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| Gene symbol |
Name |
Genomic location |
Population |
Study design |
Conclusions |
Reference |
External links |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 9q31.1 | Japanese | The R219K SNP was examined in 256 centenarians and 190 healthy younger controls | The allelic frequencies were not different between the two groups | Arai et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | French | I/D polymorphism was examined in centenarians (n = 338) and in adults aged 20-70 years | A variant of ACE which predisposes to coronary heart disease was more frequent in centenarians with a significant increase of the homozygous genotype | Schachter et al., 1994 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | English, Cambridge | I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years | The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women. | Galinsky et al., 1997 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Copenhagen, Denmark | ACE (I/D) polymorphism was examined in 10,150 subjects from 20 to >80 years-old | The relative frequency of the D allele did not change as a function of age | Agerholm-Larsen et al., 1997 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | French | I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women) | Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology | Faure-Delanef., 1998 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Dutch, Leiden | I/D polymorphism was determined in 648 subjects >85 years-old | The ACE genotype distributions were similar in elderly and young subjects | Heijmans et al., 1999 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Danish | I/D polymorphism was examined in 187 centenarians and 201 controls (20-64 years) | No significant differences relative to longevity were found | Bladbjerg et al., 1999 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | American Caucasians, USA | I/D polymorphism was examined in 2689 healthy Caucasians: 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females) | No statistically significant decrease in genotype or allele frequency was observed among carriers of ACE D | Hessner et al., 2001 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | French | I/D polymorphism was examined in 560 centenarians and 560 adult controls | No association was observed between ACE allele frequencies or genotype and longevity | Blanche et al., 2001 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Danish | The I/D polymorphisms were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | No significant differences relative to longevity were found | Tan et al., 2001 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Polish | I/D polymorphism was examined in 101 long-life subjects and in a group of 494 younger persons | No connection was made between polymorphism and long-life | Grzeszczak et al., 2002 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Uighur, Kazakh and Han, Xin Jiang Uighur Autonomous region of China | I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. | Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly. | Rahmutula et al., 2002 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Brazilian population of European and Japanese origin | I/D polymorphism was examined in 834 persons aged 10104 years | An association between the DD genotype and D allele and age was observed in the European group only. The ACE polymorphismage association occurred at age >60 years in the European population with decreasing II frequency. | Da Cruz et al., 2003 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Danish | The cognitive skills of 684 twins aged 73+ years were examined in relation to a polymorphic 287 bp fragment in the ACE gene that can be present in the insertion (I) variant and absent in the deletion (D) variant | Neither physical nor cognitive performance was associated with the ACE genotype. Having the D allele, however, improved the chances of survival. | Fredericsen et al., 2003 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Korean | I/D polymorphism was examined in 103 centenarians (13 men and 90 women) and in 7232 apparently healthy adults (4100 men and 3132 women) | The frequencies of genotypes and alleles of the centenarians were not significantly different from those of the control groups. There was also a lack of association between the presence of the D allele and dementia status. | Choi et al., 2003 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Northern and Southern Europe | I/D polymorphism was examined in 82 centenarians and 252 middle-aged, unrelated subjects or volunteers | No statistically significant differences were found in ACE genotype or allele frequencies between centenarians and controls in Southern European population | Panza et al., 2003 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Russian, Novosibirsk | I/D polymorphism was examined in 97 elderly subjects and control group aged 25-64 | Frequency of D/D genotype among senile and long-living men was significantly lower than in men 55-64 years of age. A similar decrease of this gene frequency was also found in women of the same age. | Shabalin et al., 2003 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Xinjiang Uygur people, China | I/D polymorphisms of ACE gene were examined in 42 centenarians, 102 people aged 90-99, 70 people aged 65-70, and 53 cases of natural death aged 65-70 used as controls | The frequency rates of genotype D/D and D alleles were significantly higher in the centenarian group than in the controls | Wufuer et al., 2004 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Italian | The genotype and allele frequency distribution of I/D polymorphisms were analyzed in 235 Italian patients with sporadic Alzheimer disease, 153 with familial Alzheimer disease, 192 healthy controls and 111 centenarians | There were no significant differences in ACE genotypes or allele frequencies in all the studied groups. Centenarians show the highest allele D frequency, although the value is not significant. | Nacmias et al., 2006 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Columbian | Polymorphisms in the ACE gene were analyzed in a sample of 538 subjects (18-106 years) | A significant decrease in DD genotype (24 vs. 16%) was observed between young and old subject groups (mean age: 45 vs. 77 years). The ACE DD genotype and D allele decrease was significant only in women. | Forrero et al., 2006 | Entrez Gene Ensembl HapMap |
