Cell Senescence Entries for AKT1

Cell Types
Aortic endothelial, Umbilical vein endothelial, Dermal microvascular endothelial cells
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Expression of constitutively activated AKT1 in endothelial cells promoted senescence-like growth arrest with the cells displaying enlarged, flattened morphology and increased SA-beta-galactosidase activity. This senescence effect was dependent on the p53/p21 pathway.
Primary Reference

    AKT1 Gene Information

    HGNC symbol
    AKT1 
    Aliases
    AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA 
    Common name
    AKT serine/threonine kinase 1 
    Entrez Id
    207
    Description
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

    AKT1 Ontologies

    Gene Ontology
    Process: GO:7186; G-protein coupled receptor signaling pathway
    GO:82; G1/S transition of mitotic cell cycle
    GO:7249; I-kappaB kinase/NF-kappaB signaling
    GO:38061; NIK/NF-kappaB signaling
    GO:31295; T cell costimulation
    GO:31929; TOR signaling
    GO:6924; activation-induced cell death of T cells
    GO:7568; aging
    GO:43276; anoikis
    GO:8637; apoptotic mitochondrial changes
    GO:30154; cell differentiation
    And 120 more GO terms
    Cellular component: GO:5911; cell-cell junction
    GO:36064; ciliary basal body
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:15630; microtubule cytoskeleton
    GO:5739; mitochondrion
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:98794; postsynapse
    GO:43234; protein complex
    And 3 more GO terms
    Function: GO:71889; 14-3-3 protein binding
    GO:5524; ATP binding
    GO:32794; GTPase activating protein binding
    GO:19899; enzyme binding
    GO:42802; identical protein binding
    GO:16301; kinase activity
    GO:30235; nitric-oxide synthase regulator activity
    GO:5547; phosphatidylinositol-3,4,5-trisphosphate binding
    GO:43325; phosphatidylinositol-3,4-bisphosphate binding
    GO:5515; protein binding
    GO:5080; protein kinase C binding
    And 5 more GO terms
    Show all GO terms

    Homologs of AKT1 in Model Organisms

    Mus musculus
    Akt1
    Rattus norvegicus
    Akt1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Akt1
    GenAge human genes
    • This gene is present as AKT1
    LongevityMap
    • This gene is present as AKT1

    External links

    OMIM
    164730
    Ensembl
    ENSG00000142208
    Entrez Gene
    207
    UniGene
    525622
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    AKT1
    GeneCards
    AKT1