LongevityMap variant group

1.

Identifier: rs1189843
Cytogenetic Location

2.

Identifier: rs2304965
Cytogenetic Location

3.

Identifier: rs12353067
Cytogenetic Location

4.

Identifier: rs12621193
Cytogenetic Location

5.

Identifier: rs2722222
Cytogenetic Location

6.

Identifier: rs4497194
Cytogenetic Location

7.

Identifier: rs9378384
Cytogenetic Location

8.

Identifier: rs2660342
Cytogenetic Location

9.

Identifier: rs8073559
Cytogenetic Location

10.

Identifier: rs1550765
Cytogenetic Location

11.

Identifier: rs2331101
Cytogenetic Location

12.

Identifier: rs346119
Cytogenetic Location

13.

Identifier: rs6946852
Cytogenetic Location

14.

Identifier: rs2543356
Cytogenetic Location

15.

Identifier: rs1581035
Cytogenetic Location

16.

Identifier: rs12043001
Cytogenetic Location

17.

Identifier: rs11943045
Cytogenetic Location

18.

Identifier: rs13125710
Cytogenetic Location

19.

Identifier: rs1490813
Cytogenetic Location

20.

Identifier: rs8003056
Cytogenetic Location

21.

Identifier: rs7677714
Cytogenetic Location

22.

Identifier: rs2553377
Cytogenetic Location

23.

Identifier: rs9324976
Cytogenetic Location

24.

Identifier: rs10229977
Cytogenetic Location

25.

Identifier: rs1812736
Cytogenetic Location

26.

Identifier: rs7505612
Cytogenetic Location

27.

Identifier: rs2660885
Cytogenetic Location

28.

Identifier: rs1322048
Cytogenetic Location

29.

Identifier: rs8069437
Cytogenetic Location

30.

Identifier: rs1674159
Cytogenetic Location

31.

Identifier: rs11601702
Cytogenetic Location

32.

Identifier: rs2247549
Cytogenetic Location

33.

Identifier: rs975072
Cytogenetic Location

34.

Identifier: rs9899404
Cytogenetic Location

35.

Identifier: rs1340573
Cytogenetic Location

36.

Identifier: rs147295
Cytogenetic Location

37.

Identifier: rs6580511
Cytogenetic Location

38.

Identifier: rs1411552
Cytogenetic Location

39.

Identifier: rs10489436
Cytogenetic Location

40.

Identifier: rs4722094
Cytogenetic Location

41.

Identifier: rs4285687
Cytogenetic Location

42.

Identifier: rs12446827
Cytogenetic Location

43.

Identifier: rs10890985
Cytogenetic Location

44.

Identifier: rs2738173
Cytogenetic Location

45.

Identifier: rs2745252
Cytogenetic Location

46.

Identifier: rs1016013
Cytogenetic Location

47.

Identifier: rs829751
Cytogenetic Location

48.

Identifier: rs2334207
Cytogenetic Location

49.

Identifier: rs1568282
Cytogenetic Location

50.

Identifier: rs4245543
Cytogenetic Location

51.

Identifier: rs9513192
Cytogenetic Location

52.

Identifier: rs7155817
Cytogenetic Location

53.

Identifier: rs899430
Cytogenetic Location

54.

Identifier: rs1505696
Cytogenetic Location

55.

Identifier: rs4461634
Cytogenetic Location

56.

Identifier: rs1002098
Cytogenetic Location

57.

Identifier: rs11063009
Cytogenetic Location

58.

Identifier: rs1834461
Cytogenetic Location

59.

Identifier: rs4933309
Cytogenetic Location

60.

Identifier: rs1470196
Cytogenetic Location

61.

Identifier: rs452707
Cytogenetic Location

62.

Identifier: rs9308765
Cytogenetic Location

63.

Identifier: rs1858897
Cytogenetic Location

64.

Identifier: rs767478
Cytogenetic Location

65.

Identifier: rs828154
Cytogenetic Location

66.

Identifier: rs2866705
Cytogenetic Location

67.

Identifier: rs277432
Cytogenetic Location

68.

Identifier: rs303542
Cytogenetic Location

69.

Identifier: rs8018467
Cytogenetic Location

70.

Identifier: rs2660888
Cytogenetic Location

71.

Identifier: rs4141153
Cytogenetic Location

72.

Identifier: rs2253363
Cytogenetic Location

73.

Identifier: rs514217
Cytogenetic Location

74.

Identifier: rs11687681
Cytogenetic Location

75.

Identifier: rs2880540
Cytogenetic Location

76.

Identifier: rs11610554
Cytogenetic Location

77.

Identifier: rs1368774
Cytogenetic Location

78.

Identifier: rs751481
Cytogenetic Location

79.

Identifier: rs10923673
Cytogenetic Location

80.

Identifier: rs3904864
Cytogenetic Location

81.

Identifier: rs9652250
Cytogenetic Location

82.

Identifier: rs855137
Cytogenetic Location

83.

Identifier: rs10505561
Cytogenetic Location

84.

Identifier: rs1998536
Cytogenetic Location

85.

Identifier: rs8098316
Cytogenetic Location

86.

Identifier: rs1525501
Cytogenetic Location

87.

Identifier: rs2679234
Cytogenetic Location

88.

Identifier: rs2014547
Cytogenetic Location

89.

Identifier: rs401974
Cytogenetic Location

90.

Identifier: rs2927261
Cytogenetic Location

91.

Identifier: rs4771711
Cytogenetic Location

92.

Identifier: rs12129750
Cytogenetic Location

93.

Identifier: rs10863373
Cytogenetic Location

94.

Identifier: rs2604294
Cytogenetic Location

95.

Identifier: rs10263457
Cytogenetic Location

96.

Identifier: rs8080728
Cytogenetic Location

97.

Identifier: rs158807
Cytogenetic Location

98.

Identifier: rs10498342
Cytogenetic Location

99.

Identifier: rs1230155
Cytogenetic Location

100.

Identifier: rs12489296
Cytogenetic Location

101.

Identifier: rs12606250
Cytogenetic Location

102.

Identifier: rs1822590
Cytogenetic Location

103.

Identifier: rs12121466
Cytogenetic Location

104.

Identifier: rs924584
Cytogenetic Location

105.

Identifier: rs567971
Cytogenetic Location

106.

Identifier: rs2901840
Cytogenetic Location

107.

Identifier: rs11189119
Cytogenetic Location

1.

Identifier: rs3780223
Cytogenetic Location: 9p22.2-p22.1
UCSC Genome Browser: View 9p22.2-p22.1 on the UCSC genome browser

Gene details

HGNC symbol: ADAMTSL1
Aliases: C9orf94; PUNCTIN; ADAMTSR1; ADAMTSL-1
Common name: ADAMTS like 1
Description: This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
OMIM: 609198
Ensembl: ENSG00000178031
UniProt/Swiss-Prot: ATL1_HUMAN
Entrez Gene: 92949
UniGene: 741483
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: madd-4
Drosophila melanogaster: CG31619
Mus musculus: Adamtsl1
Rattus norvegicus: Adamtsl1

1.

Identifier: rs2269475
Cytogenetic Location: 6p21.33
UCSC Genome Browser: View 6p21.33 on the UCSC genome browser

Gene details

HGNC symbol: AIF1
Aliases: IBA1; IRT1; AIF-1; IRT-1
Common name: allograft inflammatory factor 1
Description: This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
OMIM: 601833
Ensembl: ENSG00000204472
UniProt/Swiss-Prot: AIF1_HUMAN
Entrez Gene: 199
UniGene: 76364
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Aif1
Rattus norvegicus: Aif1

In other databases

GenAge microarray genes

This gene is present as AIF1

1.

Identifier: rs2075773
Cytogenetic Location: 14q24.3
UCSC Genome Browser: View 14q24.3 on the UCSC genome browser

2.

Identifier: rs1076584
Cytogenetic Location: 14q24.3
UCSC Genome Browser: View 14q24.3 on the UCSC genome browser

Gene details

HGNC symbol: ANGEL1
Aliases: Ccr4e; KIAA0759
Common name: angel homolog 1
Description
Other longevity studies of this gene: 1
OMIM
Ensembl: ENSG00000013523
UniProt/Swiss-Prot: A0A024R6B2_HUMAN
Entrez Gene: 23357
UniGene: 497448
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: angl-1
Danio rerio: angel1
Drosophila melanogaster: angel
Mus musculus: Angel1
Rattus norvegicus: Angel1
Saccharomyces cerevisiae: CCR4

1.

Identifier: rs765850
Cytogenetic Location: 4p14-p13
UCSC Genome Browser: View 4p14-p13 on the UCSC genome browser

Gene details

HGNC symbol: APBB2
Aliases: FE65L; FE65L1
Common name: amyloid beta precursor protein binding family B member 2
Description: The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
OMIM: 602710
Ensembl: ENSG00000163697
UniProt/Swiss-Prot: APBB2_HUMAN
Entrez Gene: 323
UniGene: 479602
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: feh-1
Danio rerio: apbb2b
Danio rerio: CABZ01085924.1
Mus musculus: Apbb2
Rattus norvegicus: Apbb2

1.

Identifier: rs7207422
Cytogenetic Location: 17q11.2-q12
UCSC Genome Browser: View 17q11.2-q12 on the UCSC genome browser

Gene details

HGNC symbol: ASIC2
Aliases: ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1
Common name: acid sensing ion channel subunit 2
Description: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Other longevity studies of this gene: 3
OMIM: 601784
Ensembl: ENSG00000108684
UniProt/Swiss-Prot: ASIC2_HUMAN
Entrez Gene: 40
UniGene: 368417
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: acd-1
Caenorhabditis elegans: delm-1
Caenorhabditis elegans: acd-4
Caenorhabditis elegans: acd-5
Caenorhabditis elegans: delm-2
Caenorhabditis elegans: flr-1
Caenorhabditis elegans: acd-2
Danio rerio: BX663610.1
Mus musculus: Asic2
Rattus norvegicus: Asic2

1.

Identifier: rs1389488
Cytogenetic Location: 12q21.1
UCSC Genome Browser: View 12q21.1 on the UCSC genome browser

Gene details

HGNC symbol: ATXN7L3B
Aliases: lnc-SCA7
Common name: ataxin 7 like 3B
Description
OMIM: 615579
Ensembl: ENSG00000253719
UniProt/Swiss-Prot: A7L3B_HUMAN
Entrez Gene: 552889
UniGene: 744849
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: si:dkeyp-118b1.2
Drosophila melanogaster: Sgf11
Mus musculus: Atxn7l3b
Rattus norvegicus: Atxn7l3b

1.

Identifier: rs6732163
Cytogenetic Location: 2p23.2
UCSC Genome Browser: View 2p23.2 on the UCSC genome browser

Gene details

HGNC symbol: BABAM2
Aliases: BRE; BRCC4; BRCC45
Common name: BRISC and BRCA1 A complex member 2
Description: This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]
OMIM: 610497
Ensembl: ENSG00000158019
UniProt/Swiss-Prot: BRE_HUMAN
Entrez Gene: 9577
UniGene: 258314
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: bre
Mus musculus: Bre
Rattus norvegicus: Bre

1.

Identifier: rs7959761
Cytogenetic Location: 12p12.1
UCSC Genome Browser: View 12p12.1 on the UCSC genome browser

Gene details

HGNC symbol: BHLHE41
Aliases: DEC2; hDEC2; BHLHB3; SHARP1
Common name: basic helix-loop-helix family member e41
Description: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]
OMIM: 606200
Ensembl: ENSG00000123095
UniProt/Swiss-Prot: A0A024RAV8_HUMAN
Entrez Gene: 79365
UniGene: 177841
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: bhlhe41
Mus musculus: Bhlhe41
Rattus norvegicus: Bhlhe41

1.

Identifier: rs11211037
Cytogenetic Location: 1p34.1
UCSC Genome Browser: View 1p34.1 on the UCSC genome browser

Gene details

HGNC symbol: BTBD19
Aliases
Common name: BTB domain containing 19
Description
OMIM
Ensembl: ENSG00000222009
UniProt/Swiss-Prot: BTBDJ_HUMAN
Entrez Gene: 149478
UniGene: 632400
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Btbd19
Rattus norvegicus: Btbd19

1.

Identifier: rs9977638
Cytogenetic Location: 21q21.1
UCSC Genome Browser: View 21q21.1 on the UCSC genome browser

Gene details

HGNC symbol: BTG3
Aliases: ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3
Common name: BTG anti-proliferation factor 3
Description: The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
OMIM: 605674
Ensembl: ENSG00000154640
UniProt/Swiss-Prot: BTG3_HUMAN
Entrez Gene: 10950
UniGene: 473420
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: btg3
Drosophila melanogaster: Tob
Mus musculus: Gm7334
Mus musculus: Btg3
Rattus norvegicus: Btg3

In other databases

CellAge

This gene is present as BTG3

1.

Identifier: rs3763305
Cytogenetic Location: 6p21.32
UCSC Genome Browser: View 6p21.32 on the UCSC genome browser

Gene details

HGNC symbol: BTNL2
Aliases: SS2; BTN7; BTL-II; HSBLMHC1
Common name: butyrophilin like 2
Description
OMIM: 606000
Ensembl: ENSG00000204290
UniProt/Swiss-Prot: A0PJV4_HUMAN
Entrez Gene: 56244
UniGene: 534471
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: zgc:123297
Danio rerio: zgc:162154
Danio rerio: CABZ01059909.1
Danio rerio: zgc:175177
Danio rerio: CABZ01059912.2
Danio rerio: cabz01076234.2
Danio rerio: CABZ01059909.2
Mus musculus: Btnl2
Rattus norvegicus: Btnl2

1.