| ACE | Angiotensin I-Converting Enzyme | 17q23.3 | Southern Italian | The association of sex and age with the occurrence of ACE genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians was examined | A significant association of D allele and age was observed in centenarians | Seripa et al., 2006 | Entrez Gene Ensembl HapMap |
| AGT | Angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) | 1q42.2 | Danish | M/T235 SNP was examined in 187 centenarians and 201 controls (20-64 years) | No significant differences relative to longevity were found | Bladbjerg et al., 1999 | Entrez Gene UniGene Ensembl HapMap |
| AGT | Angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) | 1q42.2 | Danish | M/T235 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | Significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele | Tan et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| APOA1 | Apolipoprotein A-I | 11q23.3 | Southern Italy | APOA1-MspI-RFLP (-75 nt from the transcription starting site) polymorphism was examined in a healthy population with 304 subjects aged 1845 years, 267 subjects aged 4680 years and 229 subjects aged 81109 years (including 184 subjects, 43 males and 141 females, older than 100 years) | The APOA1 allele P, which increases serum LDL-C at middle-age and is over-represented in cardiovascular diseases, tends to increase its frequency in the centenarians males | Garasto et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| APOA4 | Apolipoprotein A-IV | 11q23.3 | Italian | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 1959 years of age, mean 35.7 years) | The Hinf347 genotype distribution was significantly different in centenarians | Pepe et al., 1998 | Entrez Gene UniGene Ensembl HapMap |
| APOA4 | Apolipoprotein A-IV | 11q23.3 | French | Glutamine (CAG) to histidine (CAT) substitution at codon 360 was examined in 120 Alzheimer patients (88 females, 32 males) and 119 presumed-healthy elderly subjects (62 females, 57 males) | The frequency of apoAIV alleles was not significantly different between Alzheimer patients and the elderly control group. However, in both groups, apoAIV (360:His) allele frequency was higher than in the general population. | Merched et al., 1998 | Entrez Gene UniGene Ensembl HapMap |
| APOA4 | Apolipoprotein A-IV | 11q23.3 | Southern Italy | APOA4-HincII-RFLP (Asp127/Ser127) polymorphism was examined in a healthy population with 304 subjects aged 1845 years, 267 subjects aged 4680 years and 229 subjects aged 81109 years (including 184 subjects, 43 males and 141 females, older than 100 years) | No significant differences relative to longevity were found | Garasto et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| APOB | Apolipoprotein B (including Ag(x) antigen) | 2p24.1 | Finnish | The apolipoprotein B Xba I polymorphism was examined in 179 Finnish centenarians | The frequencies of the Xba I alleles among the centenarians and among the young Finns were not significantly different | Louhija et al., 1994 | Entrez Gene UniGene Ensembl HapMap |
| APOB | Apolipoprotein B (including Ag(x) antigen) | 2p24.1 | Finnish | The apolipoprotein B EcoRI and Xba I polymorphisms were examined in Finnish nonagenarians | The frequency of EcoRI allele R- was low in the nonagenarians, whereas the allele frequency for the Xba I polymorphism did not differ between the nonagenarians and the younger groups | Kervinen et al., 1994 | Entrez Gene UniGene Ensembl HapMap |
| APOB | Apolipoprotein B (including Ag(x) antigen) | 2p24.1 | Italian | A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms | Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls | de Benedictis et al., 1997 | Entrez Gene UniGene Ensembl HapMap |
| APOC1 | Apolipoprotein C-I | 19q13.31 | English, Cambridge | Allele and genotype frequencies at Hpa1 RFLP were examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years | Allele and genotype frequencies were significantly different in the elderly women compared to the younger sample. No difference was observed in the elderly men. | Galinsky et al., 1997 | Entrez Gene Ensembl HapMap |
| APOC3 | Apolipoprotein C-III | 11q23.3 | Finnish | The Sst I polymorphism was examined in 179 Finnish centenarians | The S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%) | Louhija et al., 1994 | Entrez Gene UniGene Ensembl HapMap |
| APOC3 | Apolipoprotein C-III | 11q23.3 | Russian | 5'-untranslated region (T-455C) SNP was examined in a group of 137 elderly individuals (70-106 years old) | A greater frequency of the -455C allele was demonstrated with aging | Anisimov et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| APOC3 | Apolipoprotein C-III | 11q23.3 | Southern Italian | APOC3-SstI-RFLP polymorphism was examined in a healthy population of 304 subjects aged 1845 years, 267 subjects aged 4680 years and 229 subjects aged 81109 years (including 184 subjects, 43 males and 141 females, older than 100 years) | No significant differences relative to longevity were found | Garasto et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| APOC3 | Apolipoprotein C-III | 11q23.3 | Ashkenazi Jews | A group of centenarians (213), their offspring (216), and an age-matched control group (258) were genotyped for 66 polymorphisms in 36 candidate