LongevityMap Gene

Gene details

HGNC symbol: G6PD
Aliases: G6PD1
Common name: glucose-6-phosphate dehydrogenase
Description: This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Cytogenetic Location: Xq28
UCSC Genome Browser: View Xq28 on the UCSC genome browser
OMIM: 305900
Ensembl: ENSG00000160211
UniProt/Swiss-Prot: G6PD_HUMAN
Entrez Gene: 2539
UniGene: 461047
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: gspd-1
Danio rerio: g6pd
Drosophila melanogaster: Zw
Mus musculus: G6pdx
Mus musculus: G6pd2
Rattus norvegicus: G6pd
Saccharomyces cerevisiae: ZWF1
Schizosaccharomyces pombe: zwf1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Zw
A homolog of this gene for Saccharomyces cerevisiae is present as ZWF1
A homolog of this gene for Mus musculus is present as G6PD

GenAge microarray genes

This gene is present as G6PD

GenDR gene expression

A homolog of this gene for Mus musculus is present as G6pdx

CellAge

This gene is present as G6PD

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Danish

Study Design

38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.

Conclusions

No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.

Indentifier

rs2472393

Reference