Identifier: rs1042663
Cytogenetic Location: 6p21.33
UCSC Genome Browser: View 6p21.33 on the UCSC genome browser

Gene details

HGNC symbol: C2
Aliases: CO2; ARMD14
Common name: complement C2
Description: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
OMIM: 613927
Ensembl: ENSG00000166278
UniProt/Swiss-Prot: A0A0G2JL69_HUMAN
Entrez Gene: 717
UniGene: 408903
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: C2
Mus musculus: C2
Rattus norvegicus: C2

In other databases

GenAge microarray genes

This gene is present as C2

1.

Identifier: rs6115865
Cytogenetic Location: 20p13
UCSC Genome Browser: View 20p13 on the UCSC genome browser

Gene details

HGNC symbol: C20orf194
Aliases
Common name: chromosome 20 open reading frame 194
Description: This gene encodes an uncharacterized protein with a C-terminal coiled-coil region. The gene is located on chromosome 20p13 in a 1.8 Mb region linked to a spinocerebellar ataxia phenotype, but this gene does not appear to be a disease candidate. [provided by RefSeq, Dec 2011]
OMIM: 614146
Ensembl: ENSG00000088854
UniProt/Swiss-Prot: CT194_HUMAN
Entrez Gene: 25943
UniGene: 516853
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: si:ch211-194c3.5
Mus musculus: 4930402H24Rik
Rattus norvegicus: RGD1565616

1.

Identifier: rs6105966
Cytogenetic Location: 20p11.23
UCSC Genome Browser: View 20p11.23 on the UCSC genome browser

Gene details

HGNC symbol: C20orf78
Aliases: dJ1068E13.1
Common name: chromosome 20 open reading frame 78
Description
OMIM
Ensembl
UniProt/Swiss-Prot: CT078_HUMAN
Entrez Gene: 100128496
UniGene: 664484
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1867102
Cytogenetic Location: 9q22.32
UCSC Genome Browser: View 9q22.32 on the UCSC genome browser

Gene details

HGNC symbol: C9orf3
Aliases: APO; AP-O; AOPEP; ONPEP; C90RF3
Common name: chromosome 9 open reading frame 3
Description: This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
OMIM
Ensembl: ENSG00000148120
UniProt/Swiss-Prot: AMPO_HUMAN
Entrez Gene: 84909
UniGene: 434253
HapMap: View on HapMap

Homologs in model organisms

Drosophila melanogaster: CG10602
Mus musculus: 2010111I01Rik
Rattus norvegicus: Npepo
Saccharomyces cerevisiae: LAP2

1.

Identifier: rs7127390
Cytogenetic Location: 11q23.3
UCSC Genome Browser: View 11q23.3 on the UCSC genome browser

Gene details

HGNC symbol: CADM1
Aliases: BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1
Common name: cell adhesion molecule 1
Description
OMIM: 605686
Ensembl: ENSG00000182985
UniProt/Swiss-Prot: A0A4Z1_HUMAN
Entrez Gene: 23705
UniGene: 370510
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: cadm1a
Danio rerio: cadm1b
Mus musculus: Cadm1
Rattus norvegicus: Cadm1

1.

Identifier: rs2032563
Cytogenetic Location: 1p36.31-p36.23
UCSC Genome Browser: View 1p36.31-p36.23 on the UCSC genome browser

Gene details

HGNC symbol: CAMTA1
Aliases: CANPMR
Common name: calmodulin binding transcription activator 1
Description: The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
OMIM: 611501
Ensembl: ENSG00000171735
UniProt/Swiss-Prot: CMTA1_HUMAN
Entrez Gene: 23261
UniGene: 397705
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: camt-1
Danio rerio: camta1b
Danio rerio: camta1a
Drosophila melanogaster: Camta
Mus musculus: Camta1
Rattus norvegicus: Camta1

1.

Identifier: rs1016339
Cytogenetic Location: 2p16.1
UCSC Genome Browser: View 2p16.1 on the UCSC genome browser

Gene details

HGNC symbol: CCDC85A
Aliases
Common name: coiled-coil domain containing 85A
Description
OMIM
Ensembl: ENSG00000055813
UniProt/Swiss-Prot: CC85A_HUMAN
Entrez Gene: 114800
UniGene: 117136
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: picc-1
Danio rerio: ccdc85a
Danio rerio: ccdc85al
Drosophila melanogaster: CG17265
Mus musculus: Ccdc85a
Rattus norvegicus: AABR07065498.1

1.

Identifier: rs2277509
Cytogenetic Location: 14q32.11-q32.12
UCSC Genome Browser: View 14q32.11-q32.12 on the UCSC genome browser

Gene details

HGNC symbol: CCDC88C
Aliases: DAPLE; HKRP2; SCA40; KIAA1509
Common name: coiled-coil domain containing 88C
Description: This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]
OMIM: 611204
Ensembl: ENSG00000015133
UniProt/Swiss-Prot: B4DZB8_HUMAN
Entrez Gene: 440193
UniGene: 525536
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: grdn-1
Danio rerio: ccdc88c
Drosophila melanogaster: Girdin
Mus musculus: Ccdc88c
Rattus norvegicus: Ccdc88c

1.

Identifier: rs7800926
Cytogenetic Location: 7q21.13
UCSC Genome Browser: View 7q21.13 on the UCSC genome browser

Gene details

HGNC symbol: CDK14
Aliases: PFTK1; PFTAIRE1
Common name: cyclin dependent kinase 14
Description: PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
OMIM: 610679
Ensembl: ENSG00000058091
UniProt/Swiss-Prot: B4DK59_HUMAN
Entrez Gene: 5218
UniGene: 258576
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ZC123.4
Danio rerio: cdk14
Drosophila melanogaster: Eip63E
Mus musculus: Cdk14
Rattus norvegicus: Cdk14
Saccharomyces cerevisiae: PHO85

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as PHO85

1.

Identifier: rs4729049
Cytogenetic Location: 7q21.2
UCSC Genome Browser: View 7q21.2 on the UCSC genome browser

Gene details

HGNC symbol: CDK6
Aliases: MCPH12; PLSTIRE
Common name: cyclin dependent kinase 6
Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
OMIM: 603368
Ensembl: ENSG00000105810
UniProt/Swiss-Prot: CDK6_HUMAN
Entrez Gene: 1021
UniGene: 119882
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: cdk-4
Caenorhabditis elegans: F52B5.2
Danio rerio: cdk6
Drosophila melanogaster: Cdk4
Mus musculus: Gm16505
Mus musculus: E030030I06Rik
Rattus norvegicus: Cdk6
Saccharomyces cerevisiae: CDC28

In other databases

CellAge

This gene is present as CDK6

1.

Identifier: rs1063192
Cytogenetic Location: 9p21.3
UCSC Genome Browser: View 9p21.3 on the UCSC genome browser

Gene details

HGNC symbol: CDKN2B
Aliases: P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
Common name: cyclin dependent kinase inhibitor 2B
Description: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
OMIM: 600431
Ensembl: ENSG00000147883
UniProt/Swiss-Prot: CDN2B_HUMAN
Entrez Gene: 1030
UniGene: 72901
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: cdkn2a/b
Mus musculus: Cdkn2b
Rattus norvegicus: Cdkn2b

In other databases

GenAge human genes

This gene is present as CDKN2B

CellAge

This gene is present as CDKN2B

CellAge gene expression

This gene is present as CDKN2B

1.

Identifier: rs4977756
Cytogenetic Location: 9p21.3
UCSC Genome Browser: View 9p21.3 on the UCSC genome browser

2.

Identifier: rs1412832
Cytogenetic Location: 9p21.3
UCSC Genome Browser: View 9p21.3 on the UCSC genome browser

Gene details

HGNC symbol: CDKN2B-AS1
Aliases: ANRIL; p15AS; PCAT12; CDKN2BAS; CDKN2B-AS; NCRNA00089
Common name: CDKN2B antisense RNA 1
Description: This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
Other longevity studies of this gene: 2
OMIM: 613149
Ensembl: ENSG00000240498
UniProt/Swiss-Prot
Entrez Gene: 100048912
UniGene: 493614
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1280396
Cytogenetic Location: 15q21.3
UCSC Genome Browser: View 15q21.3 on the UCSC genome browser

Gene details

HGNC symbol: CGNL1
Aliases: JACOP; PCING
Common name: cingulin like 1
Description: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
OMIM: 607856
Ensembl: ENSG00000128849
UniProt/Swiss-Prot: CGNL1_HUMAN
Entrez Gene: 84952
UniGene: 148989
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: cgnl1
Mus musculus: Cgnl1
Rattus norvegicus: Cgnl1

1.

Identifier: rs1922263
Cytogenetic Location: 12q23.3
UCSC Genome Browser: View 12q23.3 on the UCSC genome browser

Gene details

HGNC symbol: CHST11
Aliases: C4ST; C4ST1; C4ST-1; HSA269537
Common name: carbohydrate sulfotransferase 11
Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
OMIM: 610128
Ensembl: ENSG00000171310
UniProt/Swiss-Prot: A0A024RBL0_HUMAN
Entrez Gene: 50515
UniGene: 17569
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: chst11
Drosophila melanogaster: CG31743
Mus musculus: Chst11
Rattus norvegicus: Chst11

1.

Identifier: rs9557276
Cytogenetic Location: 13q32.3
UCSC Genome Browser: View 13q32.3 on the UCSC genome browser

Gene details

HGNC symbol: CLYBL
Aliases: CLB
Common name: citrate lyase beta like
Description
OMIM: 609686
Ensembl: ENSG00000125246
UniProt/Swiss-Prot: CLYBL_HUMAN
Entrez Gene: 171425
UniGene: 655642
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: C01G10.7
Danio rerio: clybl
Mus musculus: Clybl
Rattus norvegicus: Clybl

In other databases

GenAge microarray genes

This gene is present as CLYBL

1.

Identifier: rs303006
Cytogenetic Location: 6p22.3
UCSC Genome Browser: View 6p22.3 on the UCSC genome browser

Gene details

HGNC symbol: CMAHP
Aliases: CMAH; CSAH
Common name: cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
Description: Sialic acids are terminal components of the carbohydrate chains of glycoconjugates involved in ligand-receptor, cell-cell, and cell-pathogen interactions. The two most common forms of sialic acid found in mammalian cells are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated derivative, N-glycolylneuraminic acid (Neu5Gc). Studies of sialic acid distribution show that Neu5Gc is not detectable in normal human tissues although it was an abundant sialic acid in other mammals. Neu5Gc is, in actuality, immunogenic in humans. The absense of Neu5Gc in humans is due to a deletion within the human gene CMAH encoding cytidine monophosphate-N-acetylneuraminic acid hydroxylase, an enzyme responsible for Neu5Gc biosynthesis. Sequences encoding the mouse, pig, and chimpanzee hydroxylase enzymes were obtained by cDNA cloning and found to be highly homologous. However, the homologous human cDNA differs from these cDNAs by a 92-bp deletion in the 5' region. This deletion, corresponding to exon 6 of the mouse hydroxylase gene, causes a frameshift mutation and premature termination of the polypeptide chain in human. It seems unlikely that the truncated human hydroxylase mRNA encodes for an active enzyme explaining why Neu5Gc is undetectable in normal human tissues. Human genomic DNA also shows evidence of this deletion which does not occur in the genomes of African great apes. Nonetheless, the CMAH gene maps to 6p21.32 in humans and great apes indicating that mutation of the CMAH gene occurred following human divergence from chimpanzees and bonobos. [provided by RefSeq, Jul 2008]
OMIM: 603209
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 8418
UniGene: 484918
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs216148
Cytogenetic Location: 5q32
UCSC Genome Browser: View 5q32 on the UCSC genome browser

Gene details

HGNC symbol: CSF1R
Aliases: FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
Common name: colony stimulating factor 1 receptor
Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
OMIM: 164770
Ensembl: ENSG00000182578
UniProt/Swiss-Prot: CSF1R_HUMAN
Entrez Gene: 1436
UniGene: 586219
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: csf1rb
Danio rerio: csf1ra
Drosophila melanogaster: Pvr
Mus musculus: Csf1r
Rattus norvegicus: Csf1r

In other databases

GenAge microarray genes

This gene is present as CSF1R

1.

Identifier: rs7013313
Cytogenetic Location: 8q23.3
UCSC Genome Browser: View 8q23.3 on the UCSC genome browser

Gene details

HGNC symbol: CSMD3
Aliases
Common name: CUB and Sushi multiple domains 3
Description
OMIM: 608399
Ensembl: ENSG00000164796
UniProt/Swiss-Prot: CSMD3_HUMAN
Entrez Gene: 114788
UniGene: 91381
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: lev-9
Danio rerio: CSMD3
Danio rerio: si:ch211-236p22.1
Drosophila melanogaster: fw
Mus musculus: Csmd3

1.

Identifier: rs723525
Cytogenetic Location: 2p12
UCSC Genome Browser: View 2p12 on the UCSC genome browser

2.

Identifier: rs4541274
Cytogenetic Location: 2p12
UCSC Genome Browser: View 2p12 on the UCSC genome browser

Gene details

HGNC symbol: CTNNA2
Aliases: CAPR; CTNR; CAP-R; CT114
Common name: catenin alpha 2
Description
Other longevity studies of this gene: 1
OMIM: 114025
Ensembl: ENSG00000066032
UniProt/Swiss-Prot: CTNA2_HUMAN
Entrez Gene: 1496
UniGene: 167368
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: ctnna2
Drosophila melanogaster: alpha-Cat
Mus musculus: Ctnna2
Rattus norvegicus: Ctnna2
Rattus norvegicus: AABR07061178.1

1.