genes related to cardiovascular disease | The prevalence of homozygosity for the 641C allele in the APOC3 promoter (rs2542052) was higher in centenarians (25%) and their offspring (20%) than in controls (10%). This genotype was associated with significantly lower serum levels of APOC3, a favorable pattern of lipoprotein levels and sizes. A lower prevalence of hypertension and greater insulin sensitivity in the 641C homozygotes was also found. | Atzmon et al., 2006 | Entrez Gene UniGene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Swedish | Isoforms were examined in 407 healthy Swedish individuals, 244 men and 163 women, ages 17 to 86 years | The E4 frequency decreased with increasing age and was significantly lower in individuals > 60 years of age | Eggertsen et al., 1993 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | French | Common polymorphism was examined in centenarians (n = 338) and in adults aged 20-70 years | E4 allele was significantly less frequent in centenarians than in controls, while the frequency of the E2 allele was significantly increased | Schachter et al., 1994 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Finnish | The common polymorphism of apolipoprotein E (E2, E3, and E4) was examined in 179 Finnish centenarians | The frequency of the E2 allele was higher and that of the E4 allele lower in the centenarians | Louhija et al., 1994 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Finnish | The common polymorphism of apolipoprotein E (E2, E3, and E4) was examined in Finnish nonagenarians | The frequency of the E4 allele was lower in the nonagenarians than in the middle-aged and young adults | Kervinen et al., 1994 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Italian | Polymorphism (E2, E3, and E4) was examined in a sample of 228 healthy Italian subjects (124 men and 104 women) aged 18-93 | The frequency of E4 decreased with age and was not found in subjects aged 75 and older | Ruiu et al., 1995 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | English, Cambridge | Common polymorphism was examined in 182 women and 100 men aged > 84 years and in 100 boys and 100 girls younger than 17 years | Difference between genotypes in the elderly women and the young sample was observed. However, this did not retain significance when the genotype frequencies of the young sample were adjusted to values expected from the allele frequencies on the basis of Hardy-Weinberg equilibrium and compared to observed genotypes in elderly men and women. | Galinsky et al., 1997 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | French | Polymorphism (E2, E3, and E4) was examined in 560 centenarians and 560 adult controls | Significant differences were observed between centenarians and controls for allelic and genotypic frequencies. The E4E4 genotype was under-represented in centenarians compared to controls. Centenarians carrying at least one E2 allele or homozygous for E3 were more frequent than controls. | Blanche et al., 2001 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Uygur nationality in Xinjiang China | Polymorphism (E2, E3, and E4) was studied in 164 subjects including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction | There was statistically significant difference in the E4 allele frequencies among the three groups with the older group showing a lower E4 allele frequency | Wang et al., 2001 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Finnish | Common polymorphism was examined in 179 persons (28 men and 151 women) aged 100 years and older | The percentages of E2-allele carriers increased with age, particularly in women. The percentage of carriers of the E4 allele was lower than expected. | Frisoni et al., 2001 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Brazilian | Common polymorphism was examined in 70 elderly patients aged 80 years or more | No association was observed between the genotypes and longevity, though individuals with the E3E4 genotype had a mean age greater than those with the E3E3 genotype. | Schwanke et al., 2002 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Russian, Novosibirsk | Common polymorphism was examined in 97 elderly subjects and control group aged 25-64 | In men aged 83 years and older the frequency of the E3/E4 genotype was lower and that of the E2/E3 genotype was higher. In subjects of senile age and long-livers of both sexes genotype E4/E4 was not found. | Shabalin et al., 2003 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Korean | Common polymorphism was examined in 103 centenarians (13 men and 90 women, mean age 102.4 +/- 2.6 years) and in 6435 adults (5008 men and 1427 women) of mean age 50.7 +/- 7.9 years | The frequencies of genotypes and alleles of the centenarians were not significantly different from those of the control groups. The frequency of the E4 allele was significantly higher in centenarians with dementia than in centenarians without definitive dementia. | Choi et al., 2003 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Ashkenazi Jews, Jerusalem | Common polymorphism was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years) | Ashkenazi older subjects were characterized by an increased percentage of the E2 allele and a decreased percentage of the E4 allele | Stessman et al., 2005 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Uygur nationality in Xinjiang China | Common polymorphism was examined in centenarians (n=42), 90-year-old people (n=102), 65-70-year-old people (n=70) and controls(n=53). | The frequencies of genotype E3/4 and E4, E3 alleles in the centenarian group were significantly lower than those in controls, whereas the frequencies of genotype E2/3 and E2 allele in the centenarian group were significantly higher than those in controls. | Mayila et al., 2005 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Columbian | Polymorphisms were studied in a sample of 538 Colombian subjects (aged 18-106 years) | There were no differences between young and old subjects | Forrero et al., 2006 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Southern Italian | The association of sex and age with the occurrence of APOE genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians was examined | A higher E2 frequency was observed in men aged 60-90 years and in centenarians | Seripa et al., 2006 | Entrez Gene Ensembl HapMap |
