LongevityMap Gene
Gene details
- HGNC symbol
- NOS3
- Aliases
- eNOS; ECNOS
- Common name
- nitric oxide synthase 3
- Description
- Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- Cytogenetic Location
- 7q36.1
- UCSC Genome Browser
- View 7q36.1 on the UCSC genome browser
- OMIM
- 163729
- Ensembl
- ENSG00000164867
- UniProt/Swiss-Prot
- A0A0A0MTA6_HUMAN
- Entrez Gene
- 4846
- UniGene
- 647092
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Nos3
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- The variability of the three human genes (NOS1, NOS2, NOS3) was studied in a large sample (763 subjects, age range 19–107 years, median age 81 years). The sample analyzed included 417 females and 346 males.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1879417, showed a significant association with the longevity phenotype. The NOS2 rs2297518 SNP was only marginally associated with longevity.
- Indentifier
- rs10277237
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs12703107
- Reference