Identifier: rs10509271
Cytogenetic Location: 10q21.3
UCSC Genome Browser: View 10q21.3 on the UCSC genome browser

Gene details

HGNC symbol: CTNNA3
Aliases: VR22; ARVD13
Common name: catenin alpha 3
Description: This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Other longevity studies of this gene: 1
OMIM: 607667
Ensembl: ENSG00000183230
UniProt/Swiss-Prot: A8K141_HUMAN
Entrez Gene: 29119
UniGene: 21375
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: hmp-1
Mus musculus: Ctnna3
Rattus norvegicus: Ctnna3

1.

Identifier: rs1860242
Cytogenetic Location: 5p15.2
UCSC Genome Browser: View 5p15.2 on the UCSC genome browser

Gene details

HGNC symbol: CTNND2
Aliases: GT24; NPRAP
Common name: catenin delta 2
Description: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
OMIM: 604275
Ensembl: ENSG00000169862
UniProt/Swiss-Prot: B4DJU1_HUMAN
Entrez Gene: 1501
UniGene: 314543
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: jac-1
Danio rerio: ctnnd2b
Danio rerio: ctnnd2a
Drosophila melanogaster: p120ctn
Mus musculus: Ctnnd2
Rattus norvegicus: Ctnnd2

1.

Identifier: rs651922
Cytogenetic Location: 11q24.2
UCSC Genome Browser: View 11q24.2 on the UCSC genome browser

Gene details

HGNC symbol: DCPS
Aliases: ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Common name: decapping enzyme, scavenger
Description: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
OMIM: 610534
Ensembl: ENSG00000110063
UniProt/Swiss-Prot: DCPS_HUMAN
Entrez Gene: 28960
UniGene: 504249
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: dcs-1
Danio rerio: dcps
Drosophila melanogaster: CG2091
Mus musculus: Dcps
Rattus norvegicus: Dcps
Saccharomyces cerevisiae: DCS2
Saccharomyces cerevisiae: DCS1
Schizosaccharomyces pombe: nhm1

In other databases

CellAge gene expression

This gene is present as DCPS

1.

Identifier: rs8003961
Cytogenetic Location: 14q22.3
UCSC Genome Browser: View 14q22.3 on the UCSC genome browser

Gene details

HGNC symbol: DLGAP5
Aliases: DLG7; HURP
Common name: DLG associated protein 5
Description
OMIM
Ensembl: ENSG00000126787
UniProt/Swiss-Prot: DLGP5_HUMAN
Entrez Gene: 9787
UniGene: 77695
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: dlgap5
Drosophila melanogaster: mars
Mus musculus: Dlgap5
Rattus norvegicus: Dlgap5

In other databases

CellAge gene expression

This gene is present as DLGAP5

1.

Identifier: rs262883
Cytogenetic Location: 5q35.1
UCSC Genome Browser: View 5q35.1 on the UCSC genome browser

Gene details

HGNC symbol: DOCK2
Aliases: IMD40
Common name: dedicator of cytokinesis 2
Description: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
OMIM: 603122
Ensembl: ENSG00000134516
UniProt/Swiss-Prot: DOCK2_HUMAN
Entrez Gene: 1794
UniGene: 586174
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ced-5
Drosophila melanogaster: mbc
Mus musculus: Dock2
Rattus norvegicus: Dock2
Saccharomyces cerevisiae: 851141

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as YLR422W

1.

Identifier: rs750586
Cytogenetic Location: 9p24.3
UCSC Genome Browser: View 9p24.3 on the UCSC genome browser

Gene details

HGNC symbol: DOCK8
Aliases: MRD2; ZIR8; HEL-205
Common name: dedicator of cytokinesis 8
Description: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
OMIM: 611432
Ensembl: ENSG00000107099
UniProt/Swiss-Prot: DOCK8_HUMAN
Entrez Gene: 81704
UniGene: 132599
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: F46H5.4
Danio rerio: dock8
Drosophila melanogaster: Zir
Mus musculus: Dock8
Rattus norvegicus: Dock8

1.

Identifier: rs1991289
Cytogenetic Location: 18q12.1
UCSC Genome Browser: View 18q12.1 on the UCSC genome browser

Gene details

HGNC symbol: DSG1-AS1
Aliases
Common name: DSG1 antisense RNA 1
Description
OMIM
Ensembl: ENSG00000266729
UniProt/Swiss-Prot
Entrez Gene: 101927718
UniGene: 625473
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1377843
Cytogenetic Location: 3q13.13
UCSC Genome Browser: View 3q13.13 on the UCSC genome browser

Gene details

HGNC symbol: DZIP3
Aliases: UURF2; PPP1R66; hRUL138
Common name: DAZ interacting zinc finger protein 3
Description
OMIM: 608672
Ensembl: ENSG00000198919
UniProt/Swiss-Prot: DZIP3_HUMAN
Entrez Gene: 9666
UniGene: 409210
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Dzip3
Rattus norvegicus: Dzip3

1.

Identifier: rs4751140
Cytogenetic Location: 10q26.3
UCSC Genome Browser: View 10q26.3 on the UCSC genome browser

Gene details

HGNC symbol: EBF3
Aliases: COE3; OE-2; EBF-3; HADDS; O/E-2
Common name: early B-cell factor 3
Description: This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
OMIM: 607407
Ensembl: ENSG00000108001
UniProt/Swiss-Prot: COE3_HUMAN
Entrez Gene: 253738
UniGene: 591374
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: unc-3
Danio rerio: ebf3a
Drosophila melanogaster: kn
Mus musculus: Ebf3
Rattus norvegicus: Ebf3

1.

Identifier: rs12629971
Cytogenetic Location: 3p13
UCSC Genome Browser: View 3p13 on the UCSC genome browser

2.

Identifier: rs6801173
Cytogenetic Location: 3p13
UCSC Genome Browser: View 3p13 on the UCSC genome browser

Gene details

HGNC symbol: EIF4E3
Aliases: eIF-4E3; eIF4E-3
Common name: eukaryotic translation initiation factor 4E family member 3
Description: EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Other longevity studies of this gene: 1
OMIM: 609896
Ensembl: ENSG00000163412
UniProt/Swiss-Prot: IF4E3_HUMAN
Entrez Gene: 317649
UniGene: 581355
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: eif4e3
Mus musculus: Eif4e3
Rattus norvegicus: Eif4e3
Saccharomyces cerevisiae: CDC33

1.

Identifier: rs7319813
Cytogenetic Location: 13q14.11
UCSC Genome Browser: View 13q14.11 on the UCSC genome browser

2.

Identifier: rs7318601
Cytogenetic Location: 13q14.11
UCSC Genome Browser: View 13q14.11 on the UCSC genome browser

Gene details

HGNC symbol: ENOX1
Aliases: CNOX; PIG38; cCNOX; bA64J21.1
Common name: ecto-NOX disulfide-thiol exchanger 1
Description: The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]
Other longevity studies of this gene: 1
OMIM: 610914
Ensembl: ENSG00000120658
UniProt/Swiss-Prot: A0A024RDT8_HUMAN
Entrez Gene: 55068
UniGene: 128258
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: enox1
Drosophila melanogaster: CG10948
Mus musculus: Enox1
Rattus norvegicus: Enox1

1.

Identifier: rs10512392
Cytogenetic Location: 9q31.3
UCSC Genome Browser: View 9q31.3 on the UCSC genome browser

Gene details

HGNC symbol: EPB41L4B
Aliases: CG1; EHM2
Common name: erythrocyte membrane protein band 4.1 like 4B
Description
OMIM: 610340
Ensembl: ENSG00000095203
UniProt/Swiss-Prot: E41LB_HUMAN
Entrez Gene: 54566
UniGene: 591901
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: frm-2
Danio rerio: epb41l4b
Drosophila melanogaster: yrt
Mus musculus: Epb41l4b
Rattus norvegicus: Epb41l4b

1.

Identifier: rs2383722
Cytogenetic Location: 9p21.2
UCSC Genome Browser: View 9p21.2 on the UCSC genome browser

Gene details

HGNC symbol: EQTN
Aliases: AFAF; SPACA8; C9orf11
Common name: equatorin
Description
OMIM
Ensembl: ENSG00000120160
UniProt/Swiss-Prot: EQTN_HUMAN
Entrez Gene: 54586
UniGene: 163070
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Eqtn
Rattus norvegicus: Eqtn

1.

Identifier: rs793017
Cytogenetic Location: 5q35.1
UCSC Genome Browser: View 5q35.1 on the UCSC genome browser

Gene details

HGNC symbol: ERGIC1
Aliases: NET24; ERGIC32; ERGIC-32
Common name: endoplasmic reticulum-golgi intermediate compartment 1
Description: This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]
OMIM
Ensembl: ENSG00000113719
UniProt/Swiss-Prot: ERGI1_HUMAN
Entrez Gene: 57222
UniGene: 509163
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: Y102A11A.6
Danio rerio: ergic1
Mus musculus: Ergic1
Rattus norvegicus: Ergic1
Saccharomyces cerevisiae: ERV46

1.

Identifier: rs17044026
Cytogenetic Location: 1q41
UCSC Genome Browser: View 1q41 on the UCSC genome browser

Gene details

HGNC symbol: ESRRG
Aliases: ERR3; NR3B3; ERRgamma
Common name: estrogen related receptor gamma
Description: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
OMIM: 602969
Ensembl: ENSG00000196482
UniProt/Swiss-Prot: B7Z5E9_HUMAN
Entrez Gene: 2104
UniGene: 444225
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: esrrgb
Danio rerio: esrrga
Drosophila melanogaster: ERR
Mus musculus: Esrrg
Rattus norvegicus: Esrrg

1.

Identifier: rs982764
Cytogenetic Location: 10q23.31
UCSC Genome Browser: View 10q23.31 on the UCSC genome browser

Gene details

HGNC symbol: FAS
Aliases: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Common name: Fas cell surface death receptor
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Other longevity studies of this gene: 1
OMIM: 134637
Ensembl: ENSG00000026103
UniProt/Swiss-Prot: K9J972_HUMAN
Entrez Gene: 355
UniGene: 244139
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: fas
Mus musculus: Fas
Rattus norvegicus: Fas

In other databases

GenAge human genes

This gene is present as FAS

CellAge gene expression

This gene is present as FAS

1.

Identifier: rs7825208
Cytogenetic Location: 8p11.23
UCSC Genome Browser: View 8p11.23 on the UCSC genome browser

Gene details

HGNC symbol: FGFR1
Aliases: CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Common name: fibroblast growth factor receptor 1
Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
OMIM: 136350
Ensembl: ENSG00000077782
UniProt/Swiss-Prot: A0A0S2Z3Q6_HUMAN
Entrez Gene: 2260
UniGene: 264887
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: egl-15
Danio rerio: fgfr1b
Danio rerio: fgfr1a
Danio rerio: fgfr1bl
Drosophila melanogaster: htl
Drosophila melanogaster: btl
Mus musculus: Fgfr1
Rattus norvegicus: Fgfr1

In other databases

GenAge human genes

This gene is present as FGFR1

CellAge

This gene is present as FGFR1

1.

Identifier: rs10510828
Cytogenetic Location: 3p14.2
UCSC Genome Browser: View 3p14.2 on the UCSC genome browser

Gene details

HGNC symbol: FHIT
Aliases: FRA3B; AP3Aase
Common name: fragile histidine triad
Description: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
OMIM: 601153
Ensembl: ENSG00000189283
UniProt/Swiss-Prot: A0A024R366_HUMAN
Entrez Gene: 2272
UniGene: 655995
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: FHIT (1 of many)
Danio rerio: fhit
Mus musculus: Fhit
Saccharomyces cerevisiae: HNT2

1.

Identifier: rs804283
Cytogenetic Location: 8p23.1
UCSC Genome Browser: View 8p23.1 on the UCSC genome browser

Gene details

HGNC symbol: GATA4
Aliases: TOF; ASD2; VSD1; TACHD
Common name: GATA binding protein 4
Description: This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
OMIM: 600576
Ensembl: ENSG00000136574
UniProt/Swiss-Prot: B3KUF4_HUMAN
Entrez Gene: 2626
UniGene: 243987
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: gata4
Drosophila melanogaster: pnr
Mus musculus: Gata4
Rattus norvegicus: Gata4
Saccharomyces cerevisiae: GLN3
Saccharomyces cerevisiae: DAL80
Saccharomyces cerevisiae: GZF3
Saccharomyces cerevisiae: GAT1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as GLN3

CellAge

This gene is present as GATA4

1.

Identifier: rs358256
Cytogenetic Location: 4p15.2
UCSC Genome Browser: View 4p15.2 on the UCSC genome browser

Gene details

HGNC symbol: GBA3
Aliases: CBG; GLUC; KLRP; CBGL1
Common name: glucosylceramidase beta 3 (gene/pseudogene)
Description: The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]
OMIM: 606619
Ensembl: ENSG00000249948
UniProt/Swiss-Prot: A8K9N1_HUMAN
Entrez Gene: 57733
UniGene: 653107
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: gba3
Rattus norvegicus: Gba3

1.

Identifier: rs17702471
Cytogenetic Location: 13q31.3-q32.1
UCSC Genome Browser: View 13q31.3-q32.1 on the UCSC genome browser

Gene details

HGNC symbol: GPC6
Aliases: OMIMD1
Common name: glypican 6
Description: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
OMIM: 604404
Ensembl: ENSG00000183098
UniProt/Swiss-Prot: GPC6_HUMAN
Entrez Gene: 10082
UniGene: 444329
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: gpn-1
Danio rerio: CABZ01086393.1
Danio rerio: gpc6a
Danio rerio: gpc6b
Drosophila melanogaster: dlp
Mus musculus: Gpc6
Rattus norvegicus: Gpc6

1.