| APOE | Apolipoprotein E | 19q13.31 | Greek | The prevalence of genotypes in 80 healthy aged individuals (>80 years) and 391 adults (median age 43 years) was examined | Genotypes were comparable in both groups with the exception of E3/3 and E3/4, which were significantly higher and lower, respectively, in aged individuals. The epsilon2 and epsilon3 allele frequencies were not different between the groups. The epsilon4 allele was significantly less frequent in aged individuals compared to controls. | Stakias et al., 2007 | Entrez Gene Ensembl HapMap |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 17p11.2 | European-American | Male (n= 4766) and female (n = 6202) divided into young (1839 years) and old (60 years) groups were examined for polymorphisms | A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females. | Kammerer et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| BF | B-factor, properdin | Italian | Alleles were examined in healthy aged people (77 centenarians and 89 elderly subjects) | The frequencies of the alleles were similar in the studied cohorts | Bellavia et al., 1999 | Ensembl HapMap |
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| BRCA1 | Breast cancer 1, early onset | 17q21.31 | New England Caucasians and Italian | Polymorphisms were examined in 102 centenarians from the New England area and 84 centenarians from Italy. The control population consisted of 97 individuals from Italy. | The genotype "a+a" was more frequent in both centenarian groups compared to the control group whereas the genotype "a+b" was less frequent. The results, however, were not statistically significant. | Vijg et al., 2000 | Entrez Gene UniGene Ensembl HapMap |
| C3 | Complement component 3 | 19p13.3 | Italian | C3 alleles were examined in healthy aged people (77 centenarians and 89 elderly subjects) | The frequencies of C3 alleles were similar in the studied cohorts | Bellavia et al., 1999 | Entrez Gene UniGene Ensembl HapMap |
| C4 | Complement component 4 | Italian | C4 alleles were examined in healthy aged people (77 centenarians and 89 elderly subjects) | The frequencies of C4A alleles were similar in the studied cohorts. For C4B null allele (C4BQ0) a trend toward an increase in the older cohort was observed, although the differences were not significant after statistical correction. | Bellavia et al., 1999 | Ensembl HapMap |
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| CAT | Catalase | 11p13 | Danish | The -262C/T polymorphism was examined in 2223 Danish individuals aged 45-93 years | The -262C/T polymorphism was not associated with survival | Christiansen et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| CPB2 | Carboxypeptidase B2 (plasma, carboxypeptidase U) | 13q14.13 | American Caucasian | Genotypes were studied in 2224 men and women aged 65 or older at baseline | During 10 years of follow-up, men with the -438 A/A genotype had decreased mortality due to all causes, and lived, on average, longer than men with the -438 G allele. The effects of -438 G/A in women were smaller and not statistically significant. | Reiner et al., 2005 | Entrez Gene Ensembl HapMap |
| CETP | Cholesteryl ester transfer protein | 16q13 | Ashkenazi Jews | The I405V polymorphism distribution was examined in 213 Ashkenazi Jews with exceptional longevity (mean [SD] age, 98.2 [5.3] years), their offspring (n = 216; mean [SD] age, 68.3 [6.7] years) and in an age-matched control group of Ashkenazi Jews (n = 258) + participants from the Framingham Offspring Study (n = 589) | Probands with exceptional longevity showed an increased frequency of homozygosity for the 405 valine allele of (VV genotype) compared with controls | Barzilai et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| CETP | Cholesteryl ester transfer protein | 16q13 | Japanese | Polymorphisms (mutations in intron 14 and exon 15, and Taq1B) were examined in 256 centenarians and 190 healthy younger controls (22-65 years old) | The allelic frequencies did not differ between the two groups | Arai et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| CETP | Cholesteryl ester transfer protein | 16q13 | Italian | The I405V polymorphism was examined in 175 Italian centenarians and, as a control group, 189 sex-matched healthy individuals | No association with longevity was found | Cellini et al., 2005 | Entrez Gene UniGene Ensembl HapMap |
| CNDP1 | Carnosine dipeptidase 1 (metallopeptidase M20 family) | 18q22.3 | German | The frequency of CNDP1 alleles in German centenarians (n=330), patients with premature coronary heart disease, and matched controls was examined. A total of 1382 individuals were examined. | There was no difference in allele or genotype frequency between centenarians and their control group, or between cardiovascular patients and their control group | Zschocke et al., 2006 | Entrez Gene Ensembl HapMap |
| CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 15q24.1 | Northern Italian | SNP was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age | No association with longevity was found | Taioli et al., 2001 | Entrez Gene Ensembl HapMap |
| CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 15q24.1 | German, Bonn | T461N and 3801 T/ C SNPs were examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years | No association with longevity was found | Pesch et al., 2004 | Entrez Gene Ensembl HapMap |
| CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 2p22.2 | German, Bonn | V432L SNP was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years | In octogenarians, the 432L allele was less prevalent than in the reference group | Pesch et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| CYP2E1 | Cytochrome P450, family 2, subfamily E, polypeptide 1 | 10q26.3 | Spanish | The enzymatic polymorphism was examined in 41 nonagenarians (10 males, mean age 92.2 years, range 90-98) free of known malignancies or neurodegenerative diseases and in control groups comprised of 137 (116 males, mean age 32 years) | No association with longevity was found | Agundez et al., 1997 | Entrez Gene UniGene Ensembl HapMap |
| CYP2D6 | Cytochrome P450, family 2, subfamily D, polypeptide 6 | Spanish | The enzymatic polymorphism was examined in 41 nonagenarians (10 males, mean age 92.2 years, range 90-98) free of known malignancies or neurodegenerative diseases and in control groups comprised of 217 healthy volunteers (128 males, mean age 36.3 years) | No association with longevity was found | Agundez et al., 1997 | Ensembl HapMap |
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| CYP2D6 | Cytochrome P450, family 2, subfamily D, polypeptide 6 | French | CYP2D63 (A2637 deletion) and CYP2D64 (G1934A transition) alleles were examined in 552 centenarians and 243 controls aged 20-70 years | No significant difference was found between centenarian and control subjects | Muiras et al., 1998 | Ensembl HapMap |
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| F2 | Coagulation factor II (thrombin) | 11p11.2 | Danish | F2 20210 G/A SNP was examined in 187 centenarians and 201 controls (20-64 years) | No association with longevity was found | Bladbjerg et al., 1999 | Entrez Gene Ensembl HapMap |
| F2 | Coagulation factor II (thrombin) | 11p11.2 | Danish | F2 20210 G/A SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | No association with longevity was found | Tan et al., 2001 | Entrez Gene Ensembl HapMap |
| F2 | Coagulation factor II (thrombin) | 11p11.2 | American Caucasians | F2 20210 G/A SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females) | No statistically significant decrease in genotype or allele frequency was observed among carriers of F2 | Hessner et al., 2001 | Entrez Gene Ensembl HapMap |
| F5 | Coagulation factor V (proaccelerin, labile factor) | 1q24.2 | American Caucasian | G1691A SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females) | No statistically significant decrease in genotype or allele frequency was observed among carriers of F5 | Hessner et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| F7 | Coagulation factor VII (serum prothrombin conversion accelerator) | 13q34 | Italian | The R353Q substitution polymorphism in exon 8 was examined in 124 healthy individuals over 100 years of age and 130 young, healthy individuals | No significant differences relative to longevity were found | Mannucci et al., 1997 | Entrez Gene UniGene Ensembl HapMap |
| F7 | Coagulation factor VII (serum prothrombin conversion accelerator) | 13q34 | Danish | The R353Q substitution, intron 7 (37bp)n, and -323ins10 polymorphisms were examined in 187 centenarians and 201 healthy controls, aged 20-64 years (mean age 42 years). | The genotype frequencies in the centenarians and in the controls were similar | Bladbjerg et al., 1999 | Entrez Gene UniGene Ensembl HapMap |
| F7 | Coagulation factor VII (serum prothrombin conversion accelerator) | 13q34 | Danish | Blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10 SNPs were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | R/Q353 and FVII-323ins10 manifest significant influences on survival in males, with reduced hazards of death for carriers of the Q353 allele and the FVII-323P10 allele | Tan et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| F7 | Coagulation factor VII (serum prothrombin conversion accelerator) | 13q34 | Danish | Polymorphisms were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | No association with longevity was found | Tan et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| F7 | Coagulation factor VII (serum prothrombin conversion accelerator) | 13q34 | Ashkenazi Jews, Jerusalem | Arg/Gln R353Q SNP was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years) | There was a decrease in the percentage of the A allele in older Ashkenazi male subjects and a corresponding marked decrease (9.72.1%) in the percentage of AA homozygotes | Stessman et al., 2005 | Entrez Gene UniGene Ensembl HapMap |
| FAS | Fas (TNF receptor superfamily, member 6) | 10q23.31 | Northern Italian | The -670 and -1377 position SNPs were examined in 50 centenarians and 86 young controls | Genotype and allele distribution for both polymorphisms were similar in controls and centenarians | Pinti et al., 2002 | Entrez Gene UniGene Ensembl HapMap |
| FASLG | Fas ligand (TNF superfamily, member 6) | 1q25.1 | Northern Italian | The -124 and 169 position SNPs were examined in 50 centenarians and 86 young controls | Genotype and allele distribution for both polymorphisms were similar in controls and centenarians | Pinti et al., 2002 | Entrez Gene UniGene Ensembl HapMap |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 1q23.3 | German | The FCGR2A-His131Arg polymorphism was analyzed in a group of 408 German centenarians and two samples of younger Germans aged 60-75 and 18-49 years | No statistically significant differences were observed between the three age groups | Flesch et al., 2006 | Entrez Gene Ensembl HapMap |
| FGB | Fibrinogen beta chain | Italian | The G/A-455 SNP was examined in 124 healthy individuals over 100 years old and 130 young, healthy individuals | Alleles and genotypes were found with similar frequencies in centenarians and in the control group | Mannucci et al., 1997 | Ensembl HapMap |
