LongevityMap Gene

Gene details

HGNC symbol: IL12A
Aliases: P35; CLMF; NFSK; NKSF1; IL-12A
Common name: interleukin 12A
Description: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 3q25.33
UCSC Genome Browser: View 3q25.33 on the UCSC genome browser
OMIM: 161560
Ensembl: ENSG00000168811
UniProt/Swiss-Prot: IL12A_HUMAN
Entrez Gene: 3592
UniGene: 673
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/1

Longevity Association

Non-significant

Population

Irish

Study Design

Conclusions

Indentifier

IL12A

Reference

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions: 281 SNPs were found to discriminate between cases and controls
Indentifier