Identifier: rs933664
Cytogenetic Location: 16p12.1
UCSC Genome Browser: View 16p12.1 on the UCSC genome browser

Gene details

HGNC symbol: GSG1L
Aliases: PRO19651
Common name: GSG1 like
Description
OMIM: 617161
Ensembl: ENSG00000169181
UniProt/Swiss-Prot: B3KY67_HUMAN
Entrez Gene: 146395
UniGene: 91910
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: gsg1l
Mus musculus: Gsg1l

1.

Identifier: rs1005321
Cytogenetic Location: 17p12
UCSC Genome Browser: View 17p12 on the UCSC genome browser

Gene details

HGNC symbol: HS3ST3B1
Aliases: 3OST3B1; 3-OST-3B; h3-OST-3B
Common name: heparan sulfate-glucosamine 3-sulfotransferase 3B1
Description: The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
OMIM: 604058
Ensembl: ENSG00000125430
UniProt/Swiss-Prot: HS3SB_HUMAN
Entrez Gene: 9953
UniGene: 48384
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: hst-3.2
Caenorhabditis elegans: hst-3.2
Danio rerio: 100329339
Danio rerio: hs3st3b1b
Danio rerio: hs3st3b1b
Danio rerio: 100329339
Drosophila melanogaster: Hs3st-B
Drosophila melanogaster: Hs3st-B
Mus musculus: Hs3st3b1
Mus musculus: Hs3st3b1
Mus musculus: Hs3st3a1
Mus musculus: Hs3st3a1
Rattus norvegicus: Hs3st3b1
Rattus norvegicus: Hs3st3a1
Rattus norvegicus: Hs3st3b1
Rattus norvegicus: Hs3st3a1

1.

Identifier: rs1503434
Cytogenetic Location: 3p11.2-p11.1
UCSC Genome Browser: View 3p11.2-p11.1 on the UCSC genome browser

Gene details

HGNC symbol: HTR1F
Aliases: 5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F
Common name: 5-hydroxytryptamine receptor 1F
Description
OMIM: 182134
Ensembl: ENSG00000179097
UniProt/Swiss-Prot: 5HT1F_HUMAN
Entrez Gene: 3355
UniGene: 248136
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ser-4
Danio rerio: htr1fa
Danio rerio: htr1fb
Drosophila melanogaster: 5-HT1B
Drosophila melanogaster: 5-HT1A
Mus musculus: Htr1f
Rattus norvegicus: Htr1f

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as ser-4

1.

Identifier: rs2243115
Cytogenetic Location: 3q25.33
UCSC Genome Browser: View 3q25.33 on the UCSC genome browser

Gene details

HGNC symbol: IL12A
Aliases: P35; CLMF; NFSK; NKSF1; IL-12A
Common name: interleukin 12A
Description: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 1
OMIM: 161560
Ensembl: ENSG00000168811
UniProt/Swiss-Prot: IL12A_HUMAN
Entrez Gene: 3592
UniGene: 673
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Il12a
Rattus norvegicus: Il12a

1.

Identifier: rs2432143
Cytogenetic Location: 5q11.2
UCSC Genome Browser: View 5q11.2 on the UCSC genome browser

Gene details

HGNC symbol: ITGA1
Aliases: VLA1; CD49a
Common name: integrin subunit alpha 1
Description: This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
OMIM: 192968
Ensembl: ENSG00000213949
UniProt/Swiss-Prot: ITA1_HUMAN
Entrez Gene: 3672
UniGene: 644352
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: itga1
Drosophila melanogaster: ItgalphaPS5
Drosophila melanogaster: ItgalphaPS4
Drosophila melanogaster: scb
Mus musculus: Itga1
Rattus norvegicus: Itga1

1.

Identifier: rs9304496
Cytogenetic Location: 18q11.2
UCSC Genome Browser: View 18q11.2 on the UCSC genome browser

Gene details

HGNC symbol: KCTD1
Aliases: SENS; C18orf5
Common name: potassium channel tetramerization domain containing 1
Description
OMIM: 613420
Ensembl: ENSG00000134504
UniProt/Swiss-Prot: A0A024RC45_HUMAN
Entrez Gene: 284252
UniGene: 526630
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: kctd1
Drosophila melanogaster: CG10440
Mus musculus: Kctd1
Rattus norvegicus: Kctd1

1.

Identifier: rs6991271
Cytogenetic Location: 8p12
UCSC Genome Browser: View 8p12 on the UCSC genome browser

Gene details

HGNC symbol: KIF13B
Aliases: GAKIN
Common name: kinesin family member 13B
Description
OMIM: 607350
Ensembl: ENSG00000197892
UniProt/Swiss-Prot: KI13B_HUMAN
Entrez Gene: 23303
UniGene: 444767
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: klp-4
Danio rerio: kif13ba
Danio rerio: kif13bb
Drosophila melanogaster: Khc-73
Mus musculus: Kif13b
Rattus norvegicus: Kif13b
Saccharomyces cerevisiae: KIP1
Saccharomyces cerevisiae: CIN8

1.

Identifier: rs2232548
Cytogenetic Location: 12p13.31
UCSC Genome Browser: View 12p13.31 on the UCSC genome browser

Gene details

HGNC symbol: KLRF1
Aliases: NKp80; CLEC5C
Common name: killer cell lectin like receptor F1
Description: KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
OMIM: 605029
Ensembl: ENSG00000150045
UniProt/Swiss-Prot: A0A0C4DFN7_HUMAN
Entrez Gene: 51348
UniGene: 183125
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs5754682
Cytogenetic Location: 22q12.3
UCSC Genome Browser: View 22q12.3 on the UCSC genome browser

Gene details

HGNC symbol: LARGE1
Aliases: LARGE; MDC1D; MDDGA6; MDDGB6
Common name: LARGE xylosyl- and glucuronyltransferase 1
Description: This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
OMIM: 603590
Ensembl: ENSG00000133424
UniProt/Swiss-Prot: LARG1_HUMAN
Entrez Gene: 9215
UniGene: 474667
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: lge-1
Danio rerio: large
Mus musculus: Large1
Rattus norvegicus: Large1

1.

Identifier: rs997675
Cytogenetic Location: 9p21.2
UCSC Genome Browser: View 9p21.2 on the UCSC genome browser

Gene details

HGNC symbol: LINC00032
Aliases: C9orf14; NCRNA00032
Common name: long intergenic non-protein coding RNA 32
Description
OMIM
Ensembl: ENSG00000283945
UniProt/Swiss-Prot
Entrez Gene: 158035
UniGene: 201554
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs10084768
Cytogenetic Location: 4p15.33
UCSC Genome Browser: View 4p15.33 on the UCSC genome browser

Gene details

HGNC symbol: LINC01182
Aliases
Common name: long intergenic non-protein coding RNA 1182
Description
OMIM
Ensembl: ENSG00000250634
UniProt/Swiss-Prot
Entrez Gene: 101929071
UniGene: 543714
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs336264
Cytogenetic Location: 12q24.13
UCSC Genome Browser: View 12q24.13 on the UCSC genome browser

Gene details

HGNC symbol: LINC01234
Aliases: LCAL84; onco-lncRNA-32
Common name: long intergenic non-protein coding RNA 1234
Description
OMIM
Ensembl: ENSG00000249550
UniProt/Swiss-Prot
Entrez Gene: 100506465
UniGene: 211461
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs10210870
Cytogenetic Location: 2p25.3
UCSC Genome Browser: View 2p25.3 on the UCSC genome browser

Gene details

HGNC symbol: LINC01250
Aliases
Common name: long intergenic non-protein coding RNA 1250
Description
OMIM
Ensembl: ENSG00000234423
UniProt/Swiss-Prot
Entrez Gene: 101927554
UniGene: 638446
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs4073968
Cytogenetic Location: 4p14
UCSC Genome Browser: View 4p14 on the UCSC genome browser

Gene details

HGNC symbol: LINC01258
Aliases
Common name: long intergenic non-protein coding RNA 1258
Description
OMIM
Ensembl: ENSG00000249534
UniProt/Swiss-Prot
Entrez Gene: 101928776
UniGene: 586147
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs15606
Cytogenetic Location: 3q24
UCSC Genome Browser: View 3q24 on the UCSC genome browser

Gene details

HGNC symbol: LINC02032
Aliases
Common name: long intergenic non-protein coding RNA 2032
Description
OMIM
Ensembl: ENSG00000241131
UniProt/Swiss-Prot
Entrez Gene: 100507461
UniGene: 112623
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1456669
Cytogenetic Location: 3q24
UCSC Genome Browser: View 3q24 on the UCSC genome browser

Gene details

HGNC symbol: LINC02045
Aliases
Common name: long intergenic non-protein coding RNA 2045
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105374146
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs3803833
Cytogenetic Location: 17q24.3
UCSC Genome Browser: View 17q24.3 on the UCSC genome browser

Gene details

HGNC symbol: LINC02095
Aliases
Common name: long intergenic non-protein coding RNA 2095
Description
OMIM
Ensembl: ENSG00000228639
UniProt/Swiss-Prot
Entrez Gene: 102723505
UniGene: 547482
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs337656
Cytogenetic Location: 12q22
UCSC Genome Browser: View 12q22 on the UCSC genome browser

Gene details

HGNC symbol: LINC02391
Aliases
Common name: long intergenic non-protein coding RNA 2391
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 101930023
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs697887
Cytogenetic Location: 12q24.21
UCSC Genome Browser: View 12q24.21 on the UCSC genome browser

Gene details

HGNC symbol: LINC02463
Aliases
Common name: long intergenic non-protein coding RNA 2463
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105370004
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs7853840
Cytogenetic Location: 9p21.2-p21.1
UCSC Genome Browser: View 9p21.2-p21.1 on the UCSC genome browser

Gene details

HGNC symbol: LINGO2
Aliases: LERN3; LRRN6C
Common name: leucine rich repeat and Ig domain containing 2
Description
OMIM: 609793
Ensembl: ENSG00000174482
UniProt/Swiss-Prot: LIGO2_HUMAN
Entrez Gene: 158038
UniGene: 444665
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: lingo2a
Danio rerio: lingo2b
Drosophila melanogaster: Fili
Mus musculus: Lingo2
Rattus norvegicus: Lingo2

In other databases

CellAge gene expression

This gene is present as LINGO2

1.

Identifier: rs915179
In Other Studies (IDs): 549
Cytogenetic Location: 1q22
UCSC Genome Browser: View 1q22 on the UCSC genome browser

Gene details

HGNC symbol: LMNA
Aliases: FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
Common name: lamin A/C
Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Other longevity studies of this gene: 12
OMIM: 150330
Ensembl: ENSG00000160789
UniProt/Swiss-Prot: LMNA_HUMAN
Entrez Gene: 4000
UniGene: 594444
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: lmn-1
Danio rerio: lmna
Drosophila melanogaster: LamC
Drosophila melanogaster: Lam
Mus musculus: Lmna
Rattus norvegicus: Lmna

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as lmn-1
A homolog of this gene for Mus musculus is present as Lmna

GenAge human genes

This gene is present as LMNA

GenAge microarray genes

This gene is present as LMNA

CellAge

This gene is present as LMNA

1.

Identifier: rs3906146
Cytogenetic Location: 9q33.3
UCSC Genome Browser: View 9q33.3 on the UCSC genome browser

Gene details

HGNC symbol: LMX1B
Aliases: NPS1; LMX1.2
Common name: LIM homeobox transcription factor 1 beta
Description: This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
OMIM: 602575
Ensembl: ENSG00000136944
UniProt/Swiss-Prot: B7ZLH2_HUMAN
Entrez Gene: 4010
UniGene: 129133
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: lim-6
Danio rerio: lmx1bb
Danio rerio: lmx1ba
Drosophila melanogaster: CG32105
Drosophila melanogaster: CG4328
Mus musculus: Lmx1b
Rattus norvegicus: Lmx1b

1.

Identifier: rs2158860
Cytogenetic Location: 7p21.1
UCSC Genome Browser: View 7p21.1 on the UCSC genome browser

Gene details

HGNC symbol: LOC101927668
Aliases
Common name: uncharacterized LOC101927668
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 101927668
UniGene: 715900
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs2312243
Cytogenetic Location: 5q23.3
UCSC Genome Browser: View 5q23.3 on the UCSC genome browser

Gene details

HGNC symbol: LOC102723654
Aliases
Common name: uncharacterized LOC102723654
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 102723654
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs12044217
Cytogenetic Location: 1q42.12
UCSC Genome Browser: View 1q42.12 on the UCSC genome browser

Gene details

HGNC symbol: LOC102723834
Aliases
Common name: uncharacterized LOC102723834
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 102723834
UniGene: 634554
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1796412
Cytogenetic Location: 12q24.31
UCSC Genome Browser: View 12q24.31 on the UCSC genome browser

Gene details

HGNC symbol: LOC105370031
Aliases
Common name: uncharacterized LOC105370031
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105370031
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs7149754
Cytogenetic Location: 14q32.2
UCSC Genome Browser: View 14q32.2 on the UCSC genome browser

Gene details

HGNC symbol: LOC105370656
Aliases
Common name: uncharacterized LOC105370656
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105370656
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs2061450
Cytogenetic Location: 18q21.33
UCSC Genome Browser: View 18q21.33 on the UCSC genome browser

Gene details

HGNC symbol: LOC105372161
Aliases
Common name: uncharacterized LOC105372161
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105372161
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs6657655
Cytogenetic Location: 1q42.3
UCSC Genome Browser: View 1q42.3 on the UCSC genome browser

Gene details

HGNC symbol: LOC105373215
Aliases
Common name: uncharacterized LOC105373215
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105373215
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs12737127
Cytogenetic Location: 1q43
UCSC Genome Browser: View 1q43 on the UCSC genome browser

Gene details

HGNC symbol: LOC105373220
Aliases
Common name: uncharacterized LOC105373220
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105373220
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs4363980
Cytogenetic Location: 2q24.1
UCSC Genome Browser: View 2q24.1 on the UCSC genome browser

