Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: sams-1

Gene Information (Entrez Gene ID: 181370)

Symbol
sams-1
Name
S-Adenosyl Methionine Synthetase 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181370

Potential relevance to dietary restriction and ageing

Observations

sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [2240].

References

    In other databases

    GenAge model organism genes
    • This gene is present as sams-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as SAM1
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Mat1a

    Homologs

    Danio rerio
    mat2al
    Danio rerio
    mat2ab
    Danio rerio
    mat1a
    Danio rerio
    mat2aa
    Drosophila melanogaster
    Sam-S
    Homo sapiens
    MAT1A
    Mus musculus
    Mat2a
    Mus musculus
    Mat1a
    Rattus norvegicus
    Mat1a
    Saccharomyces cerevisiae
    SAM1
    Schizosaccharomyces pombe
    sam1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181370
    Homologues
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    UniProt
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    Internet
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