LongevityMap Gene
Gene details
- HGNC symbol
- CYP1A1
- Aliases
- AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
- Common name
- cytochrome P450 family 1 subfamily A member 1
- Description
- This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
- Cytogenetic Location
- 15q24.1
- UCSC Genome Browser
- View 15q24.1 on the UCSC genome browser
- OMIM
- 108330
- Ensembl
- ENSG00000140465
- UniProt/Swiss-Prot
- A0N0X8_HUMAN
- Entrez Gene
- 1543
- UniGene
- 72912
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- Italian (Northern)
- Study Design
- Polymorphisms were examined in 94 nonagenarians and centenarians and 418 control subjects of younger age
- Conclusions
- No association with longevity was found
- Indentifier
- CYP1A1
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- T461N and 3801 T/ C SNPs were examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years
- Conclusions
- No association with longevity was found
- Indentifier
- T461N
- Reference