GenDR Dietary Restriction Gene Manipulation: Npy
Gene Information (Entrez Gene ID: 109648)
- neuropeptide Y
- Mus musculus (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
While dietary restriction extends median lifespan of wild-type mice by 20.3% and 36%, in males and females respectively, Npy-/-median lifespan is 1.9% shorter for males and 1% shorter for females upon dietary restriction. At a 25th percentile survival point, Npy-/- mice lived 7.1% and 19.5% longer on dietary restriction than controls, overall displaying a diminished effect of DR in the absence of Npy. In addition, the effect of dietary restriction on the occurrence of spontaneous tumors and oxidative stress responses was attenuated in Npy-null in comparison to wild-type mice. Contrastly, physiological processes activated during adaptation to DR (including inhibition of insulin/IGF-1, modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation), in the Npy knockout mice, are similar to those that occur in the wild-type mice.