Gene details

HGNC symbol: LOC105373714
Aliases
Common name: uncharacterized LOC105373714
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105373714
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs10505391
Cytogenetic Location: 8q24.12
UCSC Genome Browser: View 8q24.12 on the UCSC genome browser

Gene details

HGNC symbol: LOC105375731
Aliases
Common name: uncharacterized LOC105375731
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105375731
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs923520
Cytogenetic Location: 5q35.2
UCSC Genome Browser: View 5q35.2 on the UCSC genome browser

Gene details

HGNC symbol: LOC105377739
Aliases
Common name: uncharacterized LOC105377739
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105377739
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1395451
Cytogenetic Location: 6q14.1
UCSC Genome Browser: View 6q14.1 on the UCSC genome browser

Gene details

HGNC symbol: LOC105377865
Aliases
Common name: uncharacterized LOC105377865
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105377865
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs10140519
Cytogenetic Location: 14q21.3
UCSC Genome Browser: View 14q21.3 on the UCSC genome browser

Gene details

HGNC symbol: LOC105378178
Aliases
Common name: uncharacterized LOC105378178
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105378178
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs954472
Cytogenetic Location: 1p22.2
UCSC Genome Browser: View 1p22.2 on the UCSC genome browser

Gene details

HGNC symbol: LOC105378852
Aliases
Common name: uncharacterized LOC105378852
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 105378852
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs4237774
Cytogenetic Location: 11p15.4
UCSC Genome Browser: View 11p15.4 on the UCSC genome browser

Gene details

HGNC symbol: LOC107984303
Aliases
Common name: uncharacterized LOC107984303
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 107984303
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs4802234
Cytogenetic Location: 19q13.31-q13.32
UCSC Genome Browser: View 19q13.31-q13.32 on the UCSC genome browser

Gene details

HGNC symbol: LOC107985305
Aliases
Common name: uncharacterized LOC107985305
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 107985305
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1463990
Cytogenetic Location: 2q36.1
UCSC Genome Browser: View 2q36.1 on the UCSC genome browser

Gene details

HGNC symbol: LOC107985988
Aliases
Common name: uncharacterized LOC107985988
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 107985988
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs2201186
Cytogenetic Location: 4p15.33
UCSC Genome Browser: View 4p15.33 on the UCSC genome browser

2.

Identifier: rs3886917
Cytogenetic Location: 4p15.33
UCSC Genome Browser: View 4p15.33 on the UCSC genome browser

Gene details

HGNC symbol: LOC107986178
Aliases
Common name: uncharacterized LOC107986178
Description
Other longevity studies of this gene: 1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 107986178
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs11218921
Cytogenetic Location: 11q24.1
UCSC Genome Browser: View 11q24.1 on the UCSC genome browser

Gene details

HGNC symbol: LOC341056
Aliases
Common name: SUMO1 activating enzyme subunit 1 pseudogene
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 341056
UniGene: 620309
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs4570560
Cytogenetic Location: 11p11.12
UCSC Genome Browser: View 11p11.12 on the UCSC genome browser

Gene details

HGNC symbol: LOC387770
Aliases
Common name: tripartite motif containing 49D1 pseudogene
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene: 387770
UniGene
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs12960908
Cytogenetic Location: 18q22.3
UCSC Genome Browser: View 18q22.3 on the UCSC genome browser

Gene details

HGNC symbol: LOC400655
Aliases
Common name: uncharacterized LOC400655
Description
OMIM
Ensembl: ENSG00000263711
UniProt/Swiss-Prot
Entrez Gene: 400655
UniGene: 579378
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs1898422
Cytogenetic Location: 2q22.1-q22.2
UCSC Genome Browser: View 2q22.1-q22.2 on the UCSC genome browser

Gene details

HGNC symbol: LRP1B
Aliases: LRP-1B; LRPDIT; LRP-DIT
Common name: LDL receptor related protein 1B
Description: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
Other longevity studies of this gene: 1
OMIM: 608766
Ensembl: ENSG00000168702
UniProt/Swiss-Prot: LRP1B_HUMAN
Entrez Gene: 53353
UniGene: 656461
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: F14B4.1
Danio rerio: lrp1ba
Drosophila melanogaster: LRP1
Mus musculus: Lrp1b
Rattus norvegicus: Lrp1b

1.

Identifier: rs2242653
Cytogenetic Location: 6p21.33
UCSC Genome Browser: View 6p21.33 on the UCSC genome browser

Gene details

HGNC symbol: LY6G6F
Aliases: G6f; NG32; LY6G6; LY6G6D; C6orf21
Common name: lymphocyte antigen 6 family member G6F
Description: The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]
OMIM: 611404
Ensembl: ENSG00000204424
UniProt/Swiss-Prot: A0A1L6Z9Z3_HUMAN
Entrez Gene: 259215
UniGene: 591794
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Ly6g6f
Rattus norvegicus: Ly6g6f

1.

Identifier: rs3804474
Cytogenetic Location: 6p25.1
UCSC Genome Browser: View 6p25.1 on the UCSC genome browser

Gene details

HGNC symbol: LY86
Aliases: MD1; MD-1; MMD-1; dJ80N2.1
Common name: lymphocyte antigen 86
Description
OMIM: 605241
Ensembl: ENSG00000112799
UniProt/Swiss-Prot: LY86_HUMAN
Entrez Gene: 9450
UniGene: 653138
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: ly86
Mus musculus: Ly86
Rattus norvegicus: Ly86

In other databases

GenAge microarray genes

This gene is present as LY86

1.

Identifier: rs7524519
Cytogenetic Location: 1q41
UCSC Genome Browser: View 1q41 on the UCSC genome browser

Gene details

HGNC symbol: LYPLAL1
Aliases: Q96AV0
Common name: lysophospholipase like 1
Description
OMIM: 616548
Ensembl: ENSG00000143353
UniProt/Swiss-Prot: LYPL1_HUMAN
Entrez Gene: 127018
UniGene: 657617
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: lyplal1
Danio rerio: lyplal1
Drosophila melanogaster: CG6567
Mus musculus: Lyplal1
Rattus norvegicus: Lyplal1
Saccharomyces cerevisiae: 850809

1.

Identifier: rs9554632
Cytogenetic Location: 13q31.2
UCSC Genome Browser: View 13q31.2 on the UCSC genome browser

Gene details

HGNC symbol: MIR4500HG
Aliases
Common name: MIR4500 host gene
Description
OMIM
Ensembl: ENSG00000228824
UniProt/Swiss-Prot
Entrez Gene: 642345
UniGene: 508337
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs5758008
Cytogenetic Location: 22q13.1-q13.2
UCSC Genome Browser: View 22q13.1-q13.2 on the UCSC genome browser

Gene details

HGNC symbol: MKL1
Aliases: MAL; BSAC; MRTF-A
Common name: megakaryoblastic leukemia (translocation) 1
Description: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
OMIM: 606078
Ensembl: ENSG00000196588
UniProt/Swiss-Prot: A4FUJ8_HUMAN
Entrez Gene: 57591
UniGene: 654688
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: mkl1b
Danio rerio: mkl1a
Drosophila melanogaster: Mrtf
Mus musculus: Mkl1
Rattus norvegicus: Mkl1

In other databases

CellAge

This gene is present as MRTFA

1.

Identifier: rs7246865
Cytogenetic Location: 19p13.11
UCSC Genome Browser: View 19p13.11 on the UCSC genome browser

Gene details

HGNC symbol: MYO9B
Aliases: MYR5; CELIAC4
Common name: myosin IXB
Description: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
OMIM: 602129
Ensembl: ENSG00000099331
UniProt/Swiss-Prot: B0I1T6_HUMAN
Entrez Gene: 4650
UniGene: 123198
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: hum-7
Danio rerio: MYO9B (1 of many)
Danio rerio: myo9b
Mus musculus: Myo9b
Rattus norvegicus: Myo9b
Saccharomyces cerevisiae: MYO2

1.

Identifier: rs10190125
Cytogenetic Location: 2p25.3
UCSC Genome Browser: View 2p25.3 on the UCSC genome browser

Gene details

HGNC symbol: MYT1L
Aliases: NZF1; MRD39; myT1-L; ZC2H2C2; ZC2HC4B
Common name: myelin transcription factor 1 like
Description: This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
OMIM: 613084
Ensembl: ENSG00000186487
UniProt/Swiss-Prot: MYT1L_HUMAN
Entrez Gene: 23040
UniGene: 434418
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ztf-11
Danio rerio: myt1la
Drosophila melanogaster: CG43689
Mus musculus: Myt1l
Rattus norvegicus: Myt1l

1.

Identifier: rs894558
Cytogenetic Location: 11p15.1
UCSC Genome Browser: View 11p15.1 on the UCSC genome browser

Gene details

HGNC symbol: NAV2
Aliases: HELAD1; RAINB1; POMFIL2; UNC53H2; STEERIN2
Common name: neuron navigator 2
Description: This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
OMIM: 607026
Ensembl: ENSG00000166833
UniProt/Swiss-Prot: A7E2D6_HUMAN
Entrez Gene: 89797
UniGene: 64341
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: unc-53
Danio rerio: nav2a
Danio rerio: nav2b
Drosophila melanogaster: sick
Mus musculus: Nav2
Rattus norvegicus: Nav2

1.

Identifier: rs9530108
Cytogenetic Location: 13q13.3
UCSC Genome Browser: View 13q13.3 on the UCSC genome browser

Gene details

HGNC symbol: NBEA
Aliases: BCL8B; LYST2
Common name: neurobeachin
Description: This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
OMIM: 604889
Ensembl: ENSG00000172915
UniProt/Swiss-Prot: B3KXQ8_HUMAN
Entrez Gene: 26960
UniGene: 491172
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: sel-2
Danio rerio: nbeab
Danio rerio: nbeaa
Drosophila melanogaster: rg
Mus musculus: Nbea
Saccharomyces cerevisiae: BPH1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as BPH1

1.

Identifier: rs4647992
Cytogenetic Location: 4q24
UCSC Genome Browser: View 4q24 on the UCSC genome browser

Gene details

HGNC symbol: NFKB1
Aliases: p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
Common name: nuclear factor kappa B subunit 1
Description: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Other longevity studies of this gene: 1
OMIM: 164011
Ensembl: ENSG00000109320
UniProt/Swiss-Prot: A0A024RDJ4_HUMAN
Entrez Gene: 4790
UniGene: 618430
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: nfkb1
Drosophila melanogaster: Rel
Mus musculus: Nfkb1
Rattus norvegicus: Nfkb1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Nfkb1

GenAge human genes

This gene is present as NFKB1

GenAge microarray genes

This gene is present as NFKB1

1.

Identifier: rs2252024
Cytogenetic Location: 15q26.2
UCSC Genome Browser: View 15q26.2 on the UCSC genome browser

Gene details

HGNC symbol: NR2F2-AS1
Aliases
Common name: NR2F2 antisense RNA 1
Description
OMIM
Ensembl: ENSG00000247809
UniProt/Swiss-Prot
Entrez Gene: 644192
UniGene: 58690
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs2963154
Cytogenetic Location: 5q31.3
UCSC Genome Browser: View 5q31.3 on the UCSC genome browser

Gene details

HGNC symbol: NR3C1
Aliases: GR; GCR; GRL; GCCR; GCRST
Common name: nuclear receptor subfamily 3 group C member 1
Description: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Other longevity studies of this gene: 4
OMIM: 138040
Ensembl: ENSG00000113580
UniProt/Swiss-Prot: B7Z7I2_HUMAN
Entrez Gene: 2908
UniGene: 122926
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: nr3c1
Mus musculus: Nr3c1
Rattus norvegicus: Nr3c1

In other databases

GenAge human genes

This gene is present as NR3C1

1.

Identifier: rs11153598
Cytogenetic Location: 6q22.1
UCSC Genome Browser: View 6q22.1 on the UCSC genome browser

Gene details

HGNC symbol: NT5DC1
Aliases: LP2642; NT5C2L1; C6orf200
Common name: 5'-nucleotidase domain containing 1
Description: While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. [provided by RefSeq, May 2010]
OMIM
Ensembl: ENSG00000178425
UniProt/Swiss-Prot: NT5D1_HUMAN
Entrez Gene: 221294
UniGene: 520341
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: nt5dc1
Drosophila melanogaster: CG2277
Mus musculus: Nt5dc1
Rattus norvegicus: Nt5dc1

1.

Identifier: rs12155014
Cytogenetic Location: 7p13
UCSC Genome Browser: View 7p13 on the UCSC genome browser

Gene details

HGNC symbol: OGDH
Aliases: E1k; OGDC; AKGDH
Common name: oxoglutarate dehydrogenase
Description: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
OMIM: 613022
Ensembl: ENSG00000105953
UniProt/Swiss-Prot: A0A140VJQ5_HUMAN
Entrez Gene: 4967
UniGene: 488181
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ogdh-1
Danio rerio: ogdhb
Danio rerio: ogdha
Drosophila melanogaster: CG33791
Drosophila melanogaster: Nc73EF
Mus musculus: Ogdh
Rattus norvegicus: LOC103693780
Rattus norvegicus: LOC103693780
Saccharomyces cerevisiae: KGD1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as ogdh-1
A homolog of this gene for Saccharomyces cerevisiae is present as KGD1

1.

Identifier: rs4785393
Cytogenetic Location: 16q12.1
UCSC Genome Browser: View 16q12.1 on the UCSC genome browser

Gene details

HGNC symbol: PAPD5
Aliases: TRF4-2
Common name: poly(A) RNA polymerase D5, non-canonical
Description
OMIM: 605540
Ensembl: ENSG00000121274
UniProt/Swiss-Prot: A0A024R6Q7_HUMAN
Entrez Gene: 64282
UniGene: 514342
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: gld-4
Danio rerio: papd5
Drosophila melanogaster: Trf4-1
Drosophila melanogaster: Trf4-2
Mus musculus: Papd5
Rattus norvegicus: Papd5
Saccharomyces cerevisiae: TRF5
Saccharomyces cerevisiae: PAP2

1.

