LongevityMap Gene

Gene details

HGNC symbol: CTNNA3
Aliases: VR22; ARVD13
Common name: catenin alpha 3
Description: This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Cytogenetic Location: 10q21.3
UCSC Genome Browser: View 10q21.3 on the UCSC genome browser
OMIM: 607667
Ensembl: ENSG00000183230
UniProt/Swiss-Prot: A8K141_HUMAN
Entrez Gene: 29119
UniGene: 21375
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/1

Longevity Association: Non-significant
Population: German
Study Design: Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions: Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
Indentifier

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions: 281 SNPs were found to discriminate between cases and controls
Indentifier