Cell Senescence Entries for G6PD
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Ho et al. (2000) Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 29(2)156-69 (PubMed)
G6PD Gene Information
- HGNC symbol
- G6PD
- Aliases
- G6PD1
- Common name
- glucose-6-phosphate dehydrogenase
- Entrez Id
- 2539
- Description
- This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
G6PD Ontologies
- Gene Ontology
-
Process: GO:6006; glucose metabolic process
GO:5975; carbohydrate metabolic process
GO:19637; organophosphate metabolic process
GO:6098; pentose-phosphate shunt
GO:6739; NADP metabolic process
GO:21762; substantia nigra development
GO:6629; lipid metabolic process
GO:9051; pentose-phosphate shunt, oxidative branch
GO:51156; glucose 6-phosphate metabolic process
GO:6749; glutathione metabolic process
GO:6695; cholesterol biosynthetic process
And 15 more GO terms Cellular component: GO:5829; cytosol
GO:34451; centriolar satellite
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:70062; extracellular exosome
GO:9898; cytoplasmic side of plasma membrane
GO:5634; nucleus
Function: GO:16614; oxidoreductase activity, acting on CH-OH group of donors
GO:50661; NADP binding
GO:4345; glucose-6-phosphate dehydrogenase activity
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5536; glucose binding
GO:30246; carbohydrate binding
Homologs of G6PD in Model Organisms
- Caenorhabditis elegans
- gspd-1
- Danio rerio
- g6pd
- Drosophila melanogaster
- Zw
- Mus musculus
- G6pdx
- Mus musculus
- G6pd2
- Rattus norvegicus
- G6pd
- Saccharomyces cerevisiae
- ZWF1
- Schizosaccharomyces pombe
- zwf1
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as G6PD
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as G6pdx
- LongevityMap
- This gene is present as G6PD
External links
- OMIM
- 305900
- Ensembl
- ENSG00000160211
- Entrez Gene
- 2539
- UniGene
- 684904
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- G6PD
- GeneCards
- G6PD