Identifier: rs701176
Cytogenetic Location: 1q42.2
UCSC Genome Browser: View 1q42.2 on the UCSC genome browser

Gene details

HGNC symbol: PCNX2
Aliases: PCNXL2
Common name: pecanex homolog 2 (Drosophila)
Description: This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. [provided by RefSeq, Jun 2016]
OMIM
Ensembl: ENSG00000135749
UniProt/Swiss-Prot: B3KNZ5_HUMAN
Entrez Gene: 80003
UniGene: 370605
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: B0511.12
Danio rerio: pcnxl2
Drosophila melanogaster: pcx
Mus musculus: Pcnx2
Rattus norvegicus: Pcnx2

1.

Identifier: rs11086106
Cytogenetic Location: 19p13.11
UCSC Genome Browser: View 19p13.11 on the UCSC genome browser

Gene details

HGNC symbol: PGPEP1
Aliases: PGI; PGP; Pcp; PGPI; PAP-I; PGP-I
Common name: pyroglutamyl-peptidase I
Description: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
OMIM: 610694
Ensembl: ENSG00000130517
UniProt/Swiss-Prot: PGPI_HUMAN
Entrez Gene: 54858
UniGene: 131776
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: pgpep1
Drosophila melanogaster: CG32147
Mus musculus: Pgpep1
Rattus norvegicus: Pgpep1

1.

Identifier: rs4871976
Cytogenetic Location: 8p21.3
UCSC Genome Browser: View 8p21.3 on the UCSC genome browser

Gene details

HGNC symbol: PHYHIP
Aliases: PAHX-AP; PAHXAP1; DYRK1AP3
Common name: phytanoyl-CoA 2-hydroxylase interacting protein
Description
OMIM: 608511
Ensembl: ENSG00000168490
UniProt/Swiss-Prot: PHYIP_HUMAN
Entrez Gene: 9796
UniGene: 334688
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: M01B2.13
Caenorhabditis elegans: T10H4.13
Caenorhabditis elegans: M01B2.12
Caenorhabditis elegans: Y92H12BR.7
Caenorhabditis elegans: M01B2.10
Caenorhabditis elegans: T10H4.4
Mus musculus: Phyhip
Rattus norvegicus: Phyhip
Rattus norvegicus: LOC108348161
Rattus norvegicus: LOC108348161

1.

Identifier: rs9916344
Cytogenetic Location: 17p13.2-p13.1
UCSC Genome Browser: View 17p13.2-p13.1 on the UCSC genome browser

Gene details

HGNC symbol: PITPNM3
Aliases: NIR1; ACKR6; CORD5; RDGBA3
Common name: PITPNM family member 3
Description: This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
OMIM: 608921
Ensembl: ENSG00000091622
UniProt/Swiss-Prot: A1A5C9_HUMAN
Entrez Gene: 83394
UniGene: 183983
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: pitpnm3
Drosophila melanogaster: rdgBbeta
Mus musculus: Pitpnm3
Rattus norvegicus: Pitpnm3

1.

Identifier: rs590211
Cytogenetic Location: 11q24.2
UCSC Genome Browser: View 11q24.2 on the UCSC genome browser

Gene details

HGNC symbol: PKNOX2
Aliases: PREP2
Common name: PBX/knotted 1 homeobox 2
Description: Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
OMIM: 613066
Ensembl: ENSG00000165495
UniProt/Swiss-Prot: B7ZAF3_HUMAN
Entrez Gene: 63876
UniGene: 278564
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: pknox2
Mus musculus: Pknox2
Rattus norvegicus: Pknox2
Saccharomyces cerevisiae: CUP9
Saccharomyces cerevisiae: TOS8

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as TOS8
A homolog of this gene for Saccharomyces cerevisiae is present as CUP9

1.

Identifier: rs216493
Cytogenetic Location: 11p15.2-p15.1
UCSC Genome Browser: View 11p15.2-p15.1 on the UCSC genome browser

Gene details

HGNC symbol: PLEKHA7
Aliases
Common name: pleckstrin homology domain containing A7
Description
OMIM: 612686
Ensembl: ENSG00000166689
UniProt/Swiss-Prot: E9PKC0_HUMAN
Entrez Gene: 144100
UniGene: 12332
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: plekha7a
Danio rerio: plekha7b
Drosophila melanogaster: CG34383
Mus musculus: Plekha7
Rattus norvegicus: Plekha7

1.

Identifier: rs1868778
Cytogenetic Location: 7q32.3
UCSC Genome Browser: View 7q32.3 on the UCSC genome browser

Gene details

HGNC symbol: PLXNA4
Aliases: PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003
Common name: plexin A4
Description
OMIM: 604280
Ensembl: ENSG00000221866
UniProt/Swiss-Prot: A0A024R7A6_HUMAN
Entrez Gene: 91584
UniGene: 511454
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: plx-1
Danio rerio: plxna4
Drosophila melanogaster: PlexA
Mus musculus: Plxna4
Rattus norvegicus: Plxna4

1.

Identifier: rs249904
Cytogenetic Location: 5q32
UCSC Genome Browser: View 5q32 on the UCSC genome browser

Gene details

HGNC symbol: PPP2R2B
Aliases: PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA
Common name: protein phosphatase 2 regulatory subunit Bbeta
Description: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]
OMIM: 604325
Ensembl: ENSG00000156475
UniProt/Swiss-Prot: 2ABB_HUMAN
Entrez Gene: 5521
UniGene: 627618
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: sur-6
Danio rerio: ppp2r2ba
Danio rerio: ppp2r2bb
Drosophila melanogaster: tws
Mus musculus: Ppp2r2b
Rattus norvegicus: Ppp2r2b
Saccharomyces cerevisiae: CDC55

1.

Identifier: rs4596036
Cytogenetic Location: 20q13.13
UCSC Genome Browser: View 20q13.13 on the UCSC genome browser

Gene details

HGNC symbol: PREX1
Aliases: P-REX1
Common name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Description: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
OMIM: 606905
Ensembl: ENSG00000124126
UniProt/Swiss-Prot: PREX1_HUMAN
Entrez Gene: 57580
UniGene: 153310
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: prex1
Mus musculus: Prex1
Rattus norvegicus: Prex1
Saccharomyces cerevisiae: CDC24

1.

Identifier: rs3019435
Cytogenetic Location: 6q26
UCSC Genome Browser: View 6q26 on the UCSC genome browser

Gene details

HGNC symbol: PRKN
Aliases: PDJ; AR-JP; LPRS2; PARK2
Common name: parkin RBR E3 ubiquitin protein ligase
Description: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 15
OMIM: 602544
Ensembl: ENSG00000185345
UniProt/Swiss-Prot: PRKN2_HUMAN
Entrez Gene: 5071
UniGene: 132954
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: pdr-1
Danio rerio: park2
Drosophila melanogaster: park
Mus musculus: Park2
Rattus norvegicus: AC135026.1
Rattus norvegicus: AABR07001519.1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as park

CellAge

This gene is present as PRKN

1.

Identifier: rs1517598
Cytogenetic Location: 4p15.32
UCSC Genome Browser: View 4p15.32 on the UCSC genome browser

Gene details

HGNC symbol: PROM1
Aliases: RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
Common name: prominin 1
Description: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
OMIM: 604365
Ensembl: ENSG00000007062
UniProt/Swiss-Prot: A0A0A0N0M1_HUMAN
Entrez Gene: 8842
UniGene: 614734
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: prmn-1
Danio rerio: prom1a
Danio rerio: prom1b
Drosophila melanogaster: prom
Drosophila melanogaster: prominin-like
Drosophila melanogaster: CG45067
Mus musculus: Prom1
Rattus norvegicus: Prom1

1.

Identifier: rs7857137
Cytogenetic Location: 9q21.12
UCSC Genome Browser: View 9q21.12 on the UCSC genome browser

Gene details

HGNC symbol: PTAR1
Aliases
Common name: protein prenyltransferase alpha subunit repeat containing 1
Description
OMIM
Ensembl: ENSG00000188647
UniProt/Swiss-Prot: PTAR1_HUMAN
Entrez Gene: 375743
UniGene: 744192
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: ptar1
Drosophila melanogaster: temp
Mus musculus: Ptar1
Rattus norvegicus: Ptar1

1.

Identifier: rs1033686
Cytogenetic Location: 14q24.1
UCSC Genome Browser: View 14q24.1 on the UCSC genome browser

2.

Identifier: rs4902538
Cytogenetic Location: 14q24.1
UCSC Genome Browser: View 14q24.1 on the UCSC genome browser

Gene details

HGNC symbol: RAD51B
Aliases: REC2; R51H2; RAD51L1
Common name: RAD51 paralog B
Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]
Other longevity studies of this gene: 1
OMIM: 602948
Ensembl: ENSG00000182185
UniProt/Swiss-Prot: A0A024R656_HUMAN
Entrez Gene: 5890
UniGene: 172587
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51b
Mus musculus: Rad51b
Rattus norvegicus: Rad51b
Saccharomyces cerevisiae: RAD51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

1.

Identifier: rs3816754
Cytogenetic Location: 17q12
UCSC Genome Browser: View 17q12 on the UCSC genome browser

Gene details

HGNC symbol: RAD51D
Aliases: TRAD; R51H3; BROVCA4; RAD51L3
Common name: RAD51 paralog D
Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
OMIM: 602954
Ensembl: ENSG00000185379
UniProt/Swiss-Prot: RA51D_HUMAN
Entrez Gene: 5892
UniGene: 631757
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51d
Drosophila melanogaster: Rad51C
Mus musculus: Rad51d
Rattus norvegicus: Rad51d
Saccharomyces cerevisiae: RAD51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

CellAge gene expression

This gene is present as RAD51D

1.

Identifier: rs922943
Cytogenetic Location: 3p24.2
UCSC Genome Browser: View 3p24.2 on the UCSC genome browser

Gene details

HGNC symbol: RARB
Aliases: HAP; RRB2; NR1B2; MCOPS12; RARbeta1
Common name: retinoic acid receptor beta
Description: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
OMIM: 180220
Ensembl: ENSG00000077092
UniProt/Swiss-Prot: F1D8S6_HUMAN
Entrez Gene: 5915
UniGene: 543218
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Rarb
Rattus norvegicus: Rarb

In other databases

CellAge

This gene is present as RARB

1.

Identifier: rs2043270
Cytogenetic Location: 5q33.3
UCSC Genome Browser: View 5q33.3 on the UCSC genome browser

Gene details

HGNC symbol: RNF145
Aliases
Common name: ring finger protein 145
Description
OMIM
Ensembl: ENSG00000145860
UniProt/Swiss-Prot: A8K9Y9_HUMAN
Entrez Gene: 153830
UniGene: 349306
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: Y119C1B.5
Danio rerio: rnf145a
Danio rerio: rnf145b
Mus musculus: Rnf145
Rattus norvegicus: Rnf145
Saccharomyces cerevisiae: HRD1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as HRD1

1.

Identifier: rs12585627
Cytogenetic Location: 13q22.3-q31.1
UCSC Genome Browser: View 13q22.3-q31.1 on the UCSC genome browser

Gene details

HGNC symbol: RNF219-AS1
Aliases: POU4F1-AS1
Common name: RNF219 antisense RNA 1
Description
OMIM
Ensembl: ENSG00000234377
UniProt/Swiss-Prot
Entrez Gene: 100874222
UniGene: 493062
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs2596230
Cytogenetic Location: 15q13.3-q14
UCSC Genome Browser: View 15q13.3-q14 on the UCSC genome browser

Gene details

HGNC symbol: RYR3
Aliases: RYR-3
Common name: ryanodine receptor 3
Description: The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
OMIM: 180903
Ensembl: ENSG00000198838
UniProt/Swiss-Prot: A0A0U1RRH1_HUMAN
Entrez Gene: 6263
UniGene: 709373
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: ryr3
Mus musculus: Ryr3
Rattus norvegicus: Ryr3

1.

Identifier: rs10055012
Cytogenetic Location: 5q23.1
UCSC Genome Browser: View 5q23.1 on the UCSC genome browser

Gene details

HGNC symbol: SEMA6A
Aliases: VIA; SEMA; HT018; SEMAQ; SEMA6A1
Common name: semaphorin 6A
Description: The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
OMIM: 605885
Ensembl: ENSG00000092421
UniProt/Swiss-Prot: A0A0A0MQU6_HUMAN
Entrez Gene: 57556
UniGene: 156967
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: smp-1
Danio rerio: CABZ01112804.2
Drosophila melanogaster: Sema-1b
Drosophila melanogaster: Sema-1a
Mus musculus: Sema6a
Rattus norvegicus: Sema6a

In other databases

CellAge gene expression

This gene is present as SEMA6A

1.

Identifier: rs9894254
Cytogenetic Location: 17q25.3
UCSC Genome Browser: View 17q25.3 on the UCSC genome browser

Gene details

HGNC symbol: SGSH
Aliases: HSS; SFMD; MPS3A
Common name: N-sulfoglucosamine sulfohydrolase
Description: This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
OMIM: 605270
Ensembl: ENSG00000181523
UniProt/Swiss-Prot: SPHM_HUMAN
Entrez Gene: 6448
UniGene: 31074
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: sgsh
Drosophila melanogaster: CG14291
Mus musculus: Sgsh
Rattus norvegicus: Sgsh

In other databases

CellAge gene expression

This gene is present as SGSH

1.