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| FGB | Fibrinogen beta chain | Danish | The -455G/A SNP was examined in 187 centenarians and 201 healthy controls aged 20-64 years (mean age 42 years) | The genotype frequencies in the centenarians and the controls were similar | Bladbjerg et al., 1999 | Ensembl HapMap |
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| FGB | Fibrinogen beta chain | Danish | The G/A-455 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | No association with longevity was found | Tan et al., 2001 | Ensembl HapMap |
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| FGB | Fibrinogen beta chain | American Caucasian | Genotypes for -455 G/A were studied in 2224 men and women aged 65 years and older at baseline | During 10 years of follow-up, no association with survival was found | Reiner et al., 2005 | Ensembl HapMap |
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| FOXO1A | Forkhead box O1A (rhabdomyosarcoma) | 13q14.11 | Italian | The (T/C, 97347 bp) polymorphism was examined in healthy people 1785 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females | No significant differences relative to longevity were found | Bonafe et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| FOXO1A | Forkhead box O1A (rhabdomyosarcoma) | 13q14.11 | Japanese | 3 intronic polymorphisms were examined in 122 Japanese semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33) | No significant differences relative to longevity were found | Kojima et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| GH1 | Growth hormone 1 | 17q23.3 | Dutch, Leiden | Intron 4 A/T SNP was examined in 1576 individuals aged 85 and older | Female carriers of the A allele had reduced height and mortality | Heemst et al., 2005 | Entrez Gene Ensembl HapMap |
| GHRHR | Growth hormone releasing hormone receptor | 7p14.3 | Dutch, Leiden | Codon 57 A/G SNP was examined in 1576 individuals aged 85 and older | No association with longevity was found | Heemst et al., 2005 | Entrez Gene Ensembl HapMap |
| GP1BA | Glycoprotein Ib (platelet), alpha polypeptide | 17p13.2 | Danish | The L/P codon 33 SNP was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) | No association with longevity was found | Pesch et al., 2004 | Entrez Gene Ensembl HapMap |
| GSTM1 | Glutathione S-transferase M1 | 1p13.3 | French | The GSTM1 deletion was examined in 552 centenarians and 243 controls aged 20-70 years | No significant difference was found between centenarian and control subjects | Muiras et al., 1998 | Entrez Gene UniGene Ensembl HapMap |
| GSTM1 | Glutathione S-transferase M1 | 1p13.3 | Northern Italian | GSTM1 deletion was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age | No association with longevity was found | Taioli et al., 2001 | Entrez Gene UniGene Ensembl HapMap |
| GSTM1 | Glutathione S-transferase M1 | 1p13.3 | German, Bonn | GSTM1 deletion was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years | Octogenarians turned out to have a marginally significant more GSTM1 negatives | Pesch et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| GSTM1 | Glutathione S-transferase M1 | 1p13.3 | Danish | The GSTM1 deletion polymorphism was examined in a longitudinal study of 681 elderly Danish twins (234 men and 447 women) | A non-significant trend for carriage of two copies of the GSTM1 functional gene was found | Christiansen et al., 2006 | Entrez Gene UniGene Ensembl HapMap |
| GSTP1 | Gutathione S-transferase pi | 11q13.2 | German, Bonn | I105V SNP was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years | There were fewer observed heterozygous 105IV genotypes and more homozygous 105VV genotypes than expected among octogenarians | Pesch et al., 2004 | Entrez Gene Ensembl HapMap |
| GSTT1 | Glutathione S-transferase theta 1 | 22q11.23 | Northern Italian | Deletion was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age | A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects | Taioli et al., 2001 | Entrez Gene Ensembl HapMap |
| GSTT1 | Glutathione S-transferase theta 1 | 22q11.23 | German, Bonn | Deletion was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years | Octogenarians had less GSTT1 deficient genotypes | Pesch et al., 2004 | Entrez Gene Ensembl HapMap |
| GSTT1 | Glutathione S-transferase theta 1 | 22q11.23 | Danish | Deletion polymorphism was examined in a longitudinal study of 681 elderly Danish twins (234 men and 447 women) | Both heterozygosity and homozygosity for the GSTT1 functional gene was associated with a moderate but significant increased mortality in women | Christiansen et al., 2006 | Entrez Gene Ensembl HapMap |
| HFE | Hemochromatosis | 6p22.2 | Sicilian | C282Y, H63D and S65C polymorphisms were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women) | A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people. | Lio et al., 2002 | Entrez Gene UniGene Ensembl HapMap |
| HFE | Hemochromatosis | 6p22.2 | Sardinian | The C282Y, H63D and S65C SNPs were examined in 61 controls and 57 centenarians | Although there was a trend for an increased frequency of the H63D allele in centenarian women, no significant differences were observed in frequencies of the different alleles between young and centenarians | Carru et al., 2003 | Entrez Gene UniGene Ensembl HapMap |
| HLA-A1 | Major histocompatibility complex, class I, A1 | Irish, Belfast | 100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined | No age-related allele or genotype frequencies were observed | Ross et al., 2003 | Ensembl HapMap |
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| HLA-A1 | Major histocompatibility complex, class I, A1 | Bulgarian | 12 alleles were examined in 17 unrelated elderly (age 6590 years; 6 males and 11 females), 23 family members (age 1857 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 2553 years (40 male and 65 female) | The most frequent HLA alleles in elderly Bulgarians were A01 and A02. A number of haplotypes were also found to be more frequent in elderly Bulgarians compared to the controls. | Naumova et al., 2004 | Ensembl HapMap |
