Cell Senescence Entries for CLU
- Cell Types
- Cervical cancer
- Cell Lines
- L-02
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2019) Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. Ecotoxicol Environ Saf 183(2)109465 (PubMed)
CLU Gene Information
- HGNC symbol
- CLU
- Aliases
- APOJ; CLI; CLU1; CLU2; KUB1; SGP-2; SP-40; TRPM-2
- Common name
- clusterin
- Entrez Id
- 1191
- Description
- The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011].
CLU Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:2376; immune system process
GO:45087; innate immune response
GO:43065; positive regulation of apoptotic process
GO:42127; regulation of cell population proliferation
GO:6958; complement activation, classical pathway
GO:50821; protein stabilization
GO:42981; regulation of apoptotic process
GO:9615; response to virus
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:10628; positive regulation of gene expression
And 38 more GO terms Cellular component: GO:5615; extracellular space
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
And 18 more GO terms Function: GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
GO:51082; unfolded protein binding
GO:1540; amyloid-beta binding
GO:5102; signaling receptor binding
GO:50750; low-density lipoprotein particle receptor binding
GO:48156; tau protein binding
GO:51087; chaperone binding
GO:44877; protein-containing complex binding
GO:140597; protein carrier activity
GO:51787; misfolded protein binding
And 1 more GO terms
Homologs of CLU in Model Organisms
In other databases
External links
- OMIM
- 185430
- Ensembl
- ENSG00000120885
- Entrez Gene
- 1191
- UniGene
- 436657
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CLU
- GeneCards
- CLU