Identifier: rs6997589
Cytogenetic Location: 8p21.3
UCSC Genome Browser: View 8p21.3 on the UCSC genome browser

Gene details

HGNC symbol: SH2D4A
Aliases: SH2A; PPP1R38
Common name: SH2 domain containing 4A
Description
OMIM: 614968
Ensembl: ENSG00000104611
UniProt/Swiss-Prot: SH24A_HUMAN
Entrez Gene: 63898
UniGene: 303208
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: F13B12.6
Danio rerio: sh2d4a
Mus musculus: Sh2d4a
Rattus norvegicus: Sh2d4a

1.

Identifier: rs1429842
Cytogenetic Location: 14q13.3
UCSC Genome Browser: View 14q13.3 on the UCSC genome browser

Gene details

HGNC symbol: SLC25A21
Aliases: ODC; ODC1
Common name: solute carrier family 25 member 21
Description: SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
OMIM: 607571
Ensembl: ENSG00000183032
UniProt/Swiss-Prot: ODC_HUMAN
Entrez Gene: 89874
UniGene: 730857
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: R11.1
Danio rerio: slc25a21
Drosophila melanogaster: CG5254
Drosophila melanogaster: CG9582
Mus musculus: Slc25a21
Rattus norvegicus: Slc25a21
Saccharomyces cerevisiae: ODC2
Saccharomyces cerevisiae: ODC1
Schizosaccharomyces pombe: SPAC328.09

1.

Identifier: rs7656234
Cytogenetic Location: 4q13.3
UCSC Genome Browser: View 4q13.3 on the UCSC genome browser

Gene details

HGNC symbol: SLC4A4
Aliases: KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; kNBC1; SLC4A5; NBCe1-A
Common name: solute carrier family 4 member 4
Description: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
OMIM: 603345
Ensembl: ENSG00000080493
UniProt/Swiss-Prot: A0A024RD97_HUMAN
Entrez Gene: 8671
UniGene: 5462
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: slc4a4a
Danio rerio: slc4a4b
Mus musculus: Slc4a4
Rattus norvegicus: Slc4a4
Saccharomyces cerevisiae: BOR1

1.

Identifier: rs11954180
Cytogenetic Location: 5q32
UCSC Genome Browser: View 5q32 on the UCSC genome browser

Gene details

HGNC symbol: SLC6A7
Aliases: PROT
Common name: solute carrier family 6 member 7
Description: This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]
OMIM: 606205
Ensembl: ENSG00000011083
UniProt/Swiss-Prot: SC6A7_HUMAN
Entrez Gene: 6534
UniGene: 241597
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: SLC6A7
Drosophila melanogaster: CG5549
Mus musculus: Slc6a7
Rattus norvegicus: Slc6a7

1.

Identifier: rs6104550
Cytogenetic Location: 20p12.2
UCSC Genome Browser: View 20p12.2 on the UCSC genome browser

Gene details

HGNC symbol: SNAP25-AS1
Aliases
Common name: SNAP25 antisense RNA 1
Description
OMIM
Ensembl: ENSG00000227906
UniProt/Swiss-Prot
Entrez Gene: 100131208
UniGene: 658178
HapMap: View on HapMap

Homologs in model organisms

No homologs found

1.

Identifier: rs3782415
Cytogenetic Location: 12q22
UCSC Genome Browser: View 12q22 on the UCSC genome browser

Gene details

HGNC symbol: SOCS2
Aliases: CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2
Common name: suppressor of cytokine signaling 2
Description: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
OMIM: 605117
Ensembl: ENSG00000120833
UniProt/Swiss-Prot: A0A024RBD2_HUMAN
Entrez Gene: 8835
UniGene: 485572
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: socs2
Drosophila melanogaster: Socs44A
Mus musculus: Gm9847
Mus musculus: Socs2
Rattus norvegicus: AC124896.1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Socs2

GenAge human genes

This gene is present as SOCS2

CellAge gene expression

This gene is present as SOCS2

1.

Identifier: rs2758331
In Other Studies (IDs): 2168 2644
Cytogenetic Location: 6q25.3
UCSC Genome Browser: View 6q25.3 on the UCSC genome browser

Gene details

HGNC symbol: SOD2
Aliases: IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
Common name: superoxide dismutase 2
Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Other longevity studies of this gene: 21
OMIM: 147460
Ensembl: ENSG00000112096
UniProt/Swiss-Prot: A0A0C4DFU1_HUMAN
Entrez Gene: 6648
UniGene: 487046
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: sod-2
Caenorhabditis elegans: sod-3
Danio rerio: sod2
Drosophila melanogaster: Sod2
Mus musculus: Sod2
Rattus norvegicus: Sod2
Saccharomyces cerevisiae: SOD2
Schizosaccharomyces pombe: SPBC16A3.14

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
A homolog of this gene for Drosophila melanogaster is present as Sod2
A homolog of this gene for Mus musculus is present as Sod2
A homolog of this gene for Caenorhabditis elegans is present as sod-2

GenAge human genes

This gene is present as SOD2

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as SOD2

CellAge

This gene is present as SOD2

1.

Identifier: rs4918255
Cytogenetic Location: 10q25.1
UCSC Genome Browser: View 10q25.1 on the UCSC genome browser

Gene details

HGNC symbol: SORCS1
Aliases: hSorCS
Common name: sortilin related VPS10 domain containing receptor 1
Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 1
OMIM: 606283
Ensembl: ENSG00000108018
UniProt/Swiss-Prot: A8K182_HUMAN
Entrez Gene: 114815
UniGene: 591915
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: SORCS1
Mus musculus: Sorcs1
Rattus norvegicus: Sorcs1
Saccharomyces cerevisiae: VTH1
Saccharomyces cerevisiae: 855803
Saccharomyces cerevisiae: VTH2
Saccharomyces cerevisiae: 855802
Saccharomyces cerevisiae: 850465
Saccharomyces cerevisiae: 850463
Saccharomyces cerevisiae: 850464
Saccharomyces cerevisiae: PEP1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as YNR066C

1.

Identifier: rs6812745
Cytogenetic Location: 4p16.1
UCSC Genome Browser: View 4p16.1 on the UCSC genome browser

Gene details

HGNC symbol: SORCS2
Aliases
Common name: sortilin related VPS10 domain containing receptor 2
Description: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]
OMIM: 606284
Ensembl: ENSG00000184985
UniProt/Swiss-Prot: SORC2_HUMAN
Entrez Gene: 57537
UniGene: 479099
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: sorcs2
Mus musculus: Sorcs2
Rattus norvegicus: Sorcs2
Saccharomyces cerevisiae: 855802
Saccharomyces cerevisiae: 855803
Saccharomyces cerevisiae: VTH1
Saccharomyces cerevisiae: PEP1
Saccharomyces cerevisiae: 850463
Saccharomyces cerevisiae: 850464
Saccharomyces cerevisiae: 850465
Saccharomyces cerevisiae: VTH2

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as YNR066C

1.

Identifier: rs12634249
Cytogenetic Location: 3p26.1
UCSC Genome Browser: View 3p26.1 on the UCSC genome browser

Gene details

HGNC symbol: SUMF1
Aliases: FGE; UNQ3037; AAPA3037
Common name: sulfatase modifying factor 1
Description: This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Other longevity studies of this gene: 2
OMIM: 607939
Ensembl: ENSG00000144455
UniProt/Swiss-Prot: SUMF1_HUMAN
Entrez Gene: 285362
UniGene: 350475
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: sumf1
Drosophila melanogaster: CG7049
Mus musculus: Sumf1
Rattus norvegicus: Sumf1

1.

Identifier: rs9397084
Cytogenetic Location: 6q25.2
UCSC Genome Browser: View 6q25.2 on the UCSC genome browser

Gene details

HGNC symbol: SYNE1
Aliases: 8B; CPG2; ARCA1; EDMD4; KASH1; MYNE1; Nesp1; SCAR8; C6orf98; dJ45H2.2
Common name: spectrin repeat containing nuclear envelope protein 1
Description: This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
OMIM: 608441
Ensembl: ENSG00000131018
UniProt/Swiss-Prot: A0A0C4DG40_HUMAN
Entrez Gene: 23345
UniGene: 12967
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: M116.5
Caenorhabditis elegans: D2096.11
Danio rerio: syne1b
Danio rerio: syne1a
Mus musculus: Syne1

1.

Identifier: rs4755936
Cytogenetic Location: 11p11.2
UCSC Genome Browser: View 11p11.2 on the UCSC genome browser

Gene details

HGNC symbol: SYT13
Aliases
Common name: synaptotagmin 13
Description: This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
OMIM: 607716
Ensembl: ENSG00000019505
UniProt/Swiss-Prot: SYT13_HUMAN
Entrez Gene: 57586
UniGene: 436643
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: snt-4
Danio rerio: syt13
Mus musculus: Syt13
Rattus norvegicus: Syt13

1.

Identifier: rs6443429
Cytogenetic Location: 3q26.32
UCSC Genome Browser: View 3q26.32 on the UCSC genome browser

Gene details

HGNC symbol: TBL1XR1
Aliases: C21; DC42; IRA1; MRD41; TBLR1
Common name: transducin beta like 1 X-linked receptor 1
Description: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
OMIM: 608628
Ensembl: ENSG00000177565
UniProt/Swiss-Prot: TBL1R_HUMAN
Entrez Gene: 79718
UniGene: 714201
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: tbl1xr1b
Danio rerio: tbl1xr1a
Drosophila melanogaster: ebi
Mus musculus: Tbl1xr1
Rattus norvegicus: Tbl1xr1
Saccharomyces cerevisiae: SIF2
Schizosaccharomyces pombe: hif2

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SIF2

1.

Identifier: rs1557967
Cytogenetic Location: 7q34
UCSC Genome Browser: View 7q34 on the UCSC genome browser

Gene details

HGNC symbol: TBXAS1
Aliases: TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14
Common name: thromboxane A synthase 1
Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
OMIM: 274180
Ensembl: ENSG00000059377
UniProt/Swiss-Prot: A0A0A0MSK3_HUMAN
Entrez Gene: 6916
UniGene: 520757
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: cyp-25A4
Caenorhabditis elegans: cyp-13A11
Caenorhabditis elegans: cyp-13A12
Caenorhabditis elegans: cyp-25A6
Caenorhabditis elegans: cyp-25A1
Caenorhabditis elegans: cyp-13B1
Caenorhabditis elegans: cyp-13A10
Caenorhabditis elegans: cyp-25A2
Caenorhabditis elegans: cyp-43A1
Caenorhabditis elegans: cyp-13B2
Caenorhabditis elegans: cyp-13A4
Caenorhabditis elegans: cyp-13A1
Caenorhabditis elegans: cyp-13A7
Caenorhabditis elegans: cyp-25A3
Caenorhabditis elegans: cyp-13A3
Caenorhabditis elegans: cyp-13A2
Caenorhabditis elegans: cyp-13A5
Caenorhabditis elegans: cyp-13A6
Caenorhabditis elegans: cyp-13A8
Danio rerio: tbxas1
Drosophila melanogaster: Cyp6a22
Drosophila melanogaster: Cyp6a17
Drosophila melanogaster: Cyp6a18
Drosophila melanogaster: Cyp9b1
Drosophila melanogaster: Cyp9b2
Drosophila melanogaster: Cyp6a13
Drosophila melanogaster: Cyp6g1
Drosophila melanogaster: Cyp6u1
Drosophila melanogaster: Cyp6a2
Drosophila melanogaster: Cyp6v1
Drosophila melanogaster: Cyp6t1
Drosophila melanogaster: Cyp6w1
Drosophila melanogaster: Cyp6a9
Drosophila melanogaster: Cyp6g2
Drosophila melanogaster: Cyp317a1
Drosophila melanogaster: Cyp9c1
Drosophila melanogaster: Cyp9f2
Drosophila melanogaster: Cyp6t3
Drosophila melanogaster: Cyp6a8
Drosophila melanogaster: Cyp9h1
Drosophila melanogaster: Cyp6a21
Drosophila melanogaster: Cyp6a23
Drosophila melanogaster: Cyp6a19
Mus musculus: Tbxas1
Rattus norvegicus: Tbxas1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as cyp-13B1

GenAge microarray genes

This gene is present as TBXAS1

1.

Identifier: rs563384
Cytogenetic Location: 11q14.1
UCSC Genome Browser: View 11q14.1 on the UCSC genome browser

Gene details

HGNC symbol: TENM4
Aliases: Doc4; ETM5; ODZ4; TNM4; ten-4; Ten-M4
Common name: teneurin transmembrane protein 4
Description: The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
Other longevity studies of this gene: 3
OMIM: 610084
Ensembl: ENSG00000149256
UniProt/Swiss-Prot: TEN4_HUMAN
Entrez Gene: 26011
UniGene: 213087
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: tenm4
Drosophila melanogaster: Ten-m
Mus musculus: Tenm4
Rattus norvegicus: Tenm4

1.

Identifier: rs2116538
Cytogenetic Location: 2q22.1
UCSC Genome Browser: View 2q22.1 on the UCSC genome browser

Gene details

HGNC symbol: THSD7B
Aliases
Common name: thrombospondin type 1 domain containing 7B
Description
OMIM
Ensembl: ENSG00000144229
UniProt/Swiss-Prot: E7EM75_HUMAN
Entrez Gene: 80731
UniGene: 68533
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: spon-1
Drosophila melanogaster: CG30203
Drosophila melanogaster: CG30046
Drosophila melanogaster: CG17739
Drosophila melanogaster: fat-spondin
Mus musculus: Thsd7b
Rattus norvegicus: Thsd7b

1.

