase 1
- Description
- The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Other longevity studies of this gene
- 9
- OMIM
- 164730
- Ensembl
- ENSG00000142208
- UniProt/Swiss-Prot
- AKT1_HUMAN
- Entrez Gene
- 207
- UniGene
- 525622
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- akt-2
- Caenorhabditis elegans
- akt-1
- Danio rerio
- AKT1
- Drosophila melanogaster
- Akt1
- Mus musculus
- Akt1
- Rattus norvegicus
- Akt1
- Saccharomyces cerevisiae
- SCH9
- Saccharomyces cerevisiae
- YPK1
- Saccharomyces cerevisiae
- YPK2
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as akt-1
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- A homolog of this gene for Drosophila melanogaster is present as Akt1
- A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
- A homolog of this gene for Mus musculus is present as Akt1
- GenAge human genes
- This gene is present as AKT1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- CellAge
- This gene is present as AKT1
Pawlikowska et al. (2009)
Other variants which are also part of this study
