LongevityMap Gene
Gene details
- HGNC symbol
- CLU
- Aliases
- CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
- Common name
- clusterin
- Description
- The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
- Cytogenetic Location
- 8p21.1
- UCSC Genome Browser
- View 8p21.1 on the UCSC genome browser
- OMIM
- 185430
- Ensembl
- ENSG00000120885
- UniProt/Swiss-Prot
- CLUS_HUMAN
- Entrez Gene
- 1191
- UniGene
- 436657
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Apart APOE, no variants appeared to be associated with aging with a genome-wide level of significance
- Indentifier
- rs11136000
- Reference