Identifier: rs524533
Cytogenetic Location: 6p21.1
UCSC Genome Browser: View 6p21.1 on the UCSC genome browser

Gene details

HGNC symbol: TMEM151B
Aliases: TMEM193; C6orf137; bA444E17.5
Common name: transmembrane protein 151B
Description
OMIM
Ensembl: ENSG00000178233
UniProt/Swiss-Prot: T151B_HUMAN
Entrez Gene: 441151
UniGene: 632851
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ZK1067.4
Danio rerio: tmem151bb
Danio rerio: tmem151ba

1.

Identifier: rs12341685
Cytogenetic Location: 9q21.13
UCSC Genome Browser: View 9q21.13 on the UCSC genome browser

Gene details

HGNC symbol: TMEM2
Aliases
Common name: transmembrane protein 2
Description: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]
OMIM: 605835
Ensembl: ENSG00000135048
UniProt/Swiss-Prot: A0A024R229_HUMAN
Entrez Gene: 23670
UniGene: 494146
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: tmem2
Mus musculus: Tmem2
Rattus norvegicus: Tmem2

1.

Identifier: rs8083511
Cytogenetic Location: 18q21.33
UCSC Genome Browser: View 18q21.33 on the UCSC genome browser

Gene details

HGNC symbol: TNFRSF11A
Aliases: FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
Common name: TNF receptor superfamily member 11a
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
OMIM: 603499
Ensembl: ENSG00000141655
UniProt/Swiss-Prot: TNR11_HUMAN
Entrez Gene: 8792
UniGene: 204044
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: tnfrsf11a
Mus musculus: Tnfrsf11a
Rattus norvegicus: Tnfrsf11a

1.

Identifier: rs3181360
Cytogenetic Location: 9q32-q33.1
UCSC Genome Browser: View 9q32-q33.1 on the UCSC genome browser

Gene details

HGNC symbol: TNFSF8
Aliases: CD153; CD30L; CD30LG; TNLG3A
Common name: TNF superfamily member 8
Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
OMIM: 603875
Ensembl: ENSG00000106952
UniProt/Swiss-Prot: A0A087X228_HUMAN
Entrez Gene: 944
UniGene: 494901
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Tnfsf8
Rattus norvegicus: Tnfsf8

1.

Identifier: rs2075650
In Other Studies (IDs): 282 355 360 723 899
Cytogenetic Location: 19q13.32
UCSC Genome Browser: View 19q13.32 on the UCSC genome browser

Gene details

HGNC symbol: TOMM40
Aliases: TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E
Common name: translocase of outer mitochondrial membrane 40
Description: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Other longevity studies of this gene: 6
OMIM: 608061
Ensembl: ENSG00000130204
UniProt/Swiss-Prot: TOM40_HUMAN
Entrez Gene: 10452
UniGene: 655909
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: tomm-40
Danio rerio: tomm40l
Danio rerio: tomm40
Drosophila melanogaster: Tom40
Drosophila melanogaster: tomboy40
Mus musculus: Tomm40
Rattus norvegicus: Tomm40
Saccharomyces cerevisiae: TOM40

In other databases

CellAge gene expression

This gene is present as TOMM40

1.

Identifier: rs10957071
Cytogenetic Location: 8q12.1
UCSC Genome Browser: View 8q12.1 on the UCSC genome browser

Gene details

HGNC symbol: TOX
Aliases: TOX1
Common name: thymocyte selection associated high mobility group box
Description: The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]
OMIM: 606863
Ensembl: ENSG00000198846
UniProt/Swiss-Prot: TOX_HUMAN
Entrez Gene: 9760
UniGene: 491805
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: hmg-6
Danio rerio: tox
Drosophila melanogaster: CG12104
Mus musculus: Tox
Rattus norvegicus: Tox
Saccharomyces cerevisiae: POB3

1.

Identifier: rs205499
Cytogenetic Location: 17q22
UCSC Genome Browser: View 17q22 on the UCSC genome browser

Gene details

HGNC symbol: TRIM25
Aliases: EFP; Z147; RNF147; ZNF147
Common name: tripartite motif containing 25
Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
OMIM: 600453
Ensembl: ENSG00000121060
UniProt/Swiss-Prot: TRI25_HUMAN
Entrez Gene: 7706
UniGene: 528952
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: trim25
Mus musculus: Trim25
Rattus norvegicus: Trim25

1.

Identifier: rs3769583
Cytogenetic Location: 2p22.3
UCSC Genome Browser: View 2p22.3 on the UCSC genome browser

Gene details

HGNC symbol: TTC27
Aliases
Common name: tetratricopeptide repeat domain 27
Description
OMIM
Ensembl: ENSG00000018699
UniProt/Swiss-Prot: B4DRC7_HUMAN
Entrez Gene: 55622
UniGene: 468125
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: trd-1
Danio rerio: ttc27
Drosophila melanogaster: CG5290
Mus musculus: Ttc27
Rattus norvegicus: Ttc27
Saccharomyces cerevisiae: EMW1
Schizosaccharomyces pombe: SPAC19B12.01

1.

Identifier: rs10483493
Cytogenetic Location: 14q21.1
UCSC Genome Browser: View 14q21.1 on the UCSC genome browser

Gene details

HGNC symbol: TTC6
Aliases: C14orf25; NCRNA00291
Common name: tetratricopeptide repeat domain 6
Description
OMIM
Ensembl: ENSG00000139865
UniProt/Swiss-Prot
Entrez Gene: 319089
UniGene: 659936
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: ttc6

1.

Identifier: rs882696
Cytogenetic Location: 8p22
UCSC Genome Browser: View 8p22 on the UCSC genome browser

Gene details

HGNC symbol: TUSC3
Aliases: M33; N33; MRT7; MRT22; OST3A; D8S1992
Common name: tumor suppressor candidate 3
Description: This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
OMIM: 601385
Ensembl: ENSG00000104723
UniProt/Swiss-Prot: TUSC3_HUMAN
Entrez Gene: 7991
UniGene: 426324
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ZK686.3
Danio rerio: tusc3
Drosophila melanogaster: Ostgamma
Mus musculus: Tusc3
Rattus norvegicus: Tusc3
Saccharomyces cerevisiae: OST3

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as OST3

1.

Identifier: rs3817530
Cytogenetic Location: 7q32.2
UCSC Genome Browser: View 7q32.2 on the UCSC genome browser

Gene details

HGNC symbol: UBE2H
Aliases: GID3; UBC8; UBCH; UBCH2; E2-20K
Common name: ubiquitin conjugating enzyme E2 H
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
OMIM: 601082
Ensembl: ENSG00000186591
UniProt/Swiss-Prot: A4D1L5_HUMAN
Entrez Gene: 7328
UniGene: 643548
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ubc-8
Danio rerio: ube2h
Drosophila melanogaster: UbcE2H
Mus musculus: Ube2h
Rattus norvegicus: Ube2h
Saccharomyces cerevisiae: UBC8
Schizosaccharomyces pombe: ubc8

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as UBC8

CellAge gene expression

This gene is present as UBE2H

1.

Identifier: rs10518725
Cytogenetic Location: 15q21.3
UCSC Genome Browser: View 15q21.3 on the UCSC genome browser

Gene details

HGNC symbol: WDR72
Aliases: AI2A3
Common name: WD repeat domain 72
Description: This gene encodes a protein with eight WD-40 repeats. Mutations in this gene have been associated with amelogenesis imperfecta hypomaturation type 2A3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
OMIM: 613214
Ensembl: ENSG00000166415
UniProt/Swiss-Prot: A0A087WTC3_HUMAN
Entrez Gene: 256764
UniGene: 122125
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: rbc-2
Drosophila melanogaster: Rbcn-3B
Mus musculus: Wdr72
Rattus norvegicus: Wdr72

1.

Identifier: rs1800392
Cytogenetic Location: 8p12
UCSC Genome Browser: View 8p12 on the UCSC genome browser

2.

Identifier: rs3024239
Cytogenetic Location: 8p12
UCSC Genome Browser: View 8p12 on the UCSC genome browser

Gene details

HGNC symbol: WRN
Aliases: RECQ3; RECQL2; RECQL3
Common name: Werner syndrome RecQ like helicase
Description: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 25
OMIM: 604611
Ensembl: ENSG00000165392
UniProt/Swiss-Prot: Q59F09_HUMAN
Entrez Gene: 7486
UniGene: 632050
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: wrn-1
Danio rerio: wrn
Mus musculus: Wrn
Rattus norvegicus: Wrn
Saccharomyces cerevisiae: SGS1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SGS1

GenAge human genes

This gene is present as WRN

CellAge

This gene is present as WRN

1.

Identifier: rs2738679
Cytogenetic Location: 16q23.1-q23.2
UCSC Genome Browser: View 16q23.1-q23.2 on the UCSC genome browser

Gene details

HGNC symbol: WWOX
Aliases: FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
Common name: WW domain containing oxidoreductase
Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
OMIM: 605131
Ensembl: ENSG00000186153
UniProt/Swiss-Prot: WWOX_HUMAN
Entrez Gene: 51741
UniGene: 461453
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: wwox
Drosophila melanogaster: Wwox
Mus musculus: Wwox
Saccharomyces cerevisiae: ENV9

1.

Identifier: rs4952085
Cytogenetic Location: 2p23.1
UCSC Genome Browser: View 2p23.1 on the UCSC genome browser

Gene details

HGNC symbol: XDH
Aliases: XO; XOR; XAN1
Common name: xanthine dehydrogenase
Description: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
Other longevity studies of this gene: 23
OMIM: 607633
Ensembl: ENSG00000158125
UniProt/Swiss-Prot: XDH_HUMAN
Entrez Gene: 7498
UniGene: 250
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: F55B11.1
Caenorhabditis elegans: gad-3
Caenorhabditis elegans: F15E6.6
Danio rerio: xdh
Drosophila melanogaster: AOX4
Drosophila melanogaster: ry
Drosophila melanogaster: AOX1
Drosophila melanogaster: AOX2
Drosophila melanogaster: AOX3
Mus musculus: Xdh
Rattus norvegicus: Xdh

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as F55B11.1
A homolog of this gene for Drosophila melanogaster is present as ry

1.

Identifier: rs4240673
Cytogenetic Location: 8p23.1
UCSC Genome Browser: View 8p23.1 on the UCSC genome browser

2.

Identifier: rs6984496
Cytogenetic Location: 8p23.1
UCSC Genome Browser: View 8p23.1 on the UCSC genome browser

3.

Identifier: rs11783247
Cytogenetic Location: 8p23.1
UCSC Genome Browser: View 8p23.1 on the UCSC genome browser

Gene details

HGNC symbol: XKR6
Aliases: XRG6; C8orf5; C8orf7; C8orf21
Common name: XK related 6
Description
Other longevity studies of this gene: 2
OMIM
Ensembl: ENSG00000171044
UniProt/Swiss-Prot: Q96KT3_HUMAN
Entrez Gene: 286046
UniGene: 657083
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: ced-8
Danio rerio: xkr6b
Danio rerio: xkr6a
Drosophila melanogaster: CG32579
Mus musculus: Xkr6
Rattus norvegicus: Xkr6

1.

Identifier: rs10511330
Cytogenetic Location: 3q13.31
UCSC Genome Browser: View 3q13.31 on the UCSC genome browser

Gene details

HGNC symbol: ZBTB20
Aliases: HOF; DPZF; PRIMS; ODA-8S; ZNF288
Common name: zinc finger and BTB domain containing 20
Description: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
OMIM: 606025
Ensembl: ENSG00000181722
UniProt/Swiss-Prot: B2RCW4_HUMAN
Entrez Gene: 26137
UniGene: 202577
HapMap: View on HapMap

Homologs in model organisms

Danio rerio: zbtb20
Mus musculus: Zbtb20
Rattus norvegicus: Zbtb20

In other databases

CellAge gene expression

This gene is present as ZBTB20

1.

Identifier: rs11005328
Cytogenetic Location: 10q21.1
UCSC Genome Browser: View 10q21.1 on the UCSC genome browser

Gene details

HGNC symbol: ZWINT
Aliases: SIP30; ZWINT1; KNTC2AP; HZwint-1
Common name: ZW10 interacting kinetochore protein
Description: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OMIM: 609177
Ensembl: ENSG00000122952
UniProt/Swiss-Prot: ZWINT_HUMAN
Entrez Gene: 11130
UniGene: 591363
HapMap: View on HapMap

Homologs in model organisms

Mus musculus: Zwint
Rattus norvegicus: Zwint

In other databases

CellAge gene expression

This gene is present as ZWINT

LongevityMap variant group

Entry Details

Variants (281)

No gene

ADAMTSL1

Gene details

Homologs in model organisms

AIF1

Gene details

Homologs in model organisms

In other databases

ANGEL1

Gene details

Homologs in model organisms

APBB2

Gene details

Homologs in model organisms

ASIC2

Gene details

Homologs in model organisms

ATXN7L3B

Gene details

Homologs in model organisms

BABAM2

Gene details

Homologs in model organisms

BHLHE41

Gene details

Homologs in model organisms

BTBD19

Gene details

Homologs in model organisms

BTG3

Gene details

Homologs in model organisms

In other databases

BTNL2

Gene details

Homologs in model organisms

C2

Gene details

Homologs in model organisms

In other databases

C20orf194

Gene details

Homologs in model organisms

C20orf78

Gene details

Homologs in model organisms

C9orf3

Gene details

Homologs in model organisms

CADM1

Gene details

Homologs in model organisms

CAMTA1

Gene details

Homologs in model organisms

CCDC85A

Gene details

Homologs in model organisms

CCDC88C

Gene details

Homologs in model organisms

CDK14

Gene details

Homologs in model organisms

In other databases

CDK6

Gene details

Homologs in model organisms

In other databases

CDKN2B

Gene details

Homologs in model organisms

In other databases

CDKN2B-AS1

Gene details

Homologs in model organisms

CGNL1