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| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | Japanese, Okinawa | Polymorphisms in Okinawan centenarians were analyzed | DRB1*1401 allele was significantly increased in the centenarians while DRB1*0101 and DRB1*1201 alleles were slightly decreased | Akisaka et al., 1997 | Ensembl HapMap |
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| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | French | The longevous groups included two independent cohorts totalling 533 centenarians and 163 nonagenarian siblings. Control group included 2950 subjects. | DR7 frequency was elevated in longevous men and DR13 frequency was increased in centenarians. DR11's influence on longevity displayed a significant interaction with sex, with an increase in women from longevous sibships. HLA-DR homozygotes were more frequent in centenarians than in controls. | Ivanova et al., 1998 | Ensembl HapMap |
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| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | Bulgarian | 10 alleles were examined in 17 unrelated elderly (age 6590 years; 6 males and 11 females), 23 family members (age 1857 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 2553 years (40 male and 65 female) | The most frequent HLADRB1 alleles in elderly Bulgarians were DRB111 and DRB113. The most frequent haplotypes in elderly Bulgarians compared to the controls were DRB111DQB103 and DRB113DQB106. | Naumova et al., 2004 | Ensembl HapMap |
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| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | Mexican | A total of 71 healthy elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 54 years; mean 35.2 years) healthy individuals unrelated to elders. | A significant increased frequency of HLA-DRB1*11 was found in elderly women whereas this allele was not present in elderly males | Soto-Vega et al., 2005 | Ensembl HapMap |
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| HLA-DRB3 | Major histocompatibility complex, class II, DR beta 3 | Irish, Belfast | 100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined | No age-related allele or genotype frequencies were observed | Ross et al., 2003 | Ensembl HapMap |
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| HLA-DRB5 | Major histocompatibility complex, class II, DR beta 5 | Dutch, Leiden | 964 inhabitants aged 85 years and over and 2444 young controls, aged 20-35 years, with an identical ethnic and demographic background were examined | HLA-DR5 was higher in the group of 85 years and over, as compared to the control group | Lagaay et al., 1991 | Ensembl HapMap |
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| HLA-DQA1 | Major histocompatibility complex, class II, DQ alpha 1 | Japanese, Okinawa | Polymorphisms in HLA class II alleles of Okinawan centenarians were analyzed | DQA10101=0104 and DQA105 alleles were significantly increased in the centenarians | Akisaka et al., 1997 | Ensembl HapMap |
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| HLA-DQA1 | Major histocompatibility complex, class II, DQ alpha 1 | Mexican | A total of 71 healthy elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 54 years; mean 35.2 years) healthy individuals unrelated to elders. | The frequencies of the alleles tested were not statistically different among groups | Soto-Vega et al., 2005 | Ensembl HapMap |
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| HLA-DQA1 | Major histocompatibility complex, class II, DQ alpha 1 | Sardinian | 129 centenarians and 154 sexagenarians randomly selected from the inhabitants of the same province were examined. In addition, 24 85-year-old sibs of centenarians were enrolled. | Sib pair analysis showed nonsignificant differences between the observed and expected percentage of DQA* allele sharing | Scola et al., 2006 | Ensembl HapMap |
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| HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | Japanese, Okinawa | Polymorphisms in HLA class II alleles of Okinawan centenarians were analyzed | DQB105 and DQB103 alleles were significantly increased in the centenarians | Akisaka et al., 1997 | Ensembl HapMap |
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| HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | Bulgarian | 5 alleles were examined in 17 unrelated elderly (age 6590 years; 6 males and 11 females), 23 family members (age 1857 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 2553 years (40 male and 65 female) | The most frequent DQB1 alleles in elderly Bulgarians were DQB103 and DQB105 | Naumova et al., 2004 | Ensembl HapMap |
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| HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | Sardinian | 129 centenarians and 154 sexagenarians randomly selected from the inhabitants of the same province were examined. In addition, 24 85-year-old sibs of centenarians were enrolled. | Sib pair analysis showed nonsignificant differences between the observed and expected percentage of DQB1* allele sharing. | Scola et al., 2006 | Ensembl HapMap |
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| HLA-B | Major histocompatibility complex, class I, B | Dutch, Leiden | 964 inhabitants aged 85 years and over and 2444 young controls, aged 20-35 years, with an identical ethnic and demographic background were examined | HLA-B40 was lower in the group of 85 years and over, as compared to the control group | Lagaay et al., 1991 | Ensembl HapMap |
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| HLA-B | Major histocompatibility complex, class I, B | 6p21.33 | Irish, Belfast | 100 control samples (59% female, 41% male with an age-range of 19-45 years old) and 93 aged samples (70% female, 30% male with an age-range of 80-97 years old) were examined | No age-related allele or genotype frequencies were observed | Ross et al., 2003 | Entrez Gene Ensembl HapMap |
| HLA-B | Major histocompatibility complex, class I, B | 6p21.33 | Bulgarian | 14 alleles were examined in 17 unrelated elderly (age 6590 years; 6 males and 11 females), 23 family members (age 1857 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 2553 years (40 male and 65 female) | The most frequent HLB alleles in elderly Bulgarians were B18 and B*51 | Naumova et al., 2004 | Entrez Gene Ensembl HapMap |
| HLA-B | Major histocompatibility complex, class I, B | 6p21.33 | Mexican | 71 healthy elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 54 years; mean 35.2 years) healthy individuals unrelated to elders. | The frequencies of the alleles tested were not statistically different among groups | Soto-Vega et al., 2005 | Entrez Gene Ensembl HapMap |
| HLA-C | Major histocompatibility complex, class I, C | 6p21.33 | Bulgarian | 10 alleles were examined in 17 unrelated elderly (age 6590 years; 6 males and 11 females), 23 family members (age 1857 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 2553 years (40 male and 65 female) | The most frequent HLC alleles in elderly Bulgarians were C*07 and C*04 | Naumova et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| HMOX1 | Heme oxygenase (decycling) 1 | 22q12.3 | Japanese | A (GT)n repeat polymorphism in the promoter region of the human HO-1 gene was examined in younger (60 years, 59 male and 45 female) and older (60-75 years, 95 male and 106 female) subjects | The proportion of allelic frequencies in class L with a large size of (GT)n repeat, as well as the genotypic frequencies in group I with class L alleles, was significantly lower in the oldest male subjects than in the younger males. In contrast, in the oldest female subjects this was not observed. | Yamaya et al., 2003 | Entrez Gene Ensembl HapMap |
| HSPA1A | Heat shock 70kDa protein 1A | Southern Italian | (A/C)-110 polymorphism was examined in 591 subjects (263 males and 328 females; age range 18109 years; 36 male and 84 female centenarians) | A significant age-related decrease of the frequency of allele (A)-110 was observed in females, while no difference was observed in the males | Altomare et al., 2003 | Ensembl HapMap |
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| HSPA1A | Heat shock 70kDa protein 1A | Danish | The -110A/C polymorphism was examined in a cohort of aged Danish twins (individuals aged between 70 and 91 years, categorized according to the presence or absence of various diseases) | An association was found between low self-rated health and heterozygosity (AC genotype) | Singh et al., 2004 | Ensembl HapMap |
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| HSPA1A | Heat shock 70kDa protein 1A | Ashkenazi Jews | rs1043618 polymorphism was examined in 347 centenarians, 260 centenarian offspring, and 238 controls | No genetic associations were found with two SNPs within two hsp70 genes | Terry et al., 2006 | Ensembl HapMap |
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| HSPA1A | Heat shock 70kDa protein 1A | Danish | The A/C -110 polymorphism was examined in 426 participants of various ages | Female carriers of CC genotype survive better than the noncarriers (AA and AC) | Singh et al., 2006 | Ensembl HapMap |
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| HSPA1B | Heat shock 70kDa protein 1B | Danish | The A/G (1267 coding) polymorphism was examined in 426 participants of various ages | Female carriers of GG genotype survive better than noncarriers | Singh et al., 2006 | Ensembl HapMap |
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| HSPA1B | Heat shock 70kDa protein 1B | Ashkenazi Jews | rs6457452 polymorphism was examined in 347 centenarians, 260 centenarian offspring, and 238 controls | No genetic associations were found | Terry et al., 2006 | Ensembl HapMap |
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| HSPA1L | Heat shock 70kDa protein 1-like | Irish | The frequency of the T2437C transversion (Met to Thr) polymorphism was investigated in a healthy aged population of 100 control samples (59% female, 41% male with an age-range of 1945 years) and 129 aged consecutive samples (70% female, 30% male with an age range of 8097 years) | The 2437T polymorphic nucleotide was observed to increase in the elderly, although not attaining statistical significance. The TT genotype was observed to be significantly increased within the aged population, while conversely the TC genotype was significantly decreased in the aged subjects. | Ross et al., 2003 | Ensembl HapMap |
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| HSPA1L | Heat shock 70kDa protein 1-like | Danish | The T/C (2437 coding) polymorphism was examined in a cohort of aged Danish twins (individuals aged between 70 and 91 years, categorized according to the presence or absence of various diseases) | No association with longevity was found | Singh et al., 2004 | Ensembl HapMap |
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| IFNG | Interferon gamma | 12q15 | Italian | The distribution of 874T/A polymorphism was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men) | The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls. | Lio et al., 2002 | Entrez Gene UniGene Ensembl HapMap |
| IFNG | Interferon gamma | 12q15 | Sardinian | 112 (36 male, 76 female) centenarians, as well as 137 sixty-year-old controls, were analyzed for 874T/A SNP | No significant differences were observed in centenarians and controls | Pes et al., 2004 | Entrez Gene UniGene Ensembl HapMap |
| IFNG | Interferon gamma | 12q15 | Irish | 100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for Intron I microsatellite repeats | No significant differences were observed in centenarians and controls | Ross et al., 